Beilstein J. Org. Chem.2023,19, 687–699, doi:10.3762/bjoc.19.50
of two ring bonds. This review includes the recent syntheses of seven to fourteen-membered phostam, phostone, and phostine derivatives.
Keywords: azaphosphaheterocycle; oxaphosphaheterocycle; phostam; phostine; phostone; Introduction
Phostams, phostones, and phostines are a class of important
phostine derivatives, less attention has been paid to the synthesis of medium and large phostam, phostone, and phostine derivatives. They are also biologically active compounds, such as inhibitors of the human farnesyl pyrophosphate synthase [21][22], antitumor agents [23], and hapten for the production of
the catalytic antibody [24]. They are also potential chiral ligands in asymmetric catalysis [25] (Figure 1).
Cyclizations and annulations are two major strategies for the synthesis of medium and large phostam, phostone, and phostine derivatives. The cyclizations have been applied in the construction
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Graphical Abstract
Figure 1:
Biologically active agents and chiral ligands containing medium and large phostams, phostones, and ...