Synthesis of diaryl phosphates using phytic acid as a phosphorus source

• Kazuya Asao,
• Seika Matsumoto,
• Haruka Mori,
• Riku Yoshimura,
• Takeshi Sasaki,
• Naoya Hirata,
• Yasuyuki Hayakawa and
• Shin-ichi Kawaguchi

Beilstein J. Org. Chem. 2026, 22, 213–223, doi:10.3762/bjoc.22.15

• Research, Saga University, 152-1 Shonan-cho, Karatsu, Saga 847-0021, Japan Nippon Concrete Industries Co., Ltd., 4-6-14 Shibaura, Minato-ku, Tokyo 108-8560, Japan 10.3762/bjoc.22.15 Abstract Phytic acid is a phosphorus-rich molecule, which is produced by plants using water-soluble phosphates absorbed from

• soil. It can potentially serve as a phosphorus source in the syntheses of organic phosphates; however, this approach has not been utilized for the preparation of phosphate esters. In this study, we report the first successful synthesis of phosphate esters using phytic acid as a phosphorus source. Crude

• products of phosphate diesters were obtained through the reactions of commercially available phytic acid and aromatic alcohols with 31P nuclear magnetic resonance yields up to 83%. We also isolated a portion of the reaction substrates with yields up to 60%. Next, we extracted phytic acid from rice bran