Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation

• Wei Jie Li,
• Zun Le Xu and
• Sheng Xiang Qiu

Beilstein J. Org. Chem. 2010, 6, No. 29, doi:10.3762/bjoc.6.29

• , Sun Yat-Sen University, 135 Xingang West Road, Haizhou District, Guangzhou 510275, China 10.3762/bjoc.6.29 Abstract Seven polyoxazoline ligands were synthesized in high yield in a one-pot reaction by heating polycarboxylic acids or their esters and chiral β-amino alcohols under reflux with

• the linkers and the substituents present on the oxazoline rings on the yield and enantioselectivity investigated. Compound 2 was identified as the best ligand of this family for the hydrosilylation of aromatic ketones. Keywords: aromatic ketone; hydrosilylation; polyoxazoline; rhodium; synthesis

• prepare enantiomerically pure compounds; in particular, a range of mono- and bisoxazolines have been widely used as effective templates for metal-catalyzed asymmetric reactions over the last 30 years [1][2][3][4][5][6][7][8][9][10][11][12][13]. Previously, polyoxazoline ligands were reported to have good