Release of β-galactosidase from poloxamine/α-cyclodextrin hydrogels

• César A. Estévez,
• José Ramón Isasi,
• Eneko Larrañeta and
• Itziar Vélaz

Beilstein J. Org. Chem. 2014, 10, 3127–3135, doi:10.3762/bjoc.10.330

• : controlled release; cyclodextrins; lactase; polypseudorotaxane; supramolecular gel; Introduction In the Western diet, carbohydrates contribute about 50% of calories, distributed in the following ratio: starch (50%), sucrose (30%), lactose (6%), maltose (1–2%), and others (12%: trehalose, glucose, fructose

• , which can be used as supramolecular drug delivery systems [11]. Thus, cyclodextrin-based physical hydrogels assembled through microcrystalline formation are based upon the aggregation of polypseudorotaxane structures [12]. In the case of reverse Tetronics, α-cyclodextrin (composed of six glucose units

• ) forms a polypseudorotaxane structure in water with the inner PEO units of these copolymers, as can be seen in Figure 1. We have recently shown that these structures form self-assembled gels under certain conditions [13]. These gels can be designed to encapsulate and then continuously release the lactase

Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier

• Kayoko Hayashida,
• Taishi Higashi,
• Daichi Kono,
• Keiichi Motoyama,
• Koki Wada and
• Hidetoshi Arima

Beilstein J. Org. Chem. 2014, 10, 2756–2764, doi:10.3762/bjoc.10.292

• products. Keywords: cyclodextrins; doxorubicin; PEGylated liposome; polypseudorotaxane; sustained release; Introduction Cyclodextrins (CDs) are cyclic oligosaccharides comprising six (α-CD), seven (β-CD), and eight (γ-CD) glucopyranose units. They are characterized by a hydrophobic central cavity and a

Loose-fit polypseudorotaxanes constructed from γ-CDs and PHEMA-PPG-PEG-PPG-PHEMA

• Tao Kong,
• Lin Ye,
• Ai-ying Zhang and
• Zeng-guo Feng

Beilstein J. Org. Chem. 2014, 10, 2461–2469, doi:10.3762/bjoc.10.257

• -hydroxyethyl methacrylate); polypseudorotaxane; Introduction Cyclodextrins (CDs) are a family of cyclic oligosaccharides composed of 6, 7 or 8 glucose units linked via α-1,4-glycosidic bonds. Due to the presence of a hydrophobic inner cavity with different geometric dimensions, CDs can act as host molecules