Pyridinoacridine alkaloids of marine origin: NMR and MS spectral data, synthesis, biosynthesis and biological activity

• Louis P. Sandjo,
• Victor Kuete and
• Maique W. Biavatti

Beilstein J. Org. Chem. 2015, 11, 1667–1699, doi:10.3762/bjoc.11.183

• are also discussed. Pyridoacridines were found to have a large spectrum of bioactivity and this review highlights and compares the pharmacophores that are responsible for the observed bioactivity. Keywords: biosynthesis; 13C NMR shifts; pharmacophores; pyridoacridines; synthesis; Introduction In

• atoms. Fortunately, NMR techniques such as 1,n-ADEQUATE can be used to solve the problem of carbon assignment but the experimental time is long, the sensitivity is poor, and a substantial amount of sample is required. However, pyridoacridines present some structural features that can be used for

• composition leading to the deduction of the structure. Mass fragmentation The mass spectrometry spectrum of pyridoacridines contains very little information due to the lack of fragments. Independent of the ionization source used to determine the elemental composition (ESI, DIC, APCI, FAB, or EI), molecules