Beilstein J. Org. Chem.2015,11, 897–905, doi:10.3762/bjoc.11.101
hemiacetals after cascade reactions.
Keywords: alkyne cyclization; gold-catalyzed reaction; indolo-oxazin-1-one; marine natural products; pyrrolo-oxazin-1-one; Introduction
Pyrrole-containing heterocycles are widely distributed within a large number of natural products and biologically active molecules [1
structure 6 or 7 was not formed.
After failure of the cyclization reaction of 13 with AuCl3, even in water-free solvents, we turned our attention to the construction of the pyrrolo-oxazin-1-one skeleton with the corresponding acid 15. For this purpose, the propargyl ester 13 was first hydrolyzed with K2CO3
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Graphical Abstract
Figure 1:
Structures of some marine natural products 1–4.