Beilstein J. Org. Chem.2020,16, 1596–1605, doi:10.3762/bjoc.16.132
(Chromodorididae, Doridoidea) nudibranchs, their egg ribbons, and the associated dietary sponge Spongia cf. agaricina (Demospongiae, Porifera) led to the isolation of the structurally new scalarane-type sesterterpene 12-deacetoxy-4-demethyl-11,24-diacetoxy-3,4-methylenedeoxoscalarin, with an unprecedented position
the genus Doriprismatica and scalarane-containing dictyoceratid sponges of the Spongiidae family. The results also indicate that D. stellata passes the scalarane metabolite on to its egg ribbons, most likely for protective purposes. The scalarane showed antibacterial activity against the Gram-positive
bacteria Arthrobacter crystallopoietes (DSM 20117) and Bacillus megaterium (DSM 32).
Keywords: antibacterial; Dictyoceratida; Nudibranchia; scalarane; sesterterpene; Introduction
In habitats with intense competition and feeding pressure, such as coral reefs, sessile or slow-moving organisms commonly