Synthesis of odorants in flow and their applications in perfumery

• Merlin Kleoff,
• Paul Kiler and
• Philipp Heretsch

Beilstein J. Org. Chem. 2022, 18, 754–768, doi:10.3762/bjoc.18.76

• the main odor families “fruity”, “green”, “marine”, “floral”, “spicy”, “woody”, “ambery”, and “musky” and their use and importance for perfumery is briefly discussed. Keywords: flow chemistry; fragrances; odorants; scents; terpenes; Introduction The history of odorants goes back to ancient cultures

• perfumes and cosmetics is strongly driven by the development of new odorants with unprecedented scents or superior physical properties [3][4][5][6][7][8]. Ernest Beaux, creator of Chanel No. 5, even claimed that “the future of perfumery is in the hand of chemistry” [3]. In addition, the industrial

• are many different types of scents, there are various classifications for fragrances. In this review, fragrances are ordered from “fruity” to “musky” following the olfactory spectrum wheel developed by Kraft and co-workers (Figure 1) [3][4]. It has to be noted that this is only a simple and subjective

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

• Guido Gambacorta,
• James S. Sharley and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90

• syntheses [3][4][5][6][7]. Fragrance chemistry Since the earliest documented use of fragrances in ancient Egypt and Mesopotamia to current times, the human race has always been fascinated by the manipulation and enhancement of scents. Although nature supplies an abundance of inspiration, the fragrance

• perfumer, it has been shown to be highly consistent with other studies and approaches from across the scientific literature [13]. Each principle note can be further subdivided yielding a related family of scents. For example, the oriental family represent odours that would be associated with amber, incense

• , vanilla and those possessing spicy and resinous characteristics (i.e., 1–3). Woody notes are often associated with scents such as cedar, patchouli, pine, sandalwood and vetiver, it also includes the more mossy fragrances, for example, oakmoss (i.e., 4–7). Fresh notes are often associated with ozonic or

Synthetic terpenoids in the world of fragrances: Iso E Super^® is the showcase

• Alexey Stepanyuk and
• Andreas Kirschning

Beilstein J. Org. Chem. 2019, 15, 2590–2602, doi:10.3762/bjoc.15.252

• portfolio of new scents increased either in order to substitute natural fragrances without change of olfactoric properties or to broaden the scope of scents. This short review describes the story of the most successful synthetic fragrance ever which is called Iso E Super® as it is an ingredient in a large

• : asymmetric synthesis; fragrances; odorants; sandalwood; scents; terpenes; terpenoids; Review “Iso E Super® is to perfume what Tango Nuevo is to Tango Argentino” [1] Introduction – classical terpenes in perfumes Perfumes (Latin “per fumus”, which means “through smoke”) have accompanied mankind for thousands

• ) from which the acetate (26) can be prepared by semisynthesis [6]. Obviously, nature served as starting point and guideline for creating scents and these lists reveal, that terpenes, particularly mono- and sesquiterpenes, have played a rather dominant role in the fragrance industries [6]. Over the last