Beilstein J. Org. Chem.2011,7, 29–33, doi:10.3762/bjoc.7.5
I. V. Sunil Kumar G. S. R. Anjaneyulu V. Hima Bindu Research and Development Centre, Aptuit Laurus Private Limited, ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad-500078, India Institute of Science and Technology, JNTU, Hyderabad-500072, India 10.3762/bjoc.7.5 Abstract Sertindole (1), an
fragmentation patterns in LC-MS. Most of the impurities were synthesized and their assigned constitutions confirmed by co-injection in HPLC. We describe herein the formation, synthesis and characterization of these impurities. Our study will be of immense help to others to obtain chemically pure sertindole
.
Keywords: impurity profile; related substances; sertindole; Introduction
The safety of a drug product is not only dependent on the toxicological properties of the active drug substance (or API), but also on the impurities formed during the various chemical transformations. Therefore, identification
PDF
Graphical Abstract
Figure 1:
Sertindole (1), process related impurities and metabolites.