Sordarin, an antifungal agent with a unique mode of action

• Huan Liang

Beilstein J. Org. Chem. 2008, 4, No. 31, doi:10.3762/bjoc.4.31

• total syntheses (by the Kato, Mander and Narasaka groups), modifications of the glycosyl unit, and changes to the diterpene core (Cuevas and Ciufolini models) will also be discussed in this review. Keywords: antifungal; bioactivity; sordaricin; sordarin; total synthesis; Introduction For

• Switzerland, and it was patented as SL 2266 [3][4]. The degradation of sordarin with concentrated aqueous HCl in acetone released a diterpenoid aglycone called sordaricin (2) (Figure 2). Sordarin production by fermentation was optimized to simplify purification [5] and to increase the yield [6]. Interestingly

• and its congeners have been published. The first syntheses of sordaricin methyl ester and its Δ2-derivative were achieved by Kato in 1993 [13]. Then the Mander group completed sordaricin in 2003 [14][15] and the Narasaka group reported total syntheses of racemic sordaricin [16] and enantiopure