Beilstein J. Org. Chem.2008,4, No. 39, doi:10.3762/bjoc.4.39
γ-carboxy group of aspartic acid, led to a cyclic intermediate. Appending N-acetylnorleucine concluded the assembly of melanotan II molecule. Protection of the lateral groups in arginine and tryptophan was omitted for atom and stepeconomy reasons. The total synthesis of melanotan II was