Research progress on calixarene/pillararene-based controlled drug release systems

• Liu-Huan Yi,
• Jian Qin,
• Si-Ran Lu,
• Liu-Pan Yang,
• Li-Li Wang and
• Huan Yao

Beilstein J. Org. Chem. 2025, 21, 1757–1785, doi:10.3762/bjoc.21.139

• of controlled-release technologies, with the aim of offering a reference for the utilization of aromatic macrocycles in drug-controlled release applications. Keywords: aromatic macrocycle; controlled-release drug delivery systems; stimulus response; supramolecular chemistry; Introduction Drugs are

• discussed the controlled drug release of single-stimulus-responsive systems, adopting a relatively simple perspective of a single stimulus-response. Multistimuli responsiveness also holds potential applications in terms of responsiveness and efficient drug release. One of the major challenges faced by

• responses have a broad application prospect in controlling drug release. For example, supramolecular peptide assemblies that naturally respond to pH or ion strength can be designed to include light-responsive elements or feature-specific enzyme substrates, thus utilizing two separate stimulus-response