Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

• Franziska Hemmerling and
• Frank Hahn

Beilstein J. Org. Chem. 2016, 12, 1512–1550, doi:10.3762/bjoc.12.148

Natural products from microbes associated with insects

• Christine Beemelmanns,
• Huijuan Guo,
• Maja Rischer and
• Michael Poulsen

Beilstein J. Org. Chem. 2016, 12, 314–327, doi:10.3762/bjoc.12.34

• conjugated heptaene moiety [86][87]. Subsequent chemical analysis of another Streptomyces strain associated with the southern pine beetle led to the discovery of two new members of polyketide-derived polycyclic tetramate macrolactams named frontalamides A (13) and B (14) (Figure 5) [88][89], which also

Synthesis and antibacterial activity of monocyclic 3-carboxamide tetramic acids

• Yong-Chul Jeong and
• Mark G. Moloney

Beilstein J. Org. Chem. 2013, 9, 1899–1906, doi:10.3762/bjoc.9.224

• rapid construction, and the evaluation of their antibacterial activity is reported. Keywords: acylation; antibacterial; drug discovery; natural products; tetramate; Introduction The discovery of new antibiotic families with novel modes of action is a promising way to overcome resistant or virulent

• cyclisation of N-acetoacetylamino acid esters leading to 3-acetyltetramates has been reported, which give N–H rather than N-alkyl systems [15][16][17]. Tetramate 7 was obtained from amino acid 6, except that the key intermediate 5 was obtained by reductive amination (Scheme 2) of (R)-citronellal (4), which

• generality [20][21]. We found that an approach based upon direct acylation of methyl thioethers 8a,b (these were readily obtained from the required N-acylmethionine by DCC/DMAP coupling with Meldrum’s acid and cyclisation under reflux) was possible, which made use of the high acidity of the tetramate system