Beilstein J. Org. Chem.2012,8, 398–402, doi:10.3762/bjoc.8.43
” reactions of aldehydes started as long ago as 1832, and the preparation of sterically hindered triazolium salts in 1996 provided a solid basis for highly stereoselective “umpolung” reactions utilizing NHCs [12]. In addition, conjugate “umpolung” relates to a process in which α,β-unsaturated aldehydes 3 are
anion 8 can deprotonate pentafluorophenyl triazolium salts 7 to give the free carbenes 5 and acetic acid 6, pointing to the peculiar conclusion that this carboxylic acid does not neutralize the carbenes (Scheme 3) [21]. Probably, the presence of the electron-withdrawing pentafluorophenyl group in
that the combination of a pentafluorophenyl triazolium carbene 5 and a Brønsted acid with low pKa value may provide new opportunities for the design of reaction pathways in which the carbene and the acid play different roles. The idea to use a very weak base in NHC catalysis has also been described by
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Graphical Abstract
Scheme 1:
Synthesis of the first free and stable N-heterocyclic carbene by Arduengo [2].
Beilstein J. Org. Chem.2012,8, 246–252, doi:10.3762/bjoc.8.25
state by X-ray crystallography. Alkylation gives the corresponding triazolium macrocycle, which binds chloride and benzoate strongly in CD3CN solution through favourable charge-assisted C–H···anion interactions, as evidenced by 1H NMR titration experiments. Preliminary electrochemical studies reveal
that the redox-active macrocycle is capable of sensing chloride in CH3CN solution.
Keywords: anion binding; C–H···anion interactions; electrochemistry; ferrocene; triazolium; Introduction
The copper(I)-catalysed cycloaddition of alkynes and azides (CuAAC) [1][2] to give the 1,2,3-triazole group is
][7]. More recently, we [8], and others [9][10], have shown that alkylating the triazole group to give the triazolium group increases the strength of anion binding significantly by further polarising the C–H bond of the heterocycle.
With one notable recent exception of an acyclic ferrocene-appended
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Graphical Abstract
Scheme 1:
Synthesis of bis(triazole) macrocycle 3 and tetra(triazole) macrocycle 4. Conditions and reagents: ...