An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid

• Biswajit K. Singh,
• Surendra S. Bisht and
• Rama P. Tripathi

Beilstein J. Org. Chem. 2006, 2, No. 24, doi:10.1186/1860-5397-2-24

• tetramic acid antibiotics with dienyl or polyenyl units are shown in Figure 1. 3-Acetyl tetramic acid derivatives are known to act as anti-HSV and anti-HIV agents with potent tyrosine phosphatase inhibitory activities. [10][11][12] The distinct structural features and pharmacological properties of tetramic