Beilstein J. Org. Chem.2024,20, 692–700, doi:10.3762/bjoc.20.63
fatty acyl groups. Furthermore, the variochelin biosynthetic gene cluster was identified through draft genome sequencing and gene knockout experiments. Compounds 1–5 exhibited antimicrobial activities against Gram-negative bacteria, including several soil-isolated plant pathogens.
Keywords
: antimicrobial activity; siderophore; variochelin; Variovorax; Introduction
Almost all organisms require iron as a crucial cofactor of enzymes essential for their physiological functions, encompassing primary and secondary metabolisms [1]. However, in an aerobic environment, iron predominantly exists in the
this study, we isolated three new congeners of variochelin-type siderophores, variochelins C–E (3–5), along with two known compounds, variochelins A (1) and B (2), from Variovorax sp. Their structures were elucidated by a combination of NMR, ESIMS/MS, and chemical derivatization. The analysis of the
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Graphical Abstract
Figure 1:
(a) Chemical structures and (b) ESIMS/MS of variochelins A–E (1–5) isolated from Variovorax sp. H00...