Beilstein J. Org. Chem.2020,16, 2929–2936, doi:10.3762/bjoc.16.242
that the C-(hetero)aryl-α-(arylamino)acetonitrile derivatives can be considered genotoxically safe and possibly antimutagenic.
Keywords: Ames test; α-aminoacetonitriles; ferrocene; phenothiazine; SEM; single crystal XRD; sonochemistry; Introduction
Sonochemistry can be considered as a major
-recognized Ames test to screen the mutagenic potential for three selected C-substituted α-aminoacetonitriles comprising different hetero(aromatic) units: phenothiazinyl (2c), ferrocenyl (2i), and phenyl (2l), respectively. The similarity of the tested aminoacetonitrile series was set aside by the N
toxicity effects are predictable for the new compounds 2c, 2i, and 2l at concentrations ranging at their solubility maxima.
The possible antimutagenic effect of the selected C-substituted α-aminoacetonitriles 2c, 2i, and 2l, respectively, in the presence of 2-aminoantracene, daunomycin (mutagens for TA 98