Beilstein J. Org. Chem.2020,16, 1022–1050, doi:10.3762/bjoc.16.91
pharmaceutical applications with a focus on published synthetic methods that introduce fluorine into the phenyl, the β-carbon or the α-carbon of ᴅ-or ʟ-phenylalanines.
Keywords: α-fluorophenylalanine; β- and β,β-difluorophenylalanine; fluorinated phenylalanines; PET; pharmaceuticals application; Introduction
with aqueous H2SO4. However, the acid hydrolysis step was accompanied with extensive racemization [81][83] (Scheme 42).
4. Synthesis of α-fluorophenylalanine of type V via α-fluorination of Phe derivatives
The successful α-fluorination of phenylalanine derivative 174 carrying a picolinamide auxiliary
auxiliary.
Synthesis of α-fluorophenylalanine derivatives via direct fluorination of protected Phe 174.
List of abbreviations.
Acknowledgements
L.F.A and M.S.A express sincere gratitude to Prof David O'Hagan for his support, also we are grateful to Faculty of Science, Alexandria University, Egypt.
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Graphical Abstract
Figure 1:
Categories I–V of fluorinated phenylalanines.