Asymmetric synthesis of a high added value chiral amine using immobilized ω-transaminases

• Antonella Petri,
• Valeria Colonna and
• Oreste Piccolo

Beilstein J. Org. Chem. 2019, 15, 60–66, doi:10.3762/bjoc.15.6

• prochiral precursor 1-Boc-3-piperidone using immobilized ω-transaminases (TAs-IMB), isopropylamine as amine donor and pyridoxal-5’-phosphate (PLP) as cofactor is described. Compared to other methods, the present approach affords the target compound in just one step with high yield and high enantiomeric

• sustainable approach to an industrial scale. Keywords: asymmetric catalysis; biotransformations; chiral amine; immobilized enzymes; ω-transaminases; Introduction Enantiomerically pure amines are important precursors to biologically active compounds with different industrial applications, including

• pharmaceuticals, fragrances and agricultural products [1]. It is therefore important to develop methods for their preparation which can be suitable for a large scale production. In this context there is an increasing interest in reactions including ω-transaminases (TAs) which have been identified as a greener and