Simple starts, complex ends: the power of one-pot chemistry

Organic synthesis has advanced remarkably in its ability to construct pharmaceutical ingredients, natural products, agrochemicals, ligand architectures, and functional building blocks for materials science. Yet many established methodologies still rely on labor-intensive protecting-group strategies and costly purification steps inherent to classical "stop-and-go" workflows. In light of this, our thematic issue aims to bring together contributions exploring how multicomponent/multistep one-pot and autonomous one-flask processes are improving efficiency, selectivity, and sustainability in modern synthesis.

Topics of interest include catalytic domino sequences, reaction cascades, streamlined protocols that eliminate intermediate isolation, sustainable reaction design, scalable catalytic systems, reaction triggering, selectivity control, mechanistic studies, and more. We particularly welcome contributions highlighting their applications, for example, in pharmaceutical and materials chemistry. Together, these themes are intended to showcase how multicomponent one-pot reactions are transforming synthetic strategies toward cleaner, faster, and more economical chemical production.

The thematic issue will cover, but is not limited to, the following:

• One-pot methodologies for sustainable synthesis
• Catalytic domino sequences and reaction cascades
• Protecting-group-free strategies and pot, atom, and step economy (PASE)
• Applications in pharmaceuticals and materials
• Mechanistic insights and selectivity control
• Green chemistry principles in multistep reactions
• Automation, integration, and future technologies in synthesis