Beilstein Organic Chemistry Symposium 2014: registration now open

The 2012 Impact Factor is 2.801 according to the Thomson Reuters Journal Citation Reports.


 
 

Organocatalytic C–H activation reactions

Subhas Chandra Pan
Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati, Assam, 781039, India
Email of corresponding author Corresponding author email     
This article is part of the Thematic Series "Organocatalysis".
Guest Editor: B. List
Beilstein J. Org. Chem. 2012, 8, 1374–1384.
doi:10.3762/bjoc.8.159

Article Information

Part of Thematic Series

Organocatalysis
 
 
 
 

Abstract

Organocatalytic C–H activation reactions have recently been developed besides the traditional metal-catalysed C–H activation reactions. The recent non-asymmetric and asymmetric C–H activation reactions mediated by organocatalysts are discussed in this review.

Keywords: asymmetric; C–H activation; non-asymmetric; organocatalysis; organocatalytic

Top

Introduction

C–H activation reactions have recently been found to be a powerful method for the formation of C–C and C–X bonds [1-3]. The advantage of this method is that it does not require the functional group of the carbon atom, as in the conventional approach. Transition-metal-catalysed C–H bond functionalization reactions have been well-studied and different site-selective (regioselective and chemoselective) reactions have been reported [1-3]. However, one drawback of this approach is the requirement of the removal of the metal impurity from the products. An organocatalytic approach is attractive in this sense as it is metal-free, cost-effective, and favoured by the pharmaceutical industry for being one of the “key green chemistry research areas” [4-6]. This review describes the current “state of the art” in organocatalyzed C–H activation reactions and highlights recent advances in sp2 and sp3 C–H bond functionalization. For simplicity, iodide or hypervalent iodine-mediated metal-free C–H transformations will not be covered in this review.

Top

Review

Organocatalytic sp3 C–H bond activation reactions

Non-asymmetric variants

tert-Amino effect: The “tert-amino effect” refers to the ring-closure reactions that proceed by redox processes for C–C and C–X bond formation within conjugated systems [7-9]. One well-known example of the “tert-amino effect” is the cyclization of N,N-dialkyl-substituted anilines with imines to generate cyclic aminals. The groups of Seidel and Akiyama independently reported mild organocatalytic approaches to cyclic aminals involving aminobenzaldehydes and primary amines [10,11]. Previously, only preformed imines were used for this purpose, and the reactions were mostly thermally controlled [12-15]. Seidel and co-workers found that the combination of triflic acid and ethanol provided an effective system for the formation of cyclic aminals (Scheme 1), whereas the combination of para-toluenesulfonic acid (PTSA) and benzene was the optimum system for Akiyama and co-workers (Scheme 2).

[1860-5397-8-159-i1]
Scheme 1: Triflic acid-catalysed synthesis of cyclic aminals.
[1860-5397-8-159-i2]
Scheme 2: PTSA-catalysed synthesis of cyclic aminals.

After evaluating different Lewis and Brønsted acids with their equivalents as well as different solvents, Seidel and co-workers found that 0.2 equivalents of triflic acid in ethanol under reflux provided the maximum yield of the desired product 1. The reaction was examined with different amines and moderate to good yields (35–75%) were obtained (Scheme 1) [10]. In certain cases, a stoichiometric amount of triflic acid was required to obtain acceptable yields of the desired products.

Akiyama and co-workers screened different Brønsted acid catalysts for their reaction, with PTSA emerging as the most effective catalyst [11]. Employing an optimized set of conditions, the reaction was conducted with different amines, and good to excellent yields (40–92%) were obtained (Scheme 2). A plausible mechanism for these reactions is depicted in Scheme 3.

[1860-5397-8-159-i3]
Scheme 3: Plausible mechanism for cyclic aminal synthesis.

After initial imine formation, a Brønsted acid promoted 1,5-hydride shift occurs yielding an imino-amine intermediate. Cyclization of the newly formed amine affords the desired aminal product.

In 2011, Seidel and co-workers reported an indole-annulation cascade reaction with N,N-(dialkylamino)benzaldehydes, a process in which a 1,5-hydride shift occurs followed by larger ring formation [16]. After the evaluation of different Brønsted acid catalysts, diphenylphosphate (20 mol %) was identified as a suitable catalyst for the reaction. Toluene again was the solvent of choice, and microwave irradiation was used for a shorter reaction time. The scope of the reactions was broad allowing different indoles and a variety of N,N-(dialkylamino)benzaldehydes to be employed, and the products 3 were obtained in good to excellent yields (Scheme 4) [16].

[1860-5397-8-159-i4]
Scheme 4: Annulation cascade reaction with double nucleophiles.

For some substrates, 50 mol % of the catalyst was required to obtain reasonable yields of the products. The authors also successfully extended this methodology to other double nucleophiles, i.e., 2,5-dimethylpyrroles and N,N’-diphenylhydrazine, and the products 4a and 4b were isolated in good yields (Scheme 4). A plausible mechanism was suggested by the authors and is shown in Scheme 5.

[1860-5397-8-159-i5]
Scheme 5: Mechanism for the indole-annulation cascade reaction.

Initially, the vinylogous iminium (azafulvenium) ion 5 is formed from the acid-catalyzed dehydration reaction of tertiary aminobenzaldehyde and indole (Scheme 5). Subsequently, 5 undergoes a 1,5-hydride shift to generate iminium ion 6. Finally, ring closure and proton loss provides the formation of the product 3.

Redox alkylation

In 2009, Tunge and co-workers demonstrated the synthesis of N-alkyl-pyrroles by redox isomerisation from the reaction of 3-pyrroline and aldehydes or ketones (Scheme 6) [17].

[1860-5397-8-159-i6]
Scheme 6: Synthesis of N-alkylpyrroles and δ-hydroxypyrroles.

A series of Brønsted acids as catalysts was screened for this reaction, and the best reaction efficiency in terms of yield and reaction time was achieved with benzoic acid (10 mol %). The scope of the reaction was investigated and was found to tolerate a wide variety of functional groups including nitro, nitriles, ether and acetals delivering the products 7 in good to excellent yields (50–94%). The reaction was also compatible with different ketones although extended reaction times were required to obtain good yields of the desired products. Interestingly, when the substrates were extended to five and six-membered lactols, δ-hydroxypyrroles 8 were achieved as the products in good yields (Scheme 6).

Later, Pan and Seidel independently extended this methodology to indolines using benzoic acid as the catalyst, conducting the reaction under reflux and microwave irradiation conditions, respectively, to generate indole 9 (Scheme 7) [18,19].

[1860-5397-8-159-i7]
Scheme 7: Synthesis of N-alkylindoles 9 and N-alkylindolines 10.

Only aryl aldehydes are able to perform the reaction, but the yields as reported by both groups are very good. Besides the usual reaction between indolines and aldehydes, both groups also found that intermolecular hydride transfer occurred when salicylaldehyde was employed as the substrate, and the N-alkyl-indoline product 10 was obtained in good yields (70–82%) mainly by the method of the Pan group (Scheme 7). In this case, another molecule of indoline acts as the hydride donor and is converted to indole.

Both Tunge and Pan suggested redox isomerization in the formation of their products, but did not provide a detailed mechanism. 1,3-Hydride shift could be the most direct pathway for the formation of the redox isomerization products. However, Seidel pointed out that a 1,3-hydride shift will occur antarafacially and is geometry-forbidden. An alternative explanation is the formation of azomethine ylide intermediate 11 (Scheme 8) [19,20].

[1860-5397-8-159-i8]
Scheme 8: Mechanistic study for the N-alkylpyrrole formation.

The carbanion of ylide 11 is then protonated by benzoic acid, and the resulting benzoate anion supports the aromatization process. In fact, Seidel and co-workers provided the experimental evidence for the existence of azomethine ylide intermediates in the Tunge pyrrole formation and in the formation of N-alkylindoles from indoline [19]. These reactions are considered C–H activation reactions, as during the azomethine ylide formation, the C–H bond that is cleaved is not activated by electron-withdrawing (such as ester) groups. Recently, Xue, Cheng and co-workers carried out detailed DFT and MP2 computational studies for the reaction of 3-pyrroline and 2-phenylpropanal using acetic acid as the catalyst [21]. Interestingly, the authors could not find the existence of free iminium ion 12 in the rearrangement. They indicated that the formation of acetic acid assisted azomethine ylide 13 is the most plausible pathway for the rearrangement process [21]. The first step is the nucleophilic addition of an amine to the carbonyl group to generate a carbinolamine intermediate (Scheme 8). It then becomes O-acetylated by acetic acid to form intermediate A. Azomethine ylide 13 is then produced by extrusion of acetic acid from intermediate A. Protonation of 13 generates another O-acetyl intermediate B, and finally, regeneration of acetic acid and aromatization provides the pyrrole product 7q. Pan and Seidel also independently disclosed examples of Brønsted acid catalysed decarboxylative redox-amination reactions. 2-Carboxyindoline and trans-4-hydroxyproline were used as the substrates, respectively [22,23]. Benzoic acid as catalyst and 1,4-dioxane as solvent was identified by the Pan group as the best system for the reaction (Scheme 9) [22].

[1860-5397-8-159-i9]
Scheme 9: Benzoic acid catalysed decarboxylative redox amination.

Different aromatic and heteroaromatic aldehydes were screened and N-alkylindole products 9 were isolated in moderate to good yields (62–82%). One current limitation of this method is its restriction to non-enolisable aldehydes. In contrast, Seidel and co-workers successfully applied both aromatic and enolisable aldehydes and ketones to their reaction and the desired N-alkylpyrrole products 7 were formed in moderate to good yields (42–73%) under microwave irradiation [23]. Both groups suggested azomethine ylide as the intermediate in their reactions (Scheme 9).

Asymmetric variants

The first organocatalytic asymmetric C–H activation reaction was disclosed by Kim and co-workers for the synthesis of chiral tetrahydroquinolines 14 (Scheme 10) [24].

[1860-5397-8-159-i10]
Scheme 10: Organocatalytic redox reaction of ortho-(dialkylamino)cinnamaldehydes.

ortho-(Dialkylamino)cinnamaldehydes were employed as the substrates for this aminocatalytic intramolecular redox reaction. The authors first demonstrated a non-asymmetric version of the reaction using pyrrolidine-TFA as catalyst in acetonitrile. High yields (67–98%) and moderate to good diastereoselectivities (59:41 to 80:20) were obtained for amine donors of different ring size [24]. After successfully performing the non-asymmetric synthesis of tetrahydroquinolines by C–H activation, the authors embarked on the asymmetric transformation utilizing chiral secondary amine catalysis. After the screening of different chiral amine catalysts, solvents, and acid additives, as well as temperatures, chiral pyrrolidine catalyst 15 in combination with (−)-camphorsulfonic acid (CSA) in 1,1,2-trichloroethane (TCE) at 20 °C provided the desired product in highest enantioselectivity (89% ee). Under the optimized conditions, a range of ortho-(dialkylamino)cinnamaldehydes were employed and chiral tetrahydroquinoline products 14 were obtained in moderate to good yields (37–75%), moderate to excellent diastereoselectivities (57:43 to 100:0 dr) and high to excellent enantioselectivities (85–99% ee) (Scheme 10) [24]. For some substrates, the reaction temperature was lowered to 0 or −20 °C in order to attain high enantioselectivities. A possible mechanism for the transformation is shown in Scheme 11.

[1860-5397-8-159-i11]
Scheme 11: Mechanism for aminocatalytic redox reaction of ortho-(dialkylamino)cinnamaldehydes.

At first, the secondary amine catalyst reacts with the α,β-unsaturated aldehyde to generate an iminium ion. Subsequent 1,5-hydride shift generates the corresponding enamine. Finally, Mannich-type cyclization provides the product 14, and the secondary amine catalyst is regenerated (Scheme 11).

The following year, Akiyama and co-workers reported another organocatalytic asymmetric synthesis of tetrahydroquinolines using chiral phosphoric acid as the catalyst [25]. In this instance, benzylidene malonates were used as the hydride acceptor. Another important feature of this report by the Akiyama group is the predominant use of N,N-dibenzylamine as the amine donor in their reaction instead of cyclic tertiary amines as used by the Kim group. The present authors employed biphenyl-based chiral phosphoric acid catalysts 15a and 15b and moderate to high yields (45–95%) and excellent enantioselectivities (70–97% ee, mostly above 90% ee) were achieved for different tetrahydroquinoline products 16 having gem-methyl ester groups (Scheme 12).

[1860-5397-8-159-i12]
Scheme 12: Asymmetric synthesis of tetrahydroquinolines having gem-methyl ester groups.

For substrates containing one N-benzyl group and one N-ethyl group, binaphthol-based catalyst 17 was used; however, no chemoselectivity (16j:16k = 1.2:1) was observed (Scheme 12). Also, catalyst 15b was used for the substrate having a N,N-diethyl group and product 16l was obtained with lower enantioselectivity (70% ee). The authors carried out a series of model experiments with chiral substrates (R)-18 and (S)-18 to gain insight into the mechanism of their reaction (Scheme 13) [25].

[1860-5397-8-159-i13]
Scheme 13: Asymmetric synthesis of tetrahydroquinolines from chiral substrates 18.

In the presence of catalyst 15a, (S)-18 underwent a smooth reaction to provide product 19 with 90% ee in favour of the (S)-isomer. In contrast, when (R)-18 was employed, the reaction was sluggish (10% yield) and only 68% ee of product 19 was observed in favour of the (R)-isomer. Even when achiral catalyst Yb(OTf)3 was used for the reaction with (S)-18, product 19 was obtained with 85% ee with the (S)-enantiomer as the major product. This clearly demonstrates that the chiral information in 18 did not disappear during the reaction and was retained as helical chirality in cationic intermediate C (Scheme 13). Nucleophilic attack then occurred from the same side of the transferred hydrogen to provide (S)-19. The authors concluded that selective activation of one of the enantiotopic hydrogen atoms by chiral phosphoric acid is the main reason for obtaining enantioselectivity for their reaction [25].

Organocatalytic sp2 C–H bond activation reactions

The catalytic cross-coupling of arenes and aryl halides to construct biaryl compounds is an important area in synthetic organic chemistry. Transition-metal-catalyzed biaryl synthesis from unactivated arenes by C–H activation is well-known in the literature [26-30]. Stoichiometric amounts of a radical source, such as tributyltin hydride and tris(trimethylsilyl)silicon hydride [31], or irradiation [32] were also utilized for biaryl synthesis from unactivated arenes. However, organocatalysts have not been studied for this class of transformation. In 2010, three research groups independently reported organocatalytic biaryl synthesis from unactivated arenes and aryl halides [33-35]. Since these reactions follow a homolytic radical aromatic substitution mechanism (HAS) as pointed out by Studer and Curran [36], they are better termed as “organocatalytic direct arylations of arenes” rather than “C–H activation reactions”. Kwong, Lei and co-workers initially carried out the reaction between 4-iodotoluene and benzene with different bases and catalysts at 80 °C [33]. After varying bases and catalysts, potassium tert-butoxide (1.0 equiv) and DMEDA (N,N’-dimethylethane-1,2-diamine) were found to be the best base and catalyst, respectively, providing the desired product 20 in 84% yield (Scheme 14).

[1860-5397-8-159-i14]
Scheme 14: Organocatalytic biaryl synthesis by Kwong, Lei and co-workers.

It is remarkable that cis-cyclohexane-1,2-diol is also a good catalyst for this reaction (81% yield). Under the optimized conditions, different aryl iodides were tested and good to excellent yields (38–92%) were obtained [33]. Dihalobenzenes were also employed as substrates, and poor to good yields (29–79%) for the products 21 were observed (Scheme 14). However, the reaction failed with anisole and toluene under the same reaction conditions.

Shi and co-workers reported a similar reaction with 1,10-phenanthroline as catalyst at 100 °C employing aryl iodides and aryl bromides as the substrates [34]. Whereas 40 mol % of the catalyst and 3.0 equivalents of potassium tert-butoxide as base were needed for the reaction with bromides, 20 mol % of the catalyst and 2.0 equivalents of potassium tert-butoxide were required for the reaction with iodides. Under these optimized conditions, different aryl bromides and aryl iodides were screened, and poor to good yields (27–89%) for the products 20 were observed (Scheme 15) [34].

[1860-5397-8-159-i15]
Scheme 15: Organocatalytic biaryl synthesis by Shi and co-workers.

It is interesting that different arenes were also explored under the reaction conditions, and poor to good yields (26–81%) were attained for the desired products 22. The authors found a decreased reactivity with increased electron density in the arenes; however, better conversion was obtained after long reaction time (2 days) at higher temperature (120 °C). The authors also discovered an intramolecular version of their reaction employing 1-(benzyloxy)-2-bromobenzene as the substrate in mesitylene as solvent, and 73% yield of the cyclized product 23 was obtained (Scheme 15).

The third report of organocatalytic biaryl synthesis came from the group of Hayashi [35]. The combination of 4,7-diphenylphenanthroline (Ph-phen) as catalyst and sodium tert-butoxide as base at 155 °C was identified as the best system for their reaction. The authors applied their arylation method to different aryl and heteroaryl iodides as well as bromides, and poor to good yields (13–82%) for products 20 were obtained (Scheme 16) [35].

[1860-5397-8-159-i16]
Scheme 16: Organocatalytic biaryl synthesis by Hayashi and co-workers.

A variety of electron-donating and -withdrawing substituents were incorporated on the arene part and high ortho-selectivities were observed for the products 22. The authors also investigated the reaction mechanism by performing a model reaction between 4-iodotoluene and THF-d8 with 20 equivalents of sodium tert-butoxide and Ph-phen (1 equiv) at 100 °C (Scheme 16). The formation of 4-deuterotoluene (23) implied the generation of a tolyl radical in the reaction, which finally abstracts a deuterium radical from THF-d8 to provide 23. The authors found a low conversion (2%) for 23 in the absence of Ph-phen indicating the involvement of Ph-phen in the radical generation. The authors explained that Ph-phen can act as a single-electron-transfer (SET) mediator because it has a low lying LUMO and thus accepts an electron to generate a radical anion, and then passes the electron to aryl halide [35].

A general mechanism for the organocatalytic cross-coupling reactions was proposed by Studer and Curran [36], which suggests a “base-promoted homolytic aromatic substitution” mechanism. In the first step, a phenyl radical generated from iodobenzene reacts with benzene to afford phenylcyclohexadienyl radical (24) (Scheme 17).

[1860-5397-8-159-i17]
Scheme 17: Proposed mechanism for organocatalytic biaryl synthesis.

Radical 24 is then deprotonated by potassium tert-butoxide to generate the biphenyl radical anion (25), potentially promoted by an organocatalyst. In the last step, radical anion 25, a strong reducing agent, transfers one electron to starting iodobenzene and results in the formation of biphenyl, potassium iodide and phenyl radical (Scheme 17). However, the role of the organocatalyst is still not fully understood at this point and detailed mechanistic studies are ongoing.

Top

Conclusion

In summary, this review highlights the recent developments of organocatalytic C–H activation reactions. Organocatalysts have been involved in 1,5-hydride shift and decarboxylative/non-decarboxylative redox-amination processes. Asymmetric organocatalytic C–H activation reactions have also been developed for the synthesis of chiral tetrahydroquinolines. Additionally, organocatalytic direct biaryl synthesis has been discovered; however, these are not considered to be “true” C–H activation reactions. It will be interesting to see true organocatalytic sp2 C–H activations in future, and more organocatalytic non-asymmetric and asymmetric sp3 C–H activation processes are expected [37].

Top

References

  1. Yu, J.-Q.; Shi, Z., Eds. Top. Curr. Chem.; 2010; Vol. 292, pp 1–345. doi:10.1007/978-3-642-12356-6
    Return to citation in text: [1] [2]
  2. Carbtree, R. H., Ed. Selective functionalization of C–H bonds. Chem. Rev. 2010, 110, 575–1211. doi:10.1021/cr900388d
    Return to citation in text: [1] [2]
  3. Davies, H. M. L.; Du Bois, J.; Yu, J.-Q., Eds. C–H Functionalization in organic sysnthesis. Chem. Soc. Rev. 2011, 40, 1845–2040. doi:10.1039/c1cs90010b
    Return to citation in text: [1] [2]
  4. Dalko, P. I.; Moisan, L. Angew. Chem., Int. Ed. 2004, 43, 5138–5175. doi:10.1002/anie.200400650
    Return to citation in text: [1]
  5. List, B.; Yang, J. W. Science 2006, 313, 1584–1586. doi:10.1126/science.1131945
    Return to citation in text: [1]
  6. MacMillan, D. W. C. Nature 2008, 455, 304–308. doi:10.1038/nature07367
    Return to citation in text: [1]
  7. Meth-Cohn, O. Adv. Heterocycl. Chem. 1996, 65, 1–37. doi:10.1016/S0065-2725(08)60294-9
    Return to citation in text: [1]
  8. Quintela, J. M. Recent Res. Dev. Org. Chem. 2003, 7, 259–278.
    Return to citation in text: [1]
  9. Mátyus, P.; Éliás, O.; Topolcsányi, P.; Polonka-Bálint, A.; Halász-Dajka, B. Synthesis 2006, 2625–2639. doi:10.1055/s-2006-942490
    Return to citation in text: [1]
  10. Zhang, C.; Murarka, S.; Seidel, D. J. Org. Chem. 2009, 74, 419–422. doi:10.1021/jo802325x
    Return to citation in text: [1] [2]
  11. Mori, K.; Ohshima, Y.; Ehara, K.; Akiyama, T. Chem. Lett. 2009, 38, 524–525. doi:10.1246/cl.2009.524
    Return to citation in text: [1] [2]
  12. Grantham, R. K.; Meth-Cohn, O. J. Chem. Soc. C 1969, 1444–1448. doi:10.1039/J39690001444
    Return to citation in text: [1]
  13. Clark-Lewis, J. W.; Moody, K.; Thompson, M. J. Aust. J. Chem. 1970, 23, 1249–1273. doi:10.1071/CH9701249
    Return to citation in text: [1]
  14. Ryabukhin, S. V.; Plaskon, A. S.; Volochnyuk, D. M.; Shivanyuk, A. N.; Tolmachev, A. A. J. Org. Chem. 2007, 72, 7417–7419. doi:10.1021/jo0712087
    Return to citation in text: [1]
  15. Che, X.; Zheng, L.; Dang, Q.; Bai, X. Synlett 2008, 2373–2375. doi:10.1055/s-2008-1078212
    Return to citation in text: [1]
  16. Haibach, M. C.; Deb, I.; De, C. K.; Seidel, D. J. Am. Chem. Soc. 2011, 133, 2100–2103. doi:10.1021/ja110713k
    Return to citation in text: [1] [2]
  17. Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; Tunge, J. A. J. Am. Chem. Soc. 2009, 131, 16626–16627. doi:10.1021/ja907357g
    Return to citation in text: [1]
  18. Mao, H.; Xu, R.; Wan, J.; Jiang, Z.; Sun, C.; Pan, Y. Chem.–Eur. J. 2010, 16, 13352–13355. doi:10.1002/chem.201001896
    Return to citation in text: [1]
  19. Deb, I.; Das, D.; Seidel, D. Org. Lett. 2011, 13, 812–815. doi:10.1021/ol1031359
    Return to citation in text: [1] [2] [3]
  20. Zhang, C.; Das, D.; Seidel, D. Chem. Sci. 2011, 2, 233–236. doi:10.1039/c0sc00432d
    Return to citation in text: [1]
  21. Xue, X.; Yu, A.; Cai, Y.; Cheng, J.-P. Org. Lett. 2011, 13, 6054–6057. doi:10.1021/ol2025247
    Return to citation in text: [1] [2]
  22. Mao, H.; Wang, S.; Yu, P.; Lv, H.; Xu, R.; Pan, Y. J. Org. Chem. 2011, 76, 1167–1169. doi:10.1021/jo102218v
    Return to citation in text: [1] [2]
  23. Deb, I.; Coiro, D. J.; Seidel, D. Chem. Commun. 2011, 47, 6473–6475. doi:10.1039/c1cc11560j
    Return to citation in text: [1] [2]
  24. Kang, Y. K.; Kim, S. M.; Kim, D. Y. J. Am. Chem. Soc. 2010, 132, 11847–11849. doi:10.1021/ja103786c
    Return to citation in text: [1] [2] [3]
  25. Mori, K.; Ehara, K.; Kurihara, K.; Akiyama, T. J. Am. Chem. Soc. 2011, 133, 6166–6169. doi:10.1021/ja2014955
    Return to citation in text: [1] [2] [3]
  26. de Meijere, A.; Diedrich, F. Metal-Catalyzed Cross-Coupling Reactions; Wiley-VCH: Weinheim, Germany, 2004.
    Return to citation in text: [1]
  27. McGlacken, G. P.; Bateman, L. M. Chem. Soc. Rev. 2009, 38, 2447–2464. doi:10.1039/b805701j
    Return to citation in text: [1]
  28. Daugulis, O.; Do, H.-Q.; Shabashov, D. Acc. Chem. Res. 2009, 42, 1074–1086. doi:10.1021/ar9000058
    Return to citation in text: [1]
  29. Alberico, D.; Scott, M. E.; Lautens, M. Chem. Rev. 2007, 107, 174–238. doi:10.1021/cr0509760
    Return to citation in text: [1]
  30. Li, B.-J.; Yang, S.-D.; Shi, Z.-J. Synlett 2008, 949–957. doi:10.1055/s-2008-1042907
    Return to citation in text: [1]
  31. Curran, D. P.; Keller, A. I. J. Am. Chem. Soc. 2006, 128, 13706–13707. doi:10.1021/ja066077q
    Return to citation in text: [1]
  32. Sharma, R. K.; Kharasch, N. Angew. Chem., Int. Ed. Engl. 1968, 7, 36–44. doi:10.1002/anie.196800361
    Return to citation in text: [1]
  33. Liu, W.; Cao, H.; Zhang, H.; Zhang, H.; Chung, K. H.; He, C.; Wang, H.; Kwong, F. Y.; Lei, A. J. Am. Chem. Soc. 2010, 132, 16737–16740. doi:10.1021/ja103050x
    Return to citation in text: [1] [2] [3]
  34. Sun, C.-L.; Li, H.; Yu, D.-G.; Yu, M.; Zhou, X.; Lu, X.-Y.; Huang, K.; Zheng, S.-F.; Li, B.-J.; Shi, Z.-J. Nat. Chem. 2010, 2, 1044–1049. doi:10.1038/nchem.862
    Return to citation in text: [1] [2] [3]
  35. Shirakawa, E.; Itoh, K.-i.; Higashino, T.; Hayashi, T. J. Am. Chem. Soc. 2010, 132, 15537–15539. doi:10.1021/ja1080822
    Return to citation in text: [1] [2] [3] [4]
  36. Studer, A.; Curran, D. P. Angew. Chem., Int. Ed. 2011, 50, 5018–5022. doi:10.1002/anie.201101597
    Return to citation in text: [1] [2]
  37. Jiao, Z.-W.; Zhang, S.-Y.; He, C.; Tu, Y.-Q.; Wang, S.-H.; Zhang, F.-M.; Zhang, Y.-Q.; Li, H. Angew. Chem., Int. Ed. 2012, in press. doi:10.1002/anie.201204274
    Return to citation in text: [1]
Top
Scheme 1: Triflic acid-catalysed synthesis of cyclic aminals. Move  Close
Scheme 2: PTSA-catalysed synthesis of cyclic aminals. Move  Close
Scheme 3: Plausible mechanism for cyclic aminal synthesis. Move  Close
Scheme 4: Annulation cascade reaction with double nucleophiles. Move  Close
Scheme 5: Mechanism for the indole-annulation cascade reaction. Move  Close
Scheme 6: Synthesis of N-alkylpyrroles and δ-hydroxypyrroles. Move  Close
Scheme 7: Synthesis of N-alkylindoles 9 and N-alkylindolines 10. Move  Close
Scheme 8: Mechanistic study for the N-alkylpyrrole formation. Move  Close
Scheme 9: Benzoic acid catalysed decarboxylative redox amination. Move  Close
Scheme 10: Organocatalytic redox reaction of ortho-(dialkylamino)cinnamaldehydes. Move  Close
Scheme 11: Mechanism for aminocatalytic redox reaction of ortho-(dialkylamino)cinnamaldehydes. Move  Close
Scheme 12: Asymmetric synthesis of tetrahydroquinolines having gem-methyl ester groups. Move  Close
Scheme 13: Asymmetric synthesis of tetrahydroquinolines from chiral substrates 18. Move  Close
Scheme 14: Organocatalytic biaryl synthesis by Kwong, Lei and co-workers. Move  Close
Scheme 15: Organocatalytic biaryl synthesis by Shi and co-workers. Move  Close
Scheme 16: Organocatalytic biaryl synthesis by Hayashi and co-workers. Move  Close
Scheme 17: Proposed mechanism for organocatalytic biaryl synthesis. Move  Close
37.Jiao, Z.-W.; Zhang, S.-Y.; He, C.; Tu, Y.-Q.; Wang, S.-H.; Zhang, F.-M.; Zhang, Y.-Q.; Li, H. Angew. Chem., Int. Ed. 2012, in press. doi:10.1002/anie.201204274
Go to reference 37
23.Deb, I.; Coiro, D. J.; Seidel, D. Chem. Commun. 2011, 47, 6473–6475. doi:10.1039/c1cc11560j
Go to reference 23
22.Mao, H.; Wang, S.; Yu, P.; Lv, H.; Xu, R.; Pan, Y. J. Org. Chem. 2011, 76, 1167–1169. doi:10.1021/jo102218v
Go to reference 22
22.Mao, H.; Wang, S.; Yu, P.; Lv, H.; Xu, R.; Pan, Y. J. Org. Chem. 2011, 76, 1167–1169. doi:10.1021/jo102218v
23.Deb, I.; Coiro, D. J.; Seidel, D. Chem. Commun. 2011, 47, 6473–6475. doi:10.1039/c1cc11560j
Go to references 22,23
26.de Meijere, A.; Diedrich, F. Metal-Catalyzed Cross-Coupling Reactions; Wiley-VCH: Weinheim, Germany, 2004.
27.McGlacken, G. P.; Bateman, L. M. Chem. Soc. Rev. 2009, 38, 2447–2464. doi:10.1039/b805701j
28.Daugulis, O.; Do, H.-Q.; Shabashov, D. Acc. Chem. Res. 2009, 42, 1074–1086. doi:10.1021/ar9000058
29.Alberico, D.; Scott, M. E.; Lautens, M. Chem. Rev. 2007, 107, 174–238. doi:10.1021/cr0509760
30.Li, B.-J.; Yang, S.-D.; Shi, Z.-J. Synlett 2008, 949–957. doi:10.1055/s-2008-1042907
Go to references 26-30
31.Curran, D. P.; Keller, A. I. J. Am. Chem. Soc. 2006, 128, 13706–13707. doi:10.1021/ja066077q
Go to reference 31
25.Mori, K.; Ehara, K.; Kurihara, K.; Akiyama, T. J. Am. Chem. Soc. 2011, 133, 6166–6169. doi:10.1021/ja2014955
Go to reference 25
25.Mori, K.; Ehara, K.; Kurihara, K.; Akiyama, T. J. Am. Chem. Soc. 2011, 133, 6166–6169. doi:10.1021/ja2014955
Go to reference 25
24.Kang, Y. K.; Kim, S. M.; Kim, D. Y. J. Am. Chem. Soc. 2010, 132, 11847–11849. doi:10.1021/ja103786c
Go to reference 24
25.Mori, K.; Ehara, K.; Kurihara, K.; Akiyama, T. J. Am. Chem. Soc. 2011, 133, 6166–6169. doi:10.1021/ja2014955
Go to reference 25
24.Kang, Y. K.; Kim, S. M.; Kim, D. Y. J. Am. Chem. Soc. 2010, 132, 11847–11849. doi:10.1021/ja103786c
Go to reference 24
24.Kang, Y. K.; Kim, S. M.; Kim, D. Y. J. Am. Chem. Soc. 2010, 132, 11847–11849. doi:10.1021/ja103786c
Go to reference 24
11.Mori, K.; Ohshima, Y.; Ehara, K.; Akiyama, T. Chem. Lett. 2009, 38, 524–525. doi:10.1246/cl.2009.524
Go to reference 11
16.Haibach, M. C.; Deb, I.; De, C. K.; Seidel, D. J. Am. Chem. Soc. 2011, 133, 2100–2103. doi:10.1021/ja110713k
Go to reference 16
12.Grantham, R. K.; Meth-Cohn, O. J. Chem. Soc. C 1969, 1444–1448. doi:10.1039/J39690001444
13.Clark-Lewis, J. W.; Moody, K.; Thompson, M. J. Aust. J. Chem. 1970, 23, 1249–1273. doi:10.1071/CH9701249
14.Ryabukhin, S. V.; Plaskon, A. S.; Volochnyuk, D. M.; Shivanyuk, A. N.; Tolmachev, A. A. J. Org. Chem. 2007, 72, 7417–7419. doi:10.1021/jo0712087
15.Che, X.; Zheng, L.; Dang, Q.; Bai, X. Synlett 2008, 2373–2375. doi:10.1055/s-2008-1078212
Go to references 12-15
10.Zhang, C.; Murarka, S.; Seidel, D. J. Org. Chem. 2009, 74, 419–422. doi:10.1021/jo802325x
Go to reference 10
7.Meth-Cohn, O. Adv. Heterocycl. Chem. 1996, 65, 1–37. doi:10.1016/S0065-2725(08)60294-9
8.Quintela, J. M. Recent Res. Dev. Org. Chem. 2003, 7, 259–278.
9.Mátyus, P.; Éliás, O.; Topolcsányi, P.; Polonka-Bálint, A.; Halász-Dajka, B. Synthesis 2006, 2625–2639. doi:10.1055/s-2006-942490
Go to references 7-9
10.Zhang, C.; Murarka, S.; Seidel, D. J. Org. Chem. 2009, 74, 419–422. doi:10.1021/jo802325x
11.Mori, K.; Ohshima, Y.; Ehara, K.; Akiyama, T. Chem. Lett. 2009, 38, 524–525. doi:10.1246/cl.2009.524
Go to references 10,11
1.Yu, J.-Q.; Shi, Z., Eds. Top. Curr. Chem.; 2010; Vol. 292, pp 1–345. doi:10.1007/978-3-642-12356-6
2.Carbtree, R. H., Ed. Selective functionalization of C–H bonds. Chem. Rev. 2010, 110, 575–1211. doi:10.1021/cr900388d
3.Davies, H. M. L.; Du Bois, J.; Yu, J.-Q., Eds. C–H Functionalization in organic sysnthesis. Chem. Soc. Rev. 2011, 40, 1845–2040. doi:10.1039/c1cs90010b
Go to references 1-3
4.Dalko, P. I.; Moisan, L. Angew. Chem., Int. Ed. 2004, 43, 5138–5175. doi:10.1002/anie.200400650
5.List, B.; Yang, J. W. Science 2006, 313, 1584–1586. doi:10.1126/science.1131945
6.MacMillan, D. W. C. Nature 2008, 455, 304–308. doi:10.1038/nature07367
Go to references 4-6
33.Liu, W.; Cao, H.; Zhang, H.; Zhang, H.; Chung, K. H.; He, C.; Wang, H.; Kwong, F. Y.; Lei, A. J. Am. Chem. Soc. 2010, 132, 16737–16740. doi:10.1021/ja103050x
34.Sun, C.-L.; Li, H.; Yu, D.-G.; Yu, M.; Zhou, X.; Lu, X.-Y.; Huang, K.; Zheng, S.-F.; Li, B.-J.; Shi, Z.-J. Nat. Chem. 2010, 2, 1044–1049. doi:10.1038/nchem.862
35.Shirakawa, E.; Itoh, K.-i.; Higashino, T.; Hayashi, T. J. Am. Chem. Soc. 2010, 132, 15537–15539. doi:10.1021/ja1080822
Go to references 33-35
32.Sharma, R. K.; Kharasch, N. Angew. Chem., Int. Ed. Engl. 1968, 7, 36–44. doi:10.1002/anie.196800361
Go to reference 32
1.Yu, J.-Q.; Shi, Z., Eds. Top. Curr. Chem.; 2010; Vol. 292, pp 1–345. doi:10.1007/978-3-642-12356-6
2.Carbtree, R. H., Ed. Selective functionalization of C–H bonds. Chem. Rev. 2010, 110, 575–1211. doi:10.1021/cr900388d
3.Davies, H. M. L.; Du Bois, J.; Yu, J.-Q., Eds. C–H Functionalization in organic sysnthesis. Chem. Soc. Rev. 2011, 40, 1845–2040. doi:10.1039/c1cs90010b
Go to references 1-3
33.Liu, W.; Cao, H.; Zhang, H.; Zhang, H.; Chung, K. H.; He, C.; Wang, H.; Kwong, F. Y.; Lei, A. J. Am. Chem. Soc. 2010, 132, 16737–16740. doi:10.1021/ja103050x
Go to reference 33
19.Deb, I.; Das, D.; Seidel, D. Org. Lett. 2011, 13, 812–815. doi:10.1021/ol1031359
20.Zhang, C.; Das, D.; Seidel, D. Chem. Sci. 2011, 2, 233–236. doi:10.1039/c0sc00432d
Go to references 19,20
33.Liu, W.; Cao, H.; Zhang, H.; Zhang, H.; Chung, K. H.; He, C.; Wang, H.; Kwong, F. Y.; Lei, A. J. Am. Chem. Soc. 2010, 132, 16737–16740. doi:10.1021/ja103050x
Go to reference 33
19.Deb, I.; Das, D.; Seidel, D. Org. Lett. 2011, 13, 812–815. doi:10.1021/ol1031359
Go to reference 19
34.Sun, C.-L.; Li, H.; Yu, D.-G.; Yu, M.; Zhou, X.; Lu, X.-Y.; Huang, K.; Zheng, S.-F.; Li, B.-J.; Shi, Z.-J. Nat. Chem. 2010, 2, 1044–1049. doi:10.1038/nchem.862
Go to reference 34
21.Xue, X.; Yu, A.; Cai, Y.; Cheng, J.-P. Org. Lett. 2011, 13, 6054–6057. doi:10.1021/ol2025247
Go to reference 21
34.Sun, C.-L.; Li, H.; Yu, D.-G.; Yu, M.; Zhou, X.; Lu, X.-Y.; Huang, K.; Zheng, S.-F.; Li, B.-J.; Shi, Z.-J. Nat. Chem. 2010, 2, 1044–1049. doi:10.1038/nchem.862
Go to reference 34
21.Xue, X.; Yu, A.; Cai, Y.; Cheng, J.-P. Org. Lett. 2011, 13, 6054–6057. doi:10.1021/ol2025247
Go to reference 21
35.Shirakawa, E.; Itoh, K.-i.; Higashino, T.; Hayashi, T. J. Am. Chem. Soc. 2010, 132, 15537–15539. doi:10.1021/ja1080822
Go to reference 35
35.Shirakawa, E.; Itoh, K.-i.; Higashino, T.; Hayashi, T. J. Am. Chem. Soc. 2010, 132, 15537–15539. doi:10.1021/ja1080822
Go to reference 35
16.Haibach, M. C.; Deb, I.; De, C. K.; Seidel, D. J. Am. Chem. Soc. 2011, 133, 2100–2103. doi:10.1021/ja110713k
Go to reference 16
35.Shirakawa, E.; Itoh, K.-i.; Higashino, T.; Hayashi, T. J. Am. Chem. Soc. 2010, 132, 15537–15539. doi:10.1021/ja1080822
Go to reference 35
17.Pahadi, N. K.; Paley, M.; Jana, R.; Waetzig, S. R.; Tunge, J. A. J. Am. Chem. Soc. 2009, 131, 16626–16627. doi:10.1021/ja907357g
Go to reference 17
36.Studer, A.; Curran, D. P. Angew. Chem., Int. Ed. 2011, 50, 5018–5022. doi:10.1002/anie.201101597
Go to reference 36
18.Mao, H.; Xu, R.; Wan, J.; Jiang, Z.; Sun, C.; Pan, Y. Chem.–Eur. J. 2010, 16, 13352–13355. doi:10.1002/chem.201001896
19.Deb, I.; Das, D.; Seidel, D. Org. Lett. 2011, 13, 812–815. doi:10.1021/ol1031359
Go to references 18,19
36.Studer, A.; Curran, D. P. Angew. Chem., Int. Ed. 2011, 50, 5018–5022. doi:10.1002/anie.201101597
Go to reference 36
© 2012 Pan; licensee Beilstein-Institut.
This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)

Table of Contents

Detailed