Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

Scholarly Works

• Spinelli, L.; D'Anna, P.; Morretta, E.; Cassiano, C.; Piccolo, V.; De Rosa, M.; Amico, R.; De Cicco, P.; Brancaccio, D.; Conte, C.; Zampella, A.; Quaglia, F.; Monti, M. C. PEGylation-Driven Remodeling of the Protein Corona on PLGA Nanoparticles: Implications for Macrophage Recognition. Biomacromolecules 2025. doi:10.1021/acs.biomac.5c01369
• Mi, S.; Du, Y.; Yuan, S.; Yu, H.; Guo, Y.; Cheng, Y.; Yao, W. Protein corona formation as a strategy for achieving SERS detection of orlistat and phenobarbital. Food Bioscience 2025, 72, 107428. doi:10.1016/j.fbio.2025.107428
• Ghosh, D.; Ji, Y.; Kaper, H.; de Vries, J.; Witjes, M. J.; van Rijn, P. Tailoring antifouling performance of zwitterionic nanogels through an advanced universal coating approach. Surfaces and Interfaces 2025, 72, 107084. doi:10.1016/j.surfin.2025.107084
• Neuhodov, Y.; Seminko, V.; Maksimchuk, P.; Grygorova, G.; Hubenko, K.; Kavok, N.; Dudetskaya, G.; Kot, Y.; Yefimova, S. Cerium oxide luminescent sensors for hydrogen peroxide detection with fetal bovine serum – enhanced sensitivity and aggregation stability in biological environments. Journal of Molecular Liquids 2025, 433, 127798. doi:10.1016/j.molliq.2025.127798
• Ahmadi, M.; Ayyoubzadeh, S. M.; Ardekani, S. A.; Ghaedrahmat, Z.; Masoumi, N.; Farnia, M. M.; Ghorbani-Bidkorpeh, F. A review on protein corona formation on nanoparticles and prediction of its composition using artificial intelligence tools. International journal of pharmaceutics 2025, 683, 126094. doi:10.1016/j.ijpharm.2025.126094
• van Straten, D.; van de Schepop, L.; Frunt, R.; Vader, P.; Schiffelers, R. M. Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles. Beilstein journal of nanotechnology 2025, 16, 740–748. doi:10.3762/bjnano.16.57
• Lins, A.; Keuter, L.; Mulac, D.; Humpf, H.-U.; Langer, K. Are stabilizers, located on the surface of PLGA nanoparticles, able to modify the protein adsorption pattern?. International journal of pharmaceutics 2025, 674, 125488. doi:10.1016/j.ijpharm.2025.125488
• Rennie, C.; Morshed, N.; Faria, M.; Collins-Praino, L.; Care, A. Nanoparticle Association with Brain Cells Is Augmented by Protein Coronas Formed in Cerebrospinal Fluid. Molecular pharmaceutics 2025, 22, 940–957. doi:10.1021/acs.molpharmaceut.4c01179
• Ferreira, N. N.; Leite, C. M.; Moreno, N. S.; Miranda, R. R.; Pincela Lins, P. M.; Rodero, C. F.; de Oliveira Junior, E.; Lima, E. M.; Reis, R. M.; Zucolotto, V. Nose-to-Brain Delivery of Biomimetic Nanoparticles for Glioblastoma Targeted Therapy. ACS applied materials & interfaces 2024, 17, 484–499. doi:10.1021/acsami.4c16837
• Kelle, D.; Speth, K. R.; Martínez-Negro, M.; Mailänder, V.; Landfester, K.; Iyisan, B. Effect of protein corona on drug release behavior of PLGA nanoparticles. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2024, 207, 114611. doi:10.1016/j.ejpb.2024.114611
• Crivaro, A. N.; Ceci, R.; Boztepe, T.; Cisneros, J. S.; Chain, C. Y.; Huck-Iriart, C.; Lamas, D. G.; Islan, G. A.; Rozenfeld, P. Effective encapsulation of therapeutic recombinant enzyme into polymeric nanoparticles as a potential vehicle for lysosomal disease treatment. International journal of biological macromolecules 2024, 285, 138248. doi:10.1016/j.ijbiomac.2024.138248
• Hulugalla, K.; Shofolawe-Bakare, O.; Toragall, V. B.; Mohammad, S. A.; Mayatt, R.; Hand, K.; Anderson, J.; Chism, C.; Misra, S. K.; Shaikh, T.; Tanner, E. E. L.; Smith, A. E.; Sharp, J. S.; Fitzkee, N. C.; Werfel, T. Glycopolymeric Nanoparticles Enrich Less Immunogenic Protein Coronas, Reduce Mononuclear Phagocyte Clearance, and Improve Tumor Delivery Compared to PEGylated Nanoparticles. ACS nano 2024, 18, 30540–30560. doi:10.1021/acsnano.4c08922
• Morshed, N.; Rennie, C.; Deng, W.; Collins-Praino, L.; Care, A. Serum-derived protein coronas affect nanoparticle interactions with brain cells. Nanotechnology 2024, 35, 495101. doi:10.1088/1361-6528/ad7b40
• Fu, X.; Yang, C.; Su, Y.; Liu, C.; Qiu, H.; Yu, Y.; Su, G.; Zhang, Q.; Wei, L.; Cui, F.; Zou, Q.; Zhang, Z. Machine Learning Enables Comprehensive Prediction of the Relative Protein Abundance of Multiple Proteins on the Protein Corona. Research (Washington, D.C.) 2024, 7, 0487. doi:10.34133/research.0487
• Schleyer, G.; Patterson, E. A.; Curran, J. M. Label free tracking to quantify nanoparticle diffusion through biological media. Scientific reports 2024, 14, 18822. doi:10.1038/s41598-024-69506-0
• van Straten, D.; Sork, H.; van de Schepop, L.; Frunt, R.; Ezzat, K.; Schiffelers, R. M. Biofluid specific protein coronas affect lipid nanoparticle behavior in vitro. Journal of controlled release : official journal of the Controlled Release Society 2024, 373, 481–492. doi:10.1016/j.jconrel.2024.07.044
• Douglas-Green, S. A.; Aleman, J. A.; Hammond, P. T. Electrophoresis-Based Approach for Characterizing Dendrimer-Protein Interactions: A Proof-of-Concept Study. ACS biomaterials science & engineering 2024, 10, 3747–3758. doi:10.1021/acsbiomaterials.3c01579
• Wilson, B. K.; Yang, H.; Prud'homme, R. K. Polyelectrolyte-Doped Block Copolymer-Stabilized Nanocarriers for Continuous Tunable Surface Charge. ACS Applied Nano Materials 2024, 7, 11071–11079. doi:10.1021/acsanm.3c02277
• Gül, D.; Önal Acet, B.; Lu, Q.; Stauber, R. H.; Odabaşı, M.; Acet, Ö. Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?. International journal of molecular sciences 2024, 25, 5171. doi:10.3390/ijms25105171
• Önal Acet, B.; Gül, D.; Stauber, R. H.; Odabaşı, M.; Acet, Ö. A Review for Uncovering the "Protein-Nanoparticle Alliance": Implications of the Protein Corona for Biomedical Applications. Nanomaterials (Basel, Switzerland) 2024, 14, 823. doi:10.3390/nano14100823

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