Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials

Stefania Ordanini, Wanda Celentano, Anna Bernardi and Francesco Cellesi

Beilstein J. Nanotechnol. 2019, 10, 2192–2206. https://doi.org/10.3762/bjnano.10.212

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Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials

Stefania Ordanini, Wanda Celentano, Anna Bernardi and Francesco Cellesi

Beilstein J. Nanotechnol. 2019, 10, 2192–2206. https://doi.org/10.3762/bjnano.10.212

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Ordanini, S.; Celentano, W.; Bernardi, A.; Cellesi, F. Beilstein J. Nanotechnol. 2019, 10, 2192–2206. doi:10.3762/bjnano.10.212

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TY  - JOUR
A1  - Ordanini, Stefania
A1  - Celentano, Wanda
A1  - Bernardi, Anna
A1  - Cellesi, Francesco
T1  - Mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) as multivalent lectin-binding nanomaterials
JF  - Beilstein Journal of Nanotechnology
PY  - 2019///
VL  - 10
SP  - 2192
EP  - 2206
SN  - 2190-4286
DO  - 10.3762/bjnano.10.212
PB  - Beilstein-Institut
JA  - Beilstein J. Nanotechnol.
UR  - https://doi.org/10.3762/bjnano.10.212
KW  - atom transfer radical polymerization (ATRP)
KW  - glycopolymer
KW  - lectin
KW  - poly(ethylene glycol)
KW  - poly(ε-caprolactone)
KW  - ring-opening polymerization (ROP)
N2  - A class of linear and four-arm mannosylated brush copolymers based on poly(ethylene glycol) and poly(ε-caprolactone) is presented here. The synthesis through ring-opening and atom transfer radical polymerizations provided high control over molecular weight and functionality. A post-polymerization azide–alkyne cycloaddition allowed for the formation of glycopolymers with different mannose valencies (1, 2, 4, and 8). In aqueous media, these macromolecules formed nanoparticles that were able to bind lectins, as investigated by concanavalin A binding assay. The results indicate that carbohydrate–lectin interactions can be tuned by the macromolecular architecture and functionality, hence the importance of these macromolecular properties in the design of targeted anti-pathogenic nanomaterials.
ER  -

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aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
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benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)