The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency

Arianna Gennari, Julio M. Rios de la Rosa, Erwin Hohn, Maria Pelliccia, Enrique Lallana, Roberto Donno, Annalisa Tirella and Nicola Tirelli
Beilstein J. Nanotechnol. 2019, 10, 2594–2608. https://doi.org/10.3762/bjnano.10.250

Supporting Information

Supporting Information File 1: Additional experimental description and data.
Format: PDF Size: 778.8 KB Download

Cite the Following Article

The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency
Arianna Gennari, Julio M. Rios de la Rosa, Erwin Hohn, Maria Pelliccia, Enrique Lallana, Roberto Donno, Annalisa Tirella and Nicola Tirelli
Beilstein J. Nanotechnol. 2019, 10, 2594–2608. https://doi.org/10.3762/bjnano.10.250

How to Cite

Gennari, A.; Rios de la Rosa, J. M.; Hohn, E.; Pelliccia, M.; Lallana, E.; Donno, R.; Tirella, A.; Tirelli, N. Beilstein J. Nanotechnol. 2019, 10, 2594–2608. doi:10.3762/bjnano.10.250

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 1.4 MB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Karthik, S.; Mohan, S.; Magesh, I.; Bharathy, A.; Kolipaka, R.; Ganesamoorthi, S.; Sathiya, K.; Shanmugavadivu, A.; Gurunathan, R.; Selvamurugan, N. Chitosan nanocarriers for non-coding RNA therapeutics: A review. International journal of biological macromolecules 2024, 263, 130361. doi:10.1016/j.ijbiomac.2024.130361
  • Rohtagi, P.; Garg, U.; Triveni; Jain, N.; Pandey, M.; Amin, M. C. I. M.; Gorain, B.; Kumar, P. Chitosan and hyaluronic acid-based nanocarriers for advanced cancer therapy and intervention. Biomaterials advances 2023, 157, 213733. doi:10.1016/j.bioadv.2023.213733
  • Mauri, E.; Scialla, S. Nanogels Based on Hyaluronic Acid as Potential Active Carriers for Dermatological and Cosmetic Applications. Cosmetics 2023, 10, 113. doi:10.3390/cosmetics10040113
  • Hogan, K. J.; Perez, M. R.; Mikos, A. G. Extracellular matrix component-derived nanoparticles for drug delivery and tissue engineering. Journal of controlled release : official journal of the Controlled Release Society 2023, 360, 888–912. doi:10.1016/j.jconrel.2023.07.034
  • Spadea, A.; Pingrajai, P.; Tirella, A. Hyaluronic Acid-Based Nanotechnologies for Delivery and Treatment. Biomedical Applications and Toxicity of Nanomaterials; Springer Nature Singapore, 2023; pp 103–128. doi:10.1007/978-981-19-7834-0_4
  • La Verde, G.; Sasso, A.; Rusciano, G.; Capaccio, A.; Fusco, S.; Mayol, L.; Biondi, M.; Silvestri, T.; Netti, P. A.; La Commara, M.; Panzetta, V.; Pugliese, M. Characterization of Hyaluronic Acid-Coated PLGA Nanoparticles by Surface-Enhanced Raman Spectroscopy. International journal of molecular sciences 2022, 24, 601. doi:10.3390/ijms24010601
  • Ładniak, A.; Jurak, M.; Wiącek, A. E. The effect of chitosan/TiO2/hyaluronic acid subphase on the behaviour of 1,2-dioleoyl-sn-glycero-3-phosphocholine membrane. Biomaterials advances 2022, 138, 212934. doi:10.1016/j.bioadv.2022.212934
  • Cannavà, C.; De Gaetano, F.; Stancanelli, R.; Venuti, V.; Paladini, G.; Caridi, F.; Ghica, C.; Crupi, V.; Majolino, D.; Ferlazzo, G.; Tommasini, S.; Ventura, C. A. Chitosan-Hyaluronan Nanoparticles for Vinblastine Sulfate Delivery: Characterization and Internalization Studies on K-562 Cells. Pharmaceutics 2022, 14, 942. doi:10.3390/pharmaceutics14050942
  • Chen, R.; Zhai, Y.-Y.; Sun, L.; Wang, Z.; Xia, X.; Yao, Q.; Kou, L. Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment. Asian journal of pharmaceutical sciences 2022, 17, 268–283. doi:10.1016/j.ajps.2022.02.003
  • Chiesa, E.; Greco, A.; Riva, F.; Dorati, R.; Conti, B.; Modena, T.; Genta, I. CD44-Targeted Carriers: The Role of Molecular Weight of Hyaluronic Acid in the Uptake of Hyaluronic Acid-Based Nanoparticles. Pharmaceuticals (Basel, Switzerland) 2022, 15, 103. doi:10.3390/ph15010103
  • Ventouri, I. K.; Loeber, S.; Somsen, G. W.; Schoenmakers, P. J.; Astefanei, A. Field-flow fractionation for molecular-interaction studies of labile and complex systems: A critical review. Analytica chimica acta 2021, 1193, 339396. doi:10.1016/j.aca.2021.339396
  • Chiesa, E.; Greco, A.; Riva, F.; Dorati, R.; Conti, B.; Modena, T.; Genta, I. Hyaluronic Acid-Based Nanoparticles for Protein Delivery: Systematic Examination of Microfluidic Production Conditions. Pharmaceutics 2021, 13, 1565. doi:10.3390/pharmaceutics13101565
  • Plucinski, A.; Lyu, Z.; Schmidt, B. V. K. J. Polysaccharide nanoparticles: From fabrication to applications. Journal of materials chemistry. B 2021, 9, 7030–7062. doi:10.1039/d1tb00628b
  • Lima, A. C.; Reis, R. L.; Ferreira, H.; Neves, N. M. Cellular Uptake of Three Different Nanoparticles in an Inflammatory Arthritis Scenario versus Normal Conditions. Molecular pharmaceutics 2021, 18, 3235–3246. doi:10.1021/acs.molpharmaceut.1c00066
  • Ramirez, L. M. F.; Rihouey, C.; Chaubet, F.; Le Cerf, D.; Picton, L. Characterization of dextran particle size: How frit-inlet asymmetrical flow field-flow fractionation (FI-AF4) coupled online with dynamic light scattering (DLS) leads to enhanced size distribution. Journal of chromatography. A 2021, 1653, 462404. doi:10.1016/j.chroma.2021.462404
  • Supachawaroj, N.; Damrongrungruang, T.; Limsitthichaikoon, S. Formulation development and evaluation of lidocaine hydrochloride loaded in chitosan-pectin-hyaluronic acid polyelectrolyte complex for dry socket treatment. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 2021, 29, 1070–1081. doi:10.1016/j.jsps.2021.07.007
  • Zhang, X.; Wei, D.; Xu, Y.; Zhu, Q. Hyaluronic acid in ocular drug delivery. Carbohydrate polymers 2021, 264, 118006. doi:10.1016/j.carbpol.2021.118006
  • Quattrini, F.; Berrecoso, G.; Crecente-Campo, J.; Alonso, M. J. Asymmetric flow field-flow fractionation as a multifunctional technique for the characterization of polymeric nanocarriers. Drug delivery and translational research 2021, 11, 373–395. doi:10.1007/s13346-021-00918-5
  • Niezabitowska, E.; Town, A. R.; Sabagh, B.; Moctezuma, M. D. M.; Kearns, V.; Spain, S. G.; Rannard, S. P.; McDonald, T. O. Insights into the internal structures of nanogels using a versatile asymmetric-flow field-flow fractionation method. Nanoscale advances 2020, 2, 4713–4721. doi:10.1039/d0na00314j
  • Lierová, A.; Kašparová, J.; Pejchal, J.; Kubelkova, K.; Jeličová, M.; Palarcik, J.; Korecká, L.; Bílková, Z.; Šinkorová, Z. Attenuation of Radiation-Induced Lung Injury by Hyaluronic Acid Nanoparticles. Frontiers in pharmacology 2020, 11, 1199. doi:10.3389/fphar.2020.01199

Patents

  • GARTZIANDIA LÓPEZ DE GOIKOETXEA OIHANE; ALONSO CARNICERO JOSÉ; PÉREZ GONZÁLEZ RAÚL; MUÑOZ MORENTIN MANUEL. COMPOSITION COMPRISING SEA WATER AND CANNABINOID LOADED SUBMICROPARTICLES FOR PHARMACEUTICAL, NUTRACEUTICAL AND COSMETIC APPLICATIONS. WO 2022122471 A1, June 16, 2022.
Other Beilstein-Institut Open Science Activities