Internalization mechanisms of cell-penetrating peptides

Ivana Ruseska and Andreas Zimmer
Beilstein J. Nanotechnol. 2020, 11, 101–123. https://doi.org/10.3762/bjnano.11.10

Cite the Following Article

Internalization mechanisms of cell-penetrating peptides
Ivana Ruseska and Andreas Zimmer
Beilstein J. Nanotechnol. 2020, 11, 101–123. https://doi.org/10.3762/bjnano.11.10

How to Cite

Ruseska, I.; Zimmer, A. Beilstein J. Nanotechnol. 2020, 11, 101–123. doi:10.3762/bjnano.11.10

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 628.9 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Yamada, S.; Sasaki, E.; Ohno, H.; Nagase, K.; Hanaoka, K. Thermo-responsive targeting of polymeric micelles by controlling the cellular uptake based on the change of their surface arginine density. Communications Chemistry 2025, 8. doi:10.1038/s42004-025-01707-8
  • Yang, D.-M.; Kang, Y. W.; Kim, K.; Lee, S.-H.; Oh, T.; Shin, K. J.; Kim, M. J.; Heo, T.-H.; Kim, I. Discovery of novel indoline derivatives as potent small molecule PD-L1 inhibitors. Bioorganic & Medicinal Chemistry Letters 2025, 130458. doi:10.1016/j.bmcl.2025.130458
  • Aranda-Lara, L.; Escudero-Castellanos, A.; Trujillo-Nolasco, M.; Morales-Avila, E.; Ocampo-García, B.; Oros-Pantoja, R.; Sánchez-Monroy, V.; Isaac-Olivé, K. Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview. Pharmaceutics 2025, 17, 1408. doi:10.3390/pharmaceutics17111408
  • Malekzadeh, R.; Mahnam, K.; Karimzadeh, F.; Bahadorani, M.; Rezaee, M.; Ghatrehsamani, M.; Elahian, F.; Mirzaei, S. A. Design and development of anticancer peptide-conjugated daunorubicin: Smart targeting systems for multidrug resistance gastric cancer cells. Computers in biology and medicine 2025, 198, 111258. doi:10.1016/j.compbiomed.2025.111258
  • Milewski, S.; Wichrowska, W.; Milewska, M. J. Oligopeptides as molecular carriers in antimicrobial conjugates. Expert opinion on drug delivery 2025. doi:10.1080/17425247.2025.2581841
  • Krönke, T.; Trommer, J.; Ullrich, M.; Laube, M.; Löser, R.; Kretzschmar, J.; Urbanova, M.; Stadlbauer, S.; Brandt, F.; Platzek, I.; Hoberück, S.; Kotzerke, J.; Thomas, C.; Miederer, M.; Bundschuh, R. A.; Kopka, K.; Pietzsch, J.; Wodtke, R. "Precision on Two Wheels"─Structural Refinement of 64Cu- and 68Ga-Labeled Bicyclic Peptides Targeting Nectin-4 for Improved Tumor Imaging: From Preclinical Development to First-in-Human Application. Journal of medicinal chemistry 2025, 68, 21962–21987. doi:10.1021/acs.jmedchem.5c02371
  • Baghirov, H. Strategies for Transcytosis-Based Delivery across the Blood-Brain Barrier. Molecular pharmaceutics 2025, 22, 6400–6412. doi:10.1021/acs.molpharmaceut.5c01139
  • Karati, D.; Das, S.; Mitra, S. Peptide-Based Drugs: Emerging Treatment Strategies of Lung Cancer by Overcoming Chemoresistance. International Journal of Peptide Research and Therapeutics 2025, 31. doi:10.1007/s10989-025-10767-2
  • Mitra, S.; Das, S.; Mukherjee, S.; Karati, D.; Meur, S. Anticancer Therapy Against Glioma by Peptide-Based Therapeutics. International Journal of Peptide Research and Therapeutics 2025, 31. doi:10.1007/s10989-025-10755-6
  • Ghosh, S.; Arshi, M. U.; Ghosh, S.; Jash, M.; Mukherjee, N.; Jana, A.; Shastry, A.; Karanth, D.; Nishad, K.; Rana, N. K.; Bhattacharyya, S.; Ghosh, S. Advancing antisense oligonucleotide delivery through click chemistry based chemical conjugation with designed short non-cationic peptides for Duchenne muscular dystrophy. Methods (San Diego, Calif.) 2025, 244, 92–107. doi:10.1016/j.ymeth.2025.09.005
  • Jankowski, A. M.; Ensign, M. A.; Maisel, K. Cell-penetrating peptides as facilitators of cargo-specific nanocarrier-based drug delivery. Nanoscale 2025, 17, 20006–20019. doi:10.1039/d5nr00617a
  • Maroni, G.; Stojceski, F.; Pallante, L.; Deriu, M. A.; Piga, D.; Grasso, G. LightCPPgen: An explainable machine learning pipeline for rational design of cell penetrating peptides. International journal of antimicrobial agents 2025, 66, 107611. doi:10.1016/j.ijantimicag.2025.107611
  • Babar, T. K.; Glare, T. R.; Hampton, J. G.; Hurst, M. R. H.; Narciso, J. Heads or tails? An insight into the nature of antibacterial proteins of entomopathogenic bacteria. Advances in applied microbiology 2025, 132, 1–81. doi:10.1016/bs.aambs.2025.08.002
  • He, B.; Khemaissa, S.; Cardon, S.; Marquant, R.; Illien, F.; Ravault, D.; Burlina, F.; Sachon, E.; Walrant, A.; Sagan, S. Translocation of penetratin-like peptides involving calcium-dependent interactions between glycosaminoglycans and phosphocholine headgroups of the membrane lipid bilayer. RSC chemical biology 2025, 6, 1391–1402. doi:10.1039/d5cb00099h
  • Liu, D.; Zhang, M.; Li, M. Direct Cytosolic Uptake of Cell Penetrating Peptides with Shortened Sidechains. Chembiochem : a European journal of chemical biology 2025, 26, e202500391. doi:10.1002/cbic.202500391
  • Lee, Y.; Oh, B.; Kang, S.; Kim, S.; Kim, Y.-P. Engineering cyclized biomolecules for advanced diagnostic and therapeutic applications. Biotechnology advances 2025, 84, 108694. doi:10.1016/j.biotechadv.2025.108694
  • He, W.; Chen, C.; Zheng, J.; Li, Y.; Shi, H.; Zhou, Y.; Li, M.; Gong, P.; Liu, K.; Shao, X.; Yao, X.; Li, H.; Chen, L.; Fang, L. Targeted degradation of cell surface proteins through endocytosis triggered by cell-penetrating peptide-small molecule conjugates. Nature communications 2025, 16, 7575. doi:10.1038/s41467-025-62776-w
  • Choe, S. The role of polyproline in the membrane translocation of arginine-rich cell-penetrating peptides: A study based on molecular dynamics simulations. Springer Science and Business Media LLC 2025. doi:10.21203/rs.3.rs-7062405/v1
  • Gundam, S. R.; Kethamreddy, M.; González Rivera, A.; Bansal, A.; Krol, V.; Sahagun, D. A.; Kusmirek, J. E.; Johnson, D. R.; Zahid, M.; Lowe, V. J.; Pandey, M. K. Synthesis and preliminary evaluation of cardiac imaging with [68Ga]Ga-NOTA-CTP in normal and infarcted CD1 mice. RSC Pharmaceutics 2025, 2, 691–702. doi:10.1039/d5pm00047e
  • Bellavita, R.; Pecoraro, A.; Palladino, S.; Danisi, C.; Falanga, A.; D'Auria, G.; Falcigno, L.; Russo, G.; Galdiero, S.; Russo, A. Transport across membrane meets biophysics to unveil the mechanism of action of a novel gH625 analogue. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025, 212, 107204. doi:10.1016/j.ejps.2025.107204

Patents

  • NIJJAR TARLOCHAN S; TAM STEPHEN JED. METHODS, COMPOSITIONS, AND KITS INCLUDING CELL-PENETRATING AGENTS. WO 2025059491 A2, March 20, 2025.
  • NIJJAR TARLOCHAN S; TAM STEPHEN JED. CELL PENETRATING AGENTS AND USES THEREOF. WO 2025059515 A2, March 20, 2025.
  • NIJJAR TARLOCHAN S; TAM STEPHEN JED. CELL PENETRATING AGENTS AND USES THEREOF. WO 2025059487 A2, March 20, 2025.
  • SAITAKIS MICHAEL; AMIGORENA SEBASTIAN; FUENTEALBA JAIME RODRIGO; LOPEZ COBO SHEILA; ALCANTARA MARION; TSALKITZI KYRIAKI. COMPOSITIONS AND METHODS FOR TREATING A REFRACTORY OR RELAPSED CANCER OR A CHRONIC INFECTIOUS DISEASE. WO 2023222928 A2, Nov 23, 2023.
  • BLACKWOOD ERIK; GLEMBOTSKI CHRISTOPHER. SGK1 INHIBITORY COMPOSITIONS AND METHODS. WO 2023114714 A1, June 22, 2023.
Other Beilstein-Institut Open Science Activities