Internalization mechanisms of cell-penetrating peptides

Ivana Ruseska and Andreas Zimmer
Beilstein J. Nanotechnol. 2020, 11, 101–123. https://doi.org/10.3762/bjnano.11.10

Cite the Following Article

Internalization mechanisms of cell-penetrating peptides
Ivana Ruseska and Andreas Zimmer
Beilstein J. Nanotechnol. 2020, 11, 101–123. https://doi.org/10.3762/bjnano.11.10

How to Cite

Ruseska, I.; Zimmer, A. Beilstein J. Nanotechnol. 2020, 11, 101–123. doi:10.3762/bjnano.11.10

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 628.9 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Yu, L.; He, Y.; Liu, G.; Wei, Q.; Wang, R.; Wen, T.; Chen, J.; Gao, Q.; Wang, W.; Bai, H.; Wang, Y.; Fu, C.; Yu, Z.; Zhao, L.; Wei, M. A novel peptide–drug conjugate GV-K for anti-colorectal cancer therapy via mitochondrial apoptosis. Acta Pharmaceutica Sinica B 2026. doi:10.1016/j.apsb.2026.06.055
  • Kuo, C.-F.; Babayemi, T.; Dam, K. U.; Zheng, S.; Yang, H. W.; Sirianni, R. W. Ang2 and TAT targeting of leptomeningeal disease by the intravenous and intrathecal routes: a comparative analysis. openRxiv 2026. doi:10.64898/2026.06.29.735336
  • Merzlyakova, N.; Tikhonov, S.; Tikhonova, N.; Timofeeva, M.; Semin, A.; Kurdyumov, A.; Lylov, A. Oral Delivery of Bioactive Protein Molecules: Problems and Perspectives. Food Processing: Techniques and Technology 2026, 380–400. doi:10.21603/2074-9414-2026-2-2644
  • Liang, X.-H.; Zhang, L. The Versatile Applications of Antisense Oligonucleotides in Modern Medicine. International journal of molecular sciences 2026, 27, 5612. doi:10.3390/ijms27125612
  • Trofimenko, E.; Gervasi, N.; Perez, S.; Rodriguez, N.; Ravault, D.; Cribier, S.; Berry, H.; Venance, L.; Sagan, S. Transient pores account for cell-penetrating peptide and homeoprotein translocation. Proceedings of the National Academy of Sciences of the United States of America 2026, 123, e2602649123. doi:10.1073/pnas.2602649123
  • Malek-Khatabi, A.; Rahimzadegan, M.; Razavi, M. S.; Shabankareh, A. N. T.; Sefat, F.; Nosrati, R. Cell-penetrating peptides (CPPs)-engineered PLGA nanocarriers for enhanced drug delivery: Uptake mechanisms, optimization strategies, and therapeutic applications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2026, 201, 119631. doi:10.1016/j.biopha.2026.119631
  • Zaric, B. L.; Khodahemmati, S.; Zafirovic, S. S.; Isenovic, E. R. Enhancing diabetes treatment by targeted nucleic acid and drug delivery using cell-penetrating peptides, peptide nucleic acids, and receptor targeting. Frontiers in Pharmacology 2026, 17. doi:10.3389/fphar.2026.1867532
  • Nassar, E.; Donthoju, A.; Hasan, M.; Brik, A. Chemical Synthesis of Mirror-Image Proteins Reveals Chirality-Dependent Cellular Uptake Mediated by a Cell-Penetrating Peptide. Journal of the American Chemical Society 2026. doi:10.1021/jacs.6c03792
  • Nikhar, S.; Jahan, A.; Mahato, T.; Giri, A. S. Peptide and Antibody Functionalized Nanoparticles: Active Targeting Strategies for Next-Generation Contrast Agents and Drug Delivery Systems. ACS Applied Nano Materials 2026, 9, 10448–10477. doi:10.1021/acsanm.5c05449
  • Adam, H.; Abdollahi, S.; Al Musaimi, O. Peptide-Based Delivery Systems: Selected Insights into Cell-Penetrating Peptides. ACS chemical neuroscience 2026. doi:10.1021/acschemneuro.6c00266
  • Chiueh, V. C.; Lee, L. L.; Tau, S.; Luu, M.; Park, J. H.; Lee, T. Eye Drop Development of Anti-VEGF Therapeutics by Ocular Penetrating Carrier to the Posterior Region of the Eye. Translational vision science & technology 2026, 15, 7. doi:10.1167/tvst.15.6.7
  • Rauch-Wirth, L.; Roche, J. L.; Kaygisiz, K.; Kuhn, A.; Jeon, N.; Stifel, U.; Zech, F.; Fischer-Posovszky, P.; Weil, T.; Read, C.; Münch, J. Structural morphology of peptide nanofibrils dictates viral capture and cellular uptake in gene therapy applications. Nano Today 2026, 69, 103015. doi:10.1016/j.nantod.2026.103015
  • Pašalić, L.; Maleš, P.; Pem, B.; Jakas, A.; Wallner, J.; Kuvek, T.; Grundschober, N.; Galicia-Andrés, E.; Petrov, D.; Bakarić, D. Interaction of tryptophan-based peptides with mixed lipid bilayers modulates bilayers' hydrophobic region in an anionic lipid-dependent manner. Chemistry and physics of lipids 2026, 278-279, 105591. doi:10.1016/j.chemphyslip.2026.105591
  • Vanmeerhaeghe, B.; Remaut, K.; Roels, D.; De Smedt, S. C.; Sauvage, F. Non-viral strategies for transfection of the corneal endothelium. Journal of controlled release : official journal of the Controlled Release Society 2026, 395, 115025. doi:10.1016/j.jconrel.2026.115025
  • Pizarro, B. S.; Reinhardt, T. G.; Semenske, J. A.; Ji, Z.; Jacobs, C. O.; Zeno, W. Amphiphilic Peptide Fusion Promotes Endocytic Uptake of Nanodiscs. 2026. doi:10.64898/2026.05.08.723726
  • Sultana, Z.; Ahamed, A.; Hoda, M.; Ali, S.; Hoque, M. Prospects and challenges in intracellular delivery of therapeutic proteins. Pharmacological reports : PR 2026, 78, 679–706. doi:10.1007/s43440-026-00855-5
  • Jang, Y. E.; Kwon, M.; Kwon, C. W.; Kim, S. G.; Hwang, J. S.; George, N. P.; Paik, S. R.; Misra, S.; Basith, S.; Sheen, S. S.; Lee, G. Integrative Peptide Drug Development: Chemical Engineering, AI-Driven Design, and Cell-Penetrating Peptides. Pharmaceutics 2026, 18, 537. doi:10.3390/pharmaceutics18050537
  • Gunning, V.; Batchelor, M.; Alexander, K. K.; Walko, M.; Dill, T. C.; Burgess, S. G.; Royle, S. J.; Kennedy, E. J.; Bayliss, R. Mechanistic design of cell-penetrating disruptors for phospho-dependent TACC3-CHC interaction. Structure (London, England : 1993) 2026, 34, 915–931.e12. doi:10.1016/j.str.2026.04.001
  • Obara, C.; Kato, N. Cellular Responses to the Subtle Perturbation of Lipid Ordering in the Plasma Membrane Induced by Intracellular Delivery Agents. The journal of physical chemistry. B 2026, 130, 4780–4791. doi:10.1021/acs.jpcb.6c00595
  • Yamahata, I.; Shimamura, T.; Hayashi, S. Closed-Loop Multi-Objective Optimization for Receptor-Selective Cell-Penetrating Peptide Design. openRxiv 2026. doi:10.64898/2026.04.16.718169

Patents

  • NIJJAR TARLOCHAN S; TAM STEPHEN JED. METHODS, COMPOSITIONS, AND KITS INCLUDING CELL-PENETRATING AGENTS. WO 2025059491 A2, March 20, 2025.
  • NIJJAR TARLOCHAN S; TAM STEPHEN JED. CELL PENETRATING AGENTS AND USES THEREOF. WO 2025059515 A2, March 20, 2025.
  • NIJJAR TARLOCHAN S; TAM STEPHEN JED. CELL PENETRATING AGENTS AND USES THEREOF. WO 2025059487 A2, March 20, 2025.
  • SAITAKIS MICHAEL; AMIGORENA SEBASTIAN; FUENTEALBA JAIME RODRIGO; LOPEZ COBO SHEILA; ALCANTARA MARION; TSALKITZI KYRIAKI. COMPOSITIONS AND METHODS FOR TREATING A REFRACTORY OR RELAPSED CANCER OR A CHRONIC INFECTIOUS DISEASE. WO 2023222928 A2, Nov 23, 2023.
  • BLACKWOOD ERIK; GLEMBOTSKI CHRISTOPHER. SGK1 INHIBITORY COMPOSITIONS AND METHODS. WO 2023114714 A1, June 22, 2023.
Other Beilstein-Institut Open Science Activities