Key for crossing the BBB with nanoparticles: the rational design

Sonia M. Lombardo, Marc Schneider, Akif E. Türeli and Nazende Günday Türeli
Beilstein J. Nanotechnol. 2020, 11, 866–883. https://doi.org/10.3762/bjnano.11.72

Cite the Following Article

Key for crossing the BBB with nanoparticles: the rational design
Sonia M. Lombardo, Marc Schneider, Akif E. Türeli and Nazende Günday Türeli
Beilstein J. Nanotechnol. 2020, 11, 866–883. https://doi.org/10.3762/bjnano.11.72

How to Cite

Lombardo, S. M.; Schneider, M.; Türeli, A. E.; Günday Türeli, N. Beilstein J. Nanotechnol. 2020, 11, 866–883. doi:10.3762/bjnano.11.72

Download Citation

Citation data can be downloaded as file using the "Download" button or used for copy/paste from the text window below.
Citation data in RIS format can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Zotero.

Presentation Graphic

Picture with graphical abstract, title and authors for social media postings and presentations.
Format: PNG Size: 651.9 KB Download

Citations to This Article

Up to 20 of the most recent references are displayed here.

Scholarly Works

  • Ajayi, E. D.; Elazazy, M.; Abouzid, K.; Ali, H. I. Breaking barriers: Medicinal chemistry strategies and advanced in-silico approaches for overcoming the BBB and enhancing CNS penetration. European journal of medicinal chemistry 2025, 301, 118219. doi:10.1016/j.ejmech.2025.118219
  • Pajarskienė, J.; Vailionytė, A.; Uogintė, I.; Byčenkienė, S.; Pociūtė, A.; Bagdonas, E.; Aldonytė, R. Modulative effects of carbon black and polyethylene micro-nanoplastic particles on blood-brain barrier model invitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025, 206, 115762. doi:10.1016/j.fct.2025.115762
  • García-Domínguez, M. Interplay Between Aging and Glial Cell Dysfunction: Implications for CNS Health. Life (Basel, Switzerland) 2025, 15, 1498. doi:10.3390/life15101498
  • Ali-Jerman, H.; Somani, S.; Al-Quraishi, Z.; Maeyouf, K.; Merkler, M.; Gerasimou, S.; Tate, R. J.; Sakata, S.; Mullin, M.; Irving, C.; Anderson, G. J.; Bame, J. R.; MacKenzie, G.; McNeill, G.; Dufès, C. Intravenous Delivery of Angiopep-Functionalized Polypropylenimine Dendriplex Enhances Gene Expression in the Brain. International journal of nanomedicine 2025, 20, 11569–11591. doi:10.2147/ijn.s510487
  • Nájera-Maldonado, L.; Parra-González, M.; Peralta-Cuevas, E.; Gutierrez-Onofre, A. J.; Garcia-Atutxa, I.; Villanueva-Flores, F. Cracking the Blood-Brain Barrier Code: Rational Nanomaterial Design for Next-Generation Neurological Therapies. Pharmaceutics 2025, 17, 1169. doi:10.3390/pharmaceutics17091169
  • Rajput, S.; Malviya, R.; Sridhar, S. B.; Wadhwa, T.; Shareef, J.; Rana, A. Advanced miRNA-nanoparticle strategies for brain cancer treatment: Bypass the blood-brain barrier for efficient treatment. Nano-Structures & Nano-Objects 2025, 43, 101516. doi:10.1016/j.nanoso.2025.101516
  • Cakir, N.; Altas, B. O.; Kalaycioglu, G. D.; Mustafaoglu, N.; Aydogan, N. Development and characterization of DHA-integrated nanostructured lipid carrier formulations for enhanced cellular binding and uptake. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2025, 720, 137122. doi:10.1016/j.colsurfa.2025.137122
  • Chetia, M. P.; Ashraf, G. J.; Sahu, R.; Nandi, G.; Karunakaran, G.; Paul, P.; Dua, T. K. Rosemary (Rosmarinus officinalis L.) essential oil: A review of extraction technologies, and biological activities. Next Research 2025, 2, 100545. doi:10.1016/j.nexres.2025.100545
  • Zoba, A. N.; Tringides, C. M. Material considerations for delivering therapeutics across the blood–brain barrier. APL Materials 2025, 13. doi:10.1063/5.0284305
  • Senanayake, D.; Yapa, P.; Dabare, S.; Munaweera, I. Precision targeting of the CNS: recent progress in brain-directed nanodrug delivery. RSC advances 2025, 15, 25910–25928. doi:10.1039/d5ra03578c
  • Polshettiwar, S.; Khuspe, P.; Gholap, A.; Aldar, P.; Godbole, M. doi:10.1002/9781394287345.ch13
  • Shmool, T. A.; Martin, L. K.; Jirkas, A.; Morse, S. V.; Contini, C.; Elani, Y.; Hallett, J. P. Design Principles for Engineering Ionic Liquid-Gold Nanoparticles for Therapeutic Delivery to the Brain. ACS nano 2025, 19, 24806–24816. doi:10.1021/acsnano.5c02375
  • Tiwari, P.; Prajapati, S.; Dixit, V.; Raza, M. A.; Ajazuddin; Gupta, S. K.; Sharma, M. Recent advancements in nanoparticle drug delivery systems to cure neurological disorders via the nasal route. Neurología Argentina 2025, 17, 143–152. doi:10.1016/j.neuarg.2025.05.003
  • Kumbhar, P. S.; Kolekar, K. A.; Vishwas, S.; Kamble, V.; Bashir, B.; Patil, K. S.; Bhagwat, D.; Gupta, G.; Prasher, P.; Singh, M.; Singh, S. K.; Disouza, J.; Patravale, V. B. Plant-based flavonoids and their nanoparticles: Latest arsenal against Alzheimer's disease. Drug delivery and translational research 2025. doi:10.1007/s13346-025-01906-9
  • Parashar, B.; Malviya, R. Industrial Perspective of Minimally Invasive Drug Delivery System. Transdermal Applications of Minimally Invasive Drug Delivery Systems; Springer Nature Singapore, 2025; pp 259–288. doi:10.1007/978-981-96-6275-3_12
  • Sanadgol, N.; Abedi, M.; Hashemzaei, M.; Kamran, Z.; Khalseh, R.; Beyer, C.; Voelz, C. Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges. Journal of nanobiotechnology 2025, 23, 453. doi:10.1186/s12951-025-03528-2
  • Sharma, P.; Sharma, T.; Bashir, B.; Andotra, N.; Awasthi, A.; Patel, P.; Subramaniyan, V.; Chellappan, D. K.; Gupta, G.; Vishwas, S.; Singh, S. K. Role of Galangin for the Treatment of Alzheimer's Disease: Journey So Far and Road Ahead. Current nutrition reports 2025, 14, 80. doi:10.1007/s13668-025-00669-6
  • Ali, S. H.; Ali, H.; Shafi, M.; Malik, A. Breaking barriers: exploring blood-brain barrier crossing mechanisms with nanomedicine for effective glioma treatment. 3 Biotech 2025, 15, 213. doi:10.1007/s13205-025-04378-3
  • Dargude, S.; Chabukswar, A.; Jagdale, S. Breaking the brain barrier: Hybrid nanoparticle-enabled delivery for next-gen neurotherapeutics. Hybrid Advances 2025, 11, 100513. doi:10.1016/j.hybadv.2025.100513
  • Singh, K.; Gupta, J. K.; Lakhchora, G.; Jain, D.; Bhatt, A.; Sharma, M. C.; Chaitanya, M.; Tabish, M. Advance Nanotechnology-Based Drug Delivery Systems for Alzheimer's Disease: Advancements and Future Perspectives. Current Alzheimer research 2025, 22, 327–343. doi:10.2174/0115672050380959250530112247

Patents

  • WU BIN; BOYLAN NICHOLAS; WANG ZIMENG; XU JIENI. NOVEL DRUG DELIVERY COMPOSITION AND PROCESS FOR BLOOD-BRAIN BARRIER CROSSING. US 20220175689 A1, June 9, 2022.
Other Beilstein-Institut Open Science Activities