Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• biological models. Determining the appropriate dosage is another crucial factor as therapeutic performance is influenced by drug loading capacity, drug release kinetics, and loading efficiency. Careful optimisation of these parameters is required to achieve effective drug delivery while minimising harm to

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• an increased molar fraction from 1% to 5% [32]. In primary cortical neurons treated with 50 nmol antisense oligonucleotide for 24 h, LNPs with 1 mol % PEG achieved up to 80% mRNA knockdown. In contrast, LNPs with 3% and 5% PEG did not reach 50% knockdown even at the highest dosage. This pattern held

• [66]. Moderna’s mRNA-1273 vaccine contains approximately 117 μg of PEG lipids in each standard adult injection dosage and significantly increased anti-PEG immunoglobulin G (IgG) and immunoglobulin M (IgM) titers by about 13-fold and 68-fold, respectively. In contrast, Pfizer-BioNTech's BNT162b2

• vaccine, with a lower amount of PEG lipid at approximately 50 μg per injection, induced relatively modest increases in anti-PEG IgG and IgM titers at approximately 1.8-fold and 2.6-fold. These findings further demonstrated the immunogenic effect of PEG lipids, particularly at higher dosage levels, even

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

Dendrimer-modified carbon nanotubes for the removal and recovery of heavy metal ions from water

• Thao Quynh Ngan Tran,
• Huu Trung Nguyen,
• Subodh Kumar and
• Xuan Thang Cao

Beilstein J. Nanotechnol. 2025, 16, 1522–1532, doi:10.3762/bjnano.16.107

• of CNTs, CNTs-MA, CNTs-G0, CNTs-G1, CNTs-G2, CNTs-G3, and CNTs-G5; and (d) TGA curves of CNTs, CNTs-G0, CNTs-G1, CNTs-G2, CNTs-G3, and CNTs-G5. SEM images of (a) CNTs, (b) CNTs-G1, (c) CNTs-G3, and (d) CNTs-G5. Effect of (a, b) adsorbents dosage, (c) solution pH, and (d) contact time on the removal

Synthesis and antibacterial properties of nanosilver-modified cellulose triacetate membranes for seawater desalination

• Lei Wang,
• Shizhe Li,
• Kexin Xu,
• Wenjun Li,
• Ying Li and
• Gang Liu

Beilstein J. Nanotechnol. 2025, 16, 1380–1391, doi:10.3762/bjnano.16.100

• activity of Ag nanoparticles on the surface of the Ag@PCTA film. It is evident despite a decrease in nano Ag dosage from 0.05 mol·L−1 to 0.02 mol·L−1 (from III to IV in Figure 6), the size of the inhibitory ring remains almost unchanged, highlighting the robust antibacterial performance of the Ag@PCTA

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• , external stimuli (e.g., temperature, light, or ultrasound (US)) [172] can also be used. The release of drugs from liposomes stimulated by external stimuli offers greater precision in terms of timing and location of release as well as better regulation of drug delivery and dosage [172][173]. Figure 4 shows

Synthesis of a multicomponent cellulose-based adsorbent for tetracycline removal from aquaculture water

• Uyen Bao Tran,
• Ngoc Thanh Vo-Tran,
• Khai The Truong,
• Dat Anh Nguyen,
• Quang Nhat Tran,
• Huu-Quang Nguyen,
• Jaebeom Lee and
• Hai Son Truong-Lam

Beilstein J. Nanotechnol. 2025, 16, 728–739, doi:10.3762/bjnano.16.56

• , hydrogen bonding, and CH–π interactions, with surface complexation between Ca2+ and TCs being dominant. Batch adsorption experiments conducted to examine the factors influencing adsorption capacity revealed that PGC achieved up to 70% TC removal efficiency at an adsorbent dosage of 40 mg and an initial TC

• characteristics and morphology of the synthesized adsorbent. Additionally, the study examines the adsorption mechanism of TC on the material’s surface and evaluates the effects of pH value, adsorbent dosage, and matrix composition. As a biodegradable and easily recoverable material derived from natural cellulose

• dosage An adsorption experiment was performed using 10 different adsorbent dosages at an initial TC concentration of 60 mg·L−1 and pH 6–7. Figure 4b presents the effect of adsorbent dosage on the TC adsorption capacity and efficiency of PGC. Notably, as the adsorbent dosage increases, TC adsorption

Aprepitant-loaded solid lipid nanoparticles: a novel approach to enhance oral bioavailability

• Mazhar Hussain,
• Muhammad Farooq,
• Muhammad Asad Saeed,
• Muhammad Ijaz,
• Sherjeel Adnan,
• Zeeshan Masood,
• Muhammad Waqas,
• Wafa Ishaq and
• Nabeela Ameer

Beilstein J. Nanotechnol. 2025, 16, 652–663, doi:10.3762/bjnano.16.50

• nausea and/or vomiting in those who receive chemotherapy. Factors that affect the incidence and severity of CINV in patients are schedule, dosage, route of administration of chemotherapy, age, sex, and history of alcohol use [4]. CINV are treated by commonly used agents such as dopamine antagonists, 5HT3

• , or applying cyclodextrin complexation or salt formation. However, these techniques depend on the physicochemical features of the drug in each case. SLNs are the easiest and most suitable scalable of the above approaches for developing stable commercially viable dosage forms [11]. Various methods such

• than the poloxamer 407-based formulations in phosphate-buffered saline (pH 7.4) and 0.1 N HCl (pH 1.2). The optimal SLN formulation APT-CD-NP4 is a promising tool for oral sustained-release dosage in order to improve the bioavailability of the BCS class-IV drug APT. Solubility analysis of APT and APT

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• both situations, the effectiveness of the drug formulation depends on several factors such as gastric residence time, gastric emptying, release rate of the drug from the dosage form, and the therapeutic agent reaching the site of action or absorption. Conventional drug delivery systems may not be

Emerging strategies in the sustainable removal of antibiotics using semiconductor-based photocatalysts

• Yunus Ahmed,
• Keya Rani Dutta,
• Parul Akhtar,
• Md. Arif Hossen,
• Md. Jahangir Alam,
• Obaid A. Alharbi,
• Hamad AlMohamadi and
• Abdul Wahab Mohammad

Beilstein J. Nanotechnol. 2025, 16, 264–285, doi:10.3762/bjnano.16.21

• that of pure TiO2 and Fe2O3 under visible light illumination (500 W halogen lamp and wavelengths above 400 nm) [72]. At a dosage of 0.012 g/L of α-Fe2O3@TiO2 and pH 4.76, 98.8% of an initial CFX concentration of 20.5 mg/L was effectively removed after 103 min. The heterojunction formed between TiO2 and

• after 30 min treatment at a dosage of 500 mg/L of catalyst, at pH 4.8 and an initial TC concentration of 20 mg/L [91]. The degrading effectiveness of the photocatalysts reduced as the amount of sorbitol was increased. The improved photodegradation was possible because the catalyst prevented the

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• ]. Chemotherapy poses difficulties in accurately controlling drug deposition on the ocular surface and dosage, with frequent administrations often leading to complications such as retinal edema, vitreous hemorrhage, and ocular deformity [98][99]. Direct photothermal therapy (PTT) may induce irreversible thermal

• explanations of material size, structure, dosage, and administration methods [215]. During treatment, processes such as nanoparticle aggregation, material degradation, cellular uptake/excretion, and unintended release of adsorbents require comprehensive safety analysis. In inorganic photothermal nanomaterials

A nanocarrier containing carboxylic and histamine groups with dual action: acetylcholine hydrolysis and antidote atropine delivery

• Elina E. Mansurova,
• Andrey A. Maslennikov,
• Anna P. Lyubina,
• Alexandra D. Voloshina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Anzhela A. Mikhailova,
• Polina V. Mikshina,
• Albina Y. Ziganshina and
• Igor S. Antipin

Beilstein J. Nanotechnol. 2025, 16, 11–24, doi:10.3762/bjnano.16.2

• , vomiting, and other serious issues [1]. ACh overproduction usually results from a malfunction of the cholinesterase enzyme caused by poisoning or medication [2][3]. Drug dosage regulation can greatly lower cholinergic toxicity [4], but the risks associated with poisoning are far higher. Poisons cause

Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• adverse reactions. The toxicity of MNPs depends on various factors such as size, shape, structure, surface modification, concentration, dosage, biodistribution, bioavailability, solubility, immunogenicity, and pharmacokinetics [23][24]. Their use in some clinical applications is limited by low solubility

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• ]. These direct anatomical interactions make the olfactory region the primary target for N2B delivery and bypass the BBB [21][44]. However, some factors, such as high mucociliary clearance and short retention time, small dosage volume, and the need for a drug delivery device, limit N2B delivery (Figure 2

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• targeting and rapid clearance of PSMA-targeting AuNCs offers the potential for reducing radiation dosage and minimizing exposure to healthy tissue. Chen et al. developed renal-clearable and PSMA-targeting C’ dots for dual-modality imaging of prostate cancer [130]. These particles featured a ≈4 nm silica

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• disease, and post-traumatic stress disorder [13][14][15][16]. In general, solid dosage forms for oral administration are preferable for therapies against CNS disorders. Nevertheless, challenges persist with oral solid dosage forms, including issues of bioavailability and clinical efficacy [17]. On the

• , matrix, and microneedle systems [24][25][26]. In addition, enteric-coated solid dosage forms for oral administration have shown significant improvement in providing better absorption and targeted delivery [27][28]. In this study, due to high water solubility of DCS (Log P = −1.72) and difficulty to

• for enteric solid dosage coating and is used in this work for DCS enteric administration test. An amount of 5.66 g of Kollicoat MAE 30 DP was mixed with 0.34 g of propylene glycol for the enteric coating material, which was evenly brushed on the surface of the size 9 empty porcine hard gelatin

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• ]. The dosage of BNZ has been reported to be inadequate [21]. In children, markedly lower plasma BNZ concentrations than those previously reported in adults treated with comparable BNZ milligram per kilogram doses (possibly due to a higher clearance/bioavailability), but still retaining a high

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• anticancer drugs while mitigating the adverse effects of large dosage administration [6][7]. Additionally, it offers several advantages, such as controlled release, targeted drug delivery, and improved stability [8]. Moreover, nanoscale drug delivery systems hold great promise for specific cancer treatments

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• between F127@NP and F127-folate@NP. The IC50 of CHL for MCF-7 was 0.4 μg/mL. After 72 h of incubation, the NPs had some impact on the MCF-7 cells. At a dosage of 1.5 mg/mL, the cell viability of both F127@NP and F127-folate@NP decreased to approximately 50%. These results were below PVA@NP (75%). Similar

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• usually more susceptible to drug action than males. However, in this work, the death of females was only possible in a high concentration of the nanoformulation (100 µg/mL). Every dosage tested was also effective against young forms (esquistosomules) [60]. El-Menyawy et al. [61] used thymoquinone, a

• with chitosan nanoparticles may be a pharmacological strategy to replace PZQ or to help lower its dosage. However, the author admits in this work that no data proves the biological safety of using chitosan in a nanoformulation [63]. While on the subject, other extracts of vegetal sources were also

• (intraperitoneal and subcutaneous). Therefore, drug dosage forms with these characteristics may present compliance issues and problems with commercialization. Thus, an interesting pathway could be testing the same nanoformulations but using the oral route. After antimonials such as tartar emetic, oxamniquine was

Industrial perspectives for personalized microneedles

• Remmi Danae Baker-Sediako,
• Benjamin Richter,
• Matthias Blaicher,
• Michael Thiel and
• Martin Hermatschweiler

Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70

• Quantum X platform that commercialized maskless grayscale lithography for microoptics made via 2PP, a process called “Two-Photon Grayscale Lithography” (2GL®) [59][60]. 2GL® differs from traditional 2PP and 1PP lithography because the laser or exposure dosage in individual voxels is controlled in three

• produce tens of millions of Nanopatches per week for COVID-19 vaccination [64][65]. If companies were to personalize and optimize microneedles (including design, dosage, and vaccine composition) for COVID-19 or influenza vaccination based on ethnicities [66], those manufacturers would have to produce

ZnO-decorated SiC@C hybrids with strong electromagnetic absorption

• Liqun Duan,
• Zhiqian Yang,
• Yilu Xia,
• Xiaoqing Dai,
• Jian’an Wu and
• Minqian Sun

Beilstein J. Nanotechnol. 2023, 14, 565–573, doi:10.3762/bjnano.14.47

• that crystalline ZnO particles adhere to the surface of amorphous carbon, and the ZnO content increases as a function of a dosage of ZnNO3·6H2O. The as-prepared SiC@C-ZnO hybrids exhibit effective electromagnetic absorption, which is related to a synergy effect of different dielectric loss processes

• , which has been rarely investigated before. Herein, we describe a new strategy for preparing ternary hybrids (SiC@C-ZnO, SCZ) by growing ZnO particles on carbon surfaces derived from SiC nanowires. The influence of ZnO precursor (ZnNO3·6H2O) dosage on composition, microstructure and electromagnetic

• after filtering, washed with distilled water, and dried at 50 °C under vacuum. The final samples were obtained by calcination at 600 °C for 4 h in a tube furnace (Ar, 99.999% purity). We labeled the samples as SCZx, where x indicates x mmol dosage of ZnNO3·6H2O. Results and Discussion All SCZ samples