Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil

• Daniel T. Pereira,
• Douglas Dourado,
• Danielle T. Freire,
• Dayanne L. Porto,
• Cícero F. S. Aragão,
• Myla L. de Souza,
• Guilherme R. S. de Araujo,
• Ana Maria Costa,
• Wógenes N. Oliveira,
• Anne Sapin-Minet,
• Éverton N. Alencar and
• Eryvaldo Sócrates T. Egito

Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146

• ® and additional licensed figures. The image of the beaker was provided by Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/); The image of the GC–MS was adapted from https://commons.wikimedia.org/wiki

Rapid synthesis of highly monodisperse AgSbS₂ nanocrystals: unveiling multifaceted activities in cancer therapy, antibacterial strategies, and antioxidant defense

• Funda Ulusu,
• Adem Sarilmaz,
• Yakup Ulusu,
• Faruk Ozel and
• Mahmut Kus

Beilstein J. Nanotechnol. 2025, 16, 2105–2115, doi:10.3762/bjnano.16.145

• , chemical, or biological attributes offer novel foundational elements for the design and development of devices and systems aimed at diagnosing and treating various diseases. Hence, nanoparticles or nanomaterials can be engineered to have various useful medical functions [4]. The assessment of the

• cascade of events leads to DNA breakage, heightened expression of death receptors, and ultimately culminates in apoptosis-driven cell death [10]. Therefore, nanoparticles can be considered as a medical agent in the treatment of various diseases that can be caused by free radicals, such as cancer

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• , Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), 50670-420 Recife, PE, Brazil Department of Entomology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (FIOCRUZ), 50670-420 Recife, PE, Brazil Faculty of Medical Sciences (FCM), University of Pernambuco (UPE), 50100-130, Recife

Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength

• Shrutika Sawant,
• Anne Marie Power and
• J. Gerard Wall

Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129

• Shrutika Sawant Anne Marie Power J. Gerard Wall Microbiology, School of Biological and Chemical Sciences, University of Galway, University Rd, Galway H91 TK33, Ireland CÚRAM Research Ireland Centre for Medical Devices, University of Galway H91 TK33, Ireland Ryan Institute, School of Natural

On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review

• Lorena Pinheiro Vasconcelos Silva,
• Joice Catiane Soares Martins,
• Israel Luís Carvalho Diniz,
• Júlio Abreu Miranda,
• Danilo Rodrigues de Souza,
• Éverton do Nascimento Alencar,
• Moan Jéfter Fernandes Costa and
• Pedro Henrique Sette-de-Souza

Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128

• country is home to a large number of public and private universities, research institutes, and government-funded agencies (e.g., “Council of Scientific & Industrial Research” (CSIR), “Indian Council of Medical Research” (ICMR), and “Department of Biotechnology” (DBT)), which actively promote low-cost, eco

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• considered statistically significant for p < 0.05. Schematic illustration of PHYT-NE preparation: (a) size distribution of nanodroplets (b) and morphological aspects of blank-NE (c) and PHYT-NE (d). Figure 1a) is adapted from Servier Medical Art (https://smart.servier.com/), licensed under CC BY 4.0 (https

• nanoemulsion (per 10 g). Supporting Information Supporting Information File 14: Additional figure. Acknowledgements The Graphical Abstract was created from elements from the Servier Medical Art collection (https://smart.servier.com/), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• Yang Fei Hui Xu Chunwei Zhang Jingjing Wang Yong Jin School of Pharmaceutical Sciences, Anhui Medical University, Hefei, Anhui, China 10.3762/bjnano.16.121 Abstract Esophageal cancer (EC) is a common malignant tumor of the digestive tract with poor prognosis and high mortality. The early

• against esophageal cancer. Funding This work was supported by the Pharmaceutical Summit Discipline Fund of Anhui Medical University (2023xkjd04). Conflict of Interest The authors declare no conflict of interest.

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• within the emulsion [74]. An important quality parameter of LO is the free fatty acid (FFA) content, determined by the AV. A lower AV signifies a reduced FFA content, indicating higher oil quality and enhanced bioactive functionality, making it well-suited for medical applications. The AV measured for LO

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• dose of its active ingredients [96]. These characteristics have made nanoparticles widely used in medicines, medical applications, and the food industry, as they provide increased shelf life, improved drug delivery, and enhanced therapeutic efficacy [97]. Various methods, such as chemical reduction

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• a Brazilian scorpion species with great medical significance [2][5], responsible for the highest number of accidents and also the most severe ones [6][7]. Scorpion toxins represent a vast collection (≈100,000) of pharmacologically relevant peptide toxins that have provided an important foundation

Transient electronics for sustainability: Emerging technologies and future directions

• Jae-Young Bae,
• Myung-Kyun Choi and
• Seung-Kyun Kang

Beilstein J. Nanotechnol. 2025, 16, 1545–1556, doi:10.3762/bjnano.16.109

• discourse, it has long been recognized in several application domains. For instance, biodegradable polymer-based materials have been extensively explored as environmentally benign alternatives that do not leave persistent residues [4]. Similarly, in the realm of implantable medical devices, efforts have

• persistence. One of the most compelling applications of transient electronics is in minimally invasive implantable medical devices designed for postoperative care and rehabilitative medicine. During the immediate postoperative recovery period, clinical needs are typically limited to short-term monitoring or

• materials exhibit strong potential for the use in implantable medical devices. For instance, Ge nanomembranes have been employed in fully biodegradable strain and temperature sensors, demonstrating proven biocompatibility and gas-free dissolution. In addition, IGZO has been utilized to fabricate transient

Nanomaterials for biomedical applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Filippo Pierini,
• Seda Kizilel and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 1499–1503, doi:10.3762/bjnano.16.105

• diagnostics and medical imaging. Using these materials, physicians diagnose diseases earlier and more accurately than before [4]. In tissue engineering, nanofibers are being used to develop scaffolds to promote the proliferation of cells. These scaffolds aid patients suffering from chronic wounds as they

• color upon detecting the virus. Their capability to attach to specific antibodies or DNA strands makes them perfect for detecting even faint traces of disease [18]. Moreover, magnetic nanoparticles specially made from iron oxide are also being used in medical imaging. They are usually employed as

• used in the future for tissue recovery, which was previously thought to be beyond repair [31]. In addition to diagnosis and tissue regeneration, nanomaterials can create new treatment methods and enhance the design and performance of medical implants. An area that is getting a lot of attention is

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

Parylene-coated platinum nanowire electrodes for biomolecular sensing applications

• Chao Liu,
• Peker Milas,
• Michael G. Spencer and
• Birol Ozturk

Beilstein J. Nanotechnol. 2025, 16, 1392–1400, doi:10.3762/bjnano.16.101

• ]. After 100 years of evolution, electrodes have become ubiquitous across numerous industries including medical diagnostics, food safety, agricultural and environmental monitoring, bioprocess management, and more [2]. Despite the differences in design and function, all electrodes share similar requirements

Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems

• Alejandro Llamedo,
• Marina Cano,
• Raquel G. Soengas and
• Francisco J. García-Alonso

Beilstein J. Nanotechnol. 2025, 16, 1350–1366, doi:10.3762/bjnano.16.98

• during storage [83][84]. Their surfaces can be modified for targeted delivery, improving the bioavailability of therapeutic agents and allowing for their use in a variety of medical applications. Despite these advantages, challenges such as particle aggregation and potential toxicity continue to persist

Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• Alireza Ghasempour Mohammad Amin Tokallou Mohammad Reza Naderi Allaf Mohsen Moradi Hamideh Dehghan Mahsa Sedighi Mohammad-Ali Shahbazi Fahimeh Lavi Arab Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Immunology Research Center, Mashhad University of Medical

• Sciences, Mashhad, Iran Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran Department of Biomaterials and

• Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 10.3762/bjnano.16.97 Abstract

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• have several medical applications. However, little is known about its pharmacological activity. Therefore, this study aimed to develop and evaluate the anti-inflammatory activity of a nanoemulsion loaded with the oil extracted from the pulp of the fruit of Acrocomia aculeata. Griffin’s method

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• Imran Shair Mohammad Gizem Kursunluoglu Anup Kumar Patel Hafiz Muhammad Ishaq Cansu Umran Tunc Dilek Kanarya Mubashar Rehman Omer Aydin Yin Lifang Department of Radiology, City of Hope National Medical Center, 1500 East Duarte Rd., Duarte, California 91010, USA Nanothera Lab, Drug Application and

• vaccines and improving their immunogenicity [112]. The presence of viral nucleic acids has been a key concern in medical applications, which limits the use of viruses in living organisms. Virus-like particles are multimeric nanoparticles consisting of viral proteins but lack viral genetic material. Thus

Functional bio-packaging enhanced with nanocellulose from rice straw and cinnamon essential oil Pickering emulsion for fruit preservation

• Tuyen B. Ly,
• Duong D. T. Nguyen,
• Hieu D. Nguyen,
• Yen T. H. Nguyen,
• Bup T. A. Bui,
• Kien A. Le and
• Phung K. Le

Beilstein J. Nanotechnol. 2025, 16, 1234–1245, doi:10.3762/bjnano.16.91

• microbial access [7]. PVA also exhibits superior biocompatibility as evidenced by its high safety threshold (LD50 of 15–20 g·kg−1), low systemic absorption, absence of mutagenic effects, and established medical applications, making it a reliable choice for biopackaging without concerns of harmful

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• have emerged as promising alternatives for various medical purposes, including skin [7], nasal [4], and eye [8] applications. The evolution of ocular contact lenses, for example, has benefited from the development of hydrogels [9][10]. Hydrogels can be described as cross-linked polymeric networks

• , and obtaining processes are unlocking unprecedented properties in hydrogels and nanogels, paving the way for innovative medical approaches. Structure of hydrogels and nanogels of cross-linked polymers. Cross-linking is a technique for forming hydrogels, a process in which polymer chains are joined

Electronic and optical properties of chloropicrin adsorbed ZnS nanotubes: first principle analysis

• Prakash Yadav,
• Boddepalli SanthiBhushan and
• Anurag Srivastava

Beilstein J. Nanotechnol. 2025, 16, 1184–1196, doi:10.3762/bjnano.16.87

• and selectivity for specific gases [36]. These attributes make ZnS NTs highly attractive for diverse applications, including detecting volatile organic compounds, choking and pulmonary toxicants, medical diagnostics, and developing portable and wearable gas sensing devices [18][37][38][39][40][41][42

Mechanical stability of individual bacterial cells under different osmotic pressure conditions: a nanoindentation study of Pseudomonas aeruginosa

• Lizeth García-Torres,
• Idania De Alba Montero,
• Eleazar Samuel Kolosovas-Machuca,
• Facundo Ruiz,
• Sumati Bhatia,
• Jose Luis Cuellar Camacho and
• Jaime Ruiz-García

Beilstein J. Nanotechnol. 2025, 16, 1171–1183, doi:10.3762/bjnano.16.86

• medical devices [1][2][3][4][5]. Although PA is part of the normal microbiota of the skin and mucous membranes of many healthy individuals, it can cause serious opportunistic infections in the respiratory and urinary tracts and during wound healing in people with weakened immune systems or in hospitalized

Fabrication of metal complex phthalocyanine and porphyrin nanoparticle aqueous colloids by pulsed laser fragmentation in liquid and their potential application to a photosensitizer for photodynamic therapy

• Taisei Himeda,
• Risako Kunitomi,
• Ryosuke Nabeya,
• Tamotsu Zako and
• Tsuyoshi Asahi

Beilstein J. Nanotechnol. 2025, 16, 1088–1096, doi:10.3762/bjnano.16.80

• against cancer cells was reported. However, conventional methods of producing nanoparticle colloids require organic solvents and excessive amounts of organic adjuvants, which may have other implications for research in pharmacological, photochemical, and medical applications, and also may interfere with

Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts

• Sevin Adiguzel,
• Nilay Cicek,
• Zehra Cobandede,
• Feray B. Misirlioglu,
• Hulya Yilmaz and
• Mustafa Culha

Beilstein J. Nanotechnol. 2025, 16, 1068–1081, doi:10.3762/bjnano.16.78

• the broader implications of hBNs in applications such as wireless tissue stimulation and noninvasive therapeutic strategies, positioning them as promising candidates in advanced medical treatments aimed at enhancing bone regeneration and healing. In conclusion, our groundbreaking findings demonstrate

• regeneration and bone healing, potentially ushering in a new era of medical advancements. PRFM amplitude and phase images of hBNs and BaTiO3. Viability of HOb cells treated with hBNs, hBNs+US, BaTiO3, and BaTiO3+US for (a) 24 h and (b) 48 h. Statistically significant change compared to the control group were

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• ][212], tissue engineering [213][214][215][216][217], and medical applications [218][219][220][221][222]. It seems reasonable to posit that nanoarchitectonics will make a significant contribution to the field of soft materials science. This is due to the fact that the methods employed in

• . Consequently, rod-shaped gold nanoparticles have been the subject of considerable interest with regard to their potential use in optical antennas, sensitive biosensors, and medical applications. This is due to their strong plasmonic absorption in the visible–near infrared region, which is caused by electronic

• nanoarchitectonics also makes a contribution to the field of medicine. For instance, patients with diabetic bone defects require novel and efficacious medical implant material strategies to enhance their prognosis. It is imperative to minimize the risk of implant failure due to excessive oxidative stress and the