Continuous parallel ESI-MS analysis of reactions carried out in a bespoke 3D printed device

• Jennifer S. Mathieson,
• Mali H. Rosnes,
• Victor Sans,
• Philip J. Kitson and
• Leroy Cronin

Beilstein J. Nanotechnol. 2013, 4, 285–291, doi:10.3762/bjnano.4.31

• using three-dimensional (3D) printing, which can be directly linked to a high-resolution electrospray ionisation mass spectrometer (ESI-MS) for real-time, in-line observations. To highlight the potential of the setup, supramolecular coordination chemistry was carried out in the device, with the product

• parallel analysis; ESI-MS; 3D printing; reactionware; supramolecular chemistry; Introduction Flow chemistry is a growing field that can increase productivity and control, ensure reproducibility and reduce manual handling [1]. There is currently a huge interest in directly interfacing milli- and

• /outcome. Traditionally, when interfacing flow devices with ESI-MS analysis complicated and expensive microscale fluidic devices have been required. Herein, we present an approach interfacing ESI-MS with a 3D-printed milliscale device, or tailored “reactionware” [4]. The use of 3D printing bypasses