Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

• Liga Saulite,
• Karlis Pleiko,
• Ineta Popena,
• Dominyka Dapkute,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

• drug efflux transporter P-glycoprotein, which ensures rapid excretion of toxic substances from MSCs. Thus, MSCs are an excellent vector for low cytotoxicity anticancer drugs [4]. Sadhukha et al. demonstrated that nanoengineered MSCs home to A549 lung cancer in vivo and remain there for at least 3 h

• , which could be sufficient time to release drugs into the tumour. The encapsulation of NP-linked anticancer drugs could ensure metered drug release in tumours [2]. QD linkage to photosensitisers, such as chlorin e6, causes damage to MiaPaCa2 cancer cells via light-induced cytotoxicity, demonstrating a

Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery

• Gamze Varan,
• Juan M. Benito,
• Carmen Ortiz Mellet and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1457–1468, doi:10.3762/bjnano.8.145

• during chemotherapy. Amphiphilic cyclodextrins are favored oligosaccharides as drug delivery systems for anticancer drugs, having the ability to spontaneously form nanoparticles without surfactant or co-solvents. In the past few years, polycationic, amphiphilic cyclodextrins were introduced as effective

• as well as other lipophilic anticancer drugs for cancer therapy. In addition, by formulating with anionic and cationic amphiphilic CDs, it will be possible to enhance anticancer activity of drugs, overcoming the problem of surfactant-induced toxicity. Finally, it can be said that polycationic

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• , facilitating chemotherapy administration to prevent recurrence of the tumor at the time of tumor tissue removal by surgical operation. Among the anticancer drugs that are used in clinics, the taxane family of drugs such as paclitaxel and docetaxel are known to be highly effective against a variety of cancer

• often cause serious side effects. Thus, the necessity of a safe and effective formulation and drug delivery approach emerges for these potent anticancer drugs from the taxane family [10][11][12][13]. Successful treatment of brain cancer is dependent on the efficient and safe delivery of chemotherapeutic

Nanoscale isoindigo-carriers: self-assembly and tunable properties

• Tatiana N. Pashirova,
• Andrei V. Bogdanov,
• Lenar I. Musin,
• Julia K. Voronina,
• Irek R. Nizameev,
• Marsil K. Kadirov,
• Vladimir F. Mironov,
• Lucia Ya. Zakharova,
• Shamil K. Latypov and
• Oleg G. Sinyashin

Beilstein J. Nanotechnol. 2017, 8, 313–324, doi:10.3762/bjnano.8.34

• toxicity as well as to minimize drug degradation and to provide a controllable drug release [51][52][53]. The modification of nanostructures with conjugated π–π fragments leads to the absorption of anticancer drugs via π–π stacking interaction and increases the drug-loading capacity of nanoscale soft

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• effects of MCNs could be due to the synergistic effects of Cs and MIF. Previous studies using other cancer cell lines and other anticancer drugs also found the anticancer effects of Cs and the synergistic interplay of CNs and anticancer drugs [35][36]. Besides, the sustained release of MIF from the CNs

Green and energy-efficient methods for the production of metallic nanoparticles

• Mitra Naghdi,
• Mehrdad Taheran,
• Satinder K. Brar,
• M. Verma,
• R. Y. Surampalli and
• J. R. Valero

Beilstein J. Nanotechnol. 2015, 6, 2354–2376, doi:10.3762/bjnano.6.243

• delivery of anticancer drugs have been demonstrated [24][25][26][27][28][29][30][31][32][33][34]. In Table 1, the application of different metallic NPs is summarized. Green Chemistry metrics Green Chemistry is gradually integrated into new scientific and industrial developments to be aligned with the

Natural and artificial binders of polyriboadenylic acid and their effect on RNA structure

• Giovanni N. Roviello,
• Domenica Musumeci,
• Valentina Roviello,
• Marina Pirtskhalava,
• Alexander Egoyan and
• Merab Mirtskhulava

Beilstein J. Nanotechnol. 2015, 6, 1338–1347, doi:10.3762/bjnano.6.138

• in the field of the development of novel anticancer drugs, we report a description of different classes of molecules characterized by their ability to interact with poly(rA). Some of them are of natural origin, as in the case of neomycin, palmatine, berberine, chelerythrine and other alkaloids and

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• study revealed that platinum-based anticancer drugs preferentially interacted with Al-doped BNNTs as compared to pristine, zigzag and armchair BNNTs [88]. Cisplatin (cis-Pt) and nedaplatin (neda-Pt) molecules were used as platinum-based anticancer drugs. An aluminum (Al) atom is substituted for a boron

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• revealed the activation of several genes downstream of EGR1 and TXNIP. Six hours after administration, CYR61, which is involved in resistance to PTX in breast cancer, became more active and continued to be influenced by EGR1. In this way, cancer cells exposed to anticancer drugs acquire resistance to the

Carbon-based smart nanomaterials in biomedicine and neuroengineering

• Antonina M. Monaco and
• Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

• anticancer drugs and preserving their activity under biological conditions [81][82][83][84]. The affinity of NDs for protein adsorption has been finally utilised to separate recombinant proteins from Escherichia coli [85], resulting not only in a radically faster process than the commonly used purification

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

• Dickson Joseph,
• Nisha Tyagi,
• Christian Geckeler and
• Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

• deaths in the modern world. Although significant advances in science and technology have given us a more comprehensive understanding of cancer, the diagnosis and treatment of cancer remain challenging. The inability of many anticancer drugs to reach the specific target sites and their common systemic

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• current standard of care is chemotherapy, which involves the use of toxic anticancer drugs, like doxorubicin (DOX), to treat cancers by inducing apoptosis. DOX has had high success rates with treating prostate cancer [2]. However, it can cause major side effects such as hair loss, nausea [2][3], and

Extracellular biosynthesis of gadolinium oxide (Gd₂O₃) nanoparticles, their biodistribution and bioconjugation with the chemically modified anticancer drug taxol

• Shadab Ali Khan,
• Sanjay Gambhir and
• Absar Ahmad

Beilstein J. Nanotechnol. 2014, 5, 249–257, doi:10.3762/bjnano.5.27

• extended the work of biosynthesis of Gd2O3 nanoparticles to bioconjugation with taxol. Bioconjugation of taxol with gold and iron oxide nanoparticles has also been reported [15][16]. Taxol is one of the most important anticancer drugs used for breast, ovarian and lung cancers [17][18]. The potent