Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

• Liga Saulite,
• Karlis Pleiko,
• Ineta Popena,
• Dominyka Dapkute,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

• origin, such as adipogenic, osteogenic and chondrogenic cells [6]. MSC-based therapies are being increasingly investigated for their promising potential in cancer diagnostics and treatment [5][7][8]. In vivo studies have demonstrated that MSCs can effectively deliver nanorattle-encapsulated doxorubicin

Hyperthermic intracavitary nanoaerosol therapy (HINAT) as an improved approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC): Technical description, experimental validation and first proof of concept

• Daniel Göhler,
• Stephan Große,
• Alexander Bellendorf,
• Thomas Albert Falkenstein,
• Mehdi Ouaissi,
• Jürgen Zieren,
• Michael Stintz and
• Urs Giger-Pabst

Beilstein J. Nanotechnol. 2017, 8, 2729–2740, doi:10.3762/bjnano.8.272

• , Erlangen, Germany) and analysed by means of suitable add-ons for planar scintigraphy (MM Oncology application) and SPECT-CT (mMR General application). Multilocal in-tissue penetration (ITP) depth analyses Multilocal in-tissue doxorubicin penetration depth analyses were performed after doxorubicin exposure

• (doxorubicin hydrochloride, Teva®, 2 mg/mL, Pharmachemie B.V., Haarlem, Netherlands) of two postmortem pig peritonea by HINAT-LAU and PIPAC-MIP. HINAT-LAU was performed with undiluted doxorubicin (drug chamber was filled with 5 mL) at a system pressure of 3 bar for 25 min that cumulated into an effective

• doxorubicin dose of 0.88 mL (i.e., 1.76 mg doxorubicin hydrochloride). PIPAC-MIP was performed with diluted doxorubicin (1 mL doxorubicin in 50 mL aqueous 0.9 wt % sodium chloride solution) at a volumetric flow rate of 30 mL/min for 100 s that led to an effective doxorubicin dose of 2.9 mL (i.e., 5.8 mg

Methionine-mediated synthesis of magnetic nanoparticles and functionalization with gold quantum dots for theranostic applications

• Arūnas Jagminas,
• Agnė Mikalauskaitė,
• Vitalijus Karabanovas and
• Jūrate Vaičiūnienė

Beilstein J. Nanotechnol. 2017, 8, 1734–1741, doi:10.3762/bjnano.8.174

• conjugated with targeting and chemotherapy agents, such as cancer stem cell-related antibodies and the anticancer drug doxorubicin, for early detection and improved treatment. In order to verify our findings, high-resolution transmission electron microscopy (HRTEM), atomic force microscopy (AFM), FTIR

A nanocomplex of C₆₀ fullerene with cisplatin: design, characterization and toxicity

• Svitlana Prylutska,
• Svitlana Politenkova,
• Kateryna Afanasieva,
• Volodymyr Korolovych,
• Kateryna Bogutska,
• Andriy Sivolob,
• Larysa Skivka,
• Maxim Evstigneev,
• Viktor Kostjukov,
• Yuriy Prylutskyy and
• Uwe Ritter

Beilstein J. Nanotechnol. 2017, 8, 1494–1501, doi:10.3762/bjnano.8.149

• molecules with drugs is currently considered a perspective biomedical strategy. The formation of a stable non-covalent nanocomplex of С60 fullerene with doxorubicin (C60+Dox) in aqueous solution was confirmed theoretically and experimentally [23][34][36]. The antitumor action of the C60+Dox nanocomplex was

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• studied for targeting and delivery of chemotherapeutic drugs for glioma treatment. Fang et al. prepared core–shell nanocapsules for co-delivery of the hydrophilic drug doxorubicin, and the hydrophobic drug curcumin. Their results showed that the synergistic cytotoxic effect on RG2 glioma cells was

Dispersion of single-wall carbon nanotubes with supramolecular Congo red – properties of the complexes and mechanism of the interaction

• Anna Jagusiak,
• Barbara Piekarska,
• Tomasz Pańczyk,
• Małgorzata Jemioła-Rzemińska,
• Elżbieta Bielańska,
• Barbara Stopa,
• Grzegorz Zemanek,
• Janina Rybarska,
• Irena Roterman and
• Leszek Konieczny

Beilstein J. Nanotechnol. 2017, 8, 636–648, doi:10.3762/bjnano.8.68

• , antigen-bound antibodies, cell-surface receptors) [29][34][35]. Congo red supramolecular assemblies can incorporate (through intercalation) other molecules – especially those containing planar, aromatic rings – e.g., doxorubicin, rhodamine B, other bis-azo dyes [36][37][38]. Thus CR could play a role of a

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• mechanisms proposed to explain the cellular uptake of CNTs including the passive diffusion in a non-invasive manner (tiny nanoneedle mechanism) [18]. Carbon nanotubes have been successfully used to transport different types of anticancer agents including camptothecin, doxorubicin and daunorubicin [19]. The

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• trials investigating nano versus non-nano drugs. These include facilitating comparisons between clinical trials testing nano and non-nano drug formulations involving the same active ingredient (e.g., Doxil = pegylated liposome [nano] encapsulated doxorubicin compared to Adriamycin = doxorubicin). In

Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy

• Shanka Walia and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2015, 6, 546–558, doi:10.3762/bjnano.6.57

• doxorubicin-loaded silica-encapsulated manganese oxide NPs. The TEM images showed that elemental Mn was equally distributed in the whole silica matrix. The in vitro and in vivo studies suggested that these nanocomposites can be used as a vehicle for pH-responsive intracellular release of doxorubicin. 2.5 Iron

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• in the presence and absence of a magnetic field and higher cell-associated uptake was found in the presence of a magnetic field. Then, the composites were loaded with doxorubicin (dox) to investigate the viability of LNCaP prostate cancer cells in the magnetic field. It was found that dox-loaded BNNT

• –NaGdF4:Eu composites had higher toxicity in the presence of a magnetic field due to increased cellular uptake of the composites and thus increased doxorubicin delivery. It can be said that the BNNT–NaGdF4:Eu composites increase the chemotherapy efficiency by the use of an external magnetic field [84

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• efficacy of cancer treatments as stand-alone therapies and in combination with standard chemotherapeutic treatment regimens. The current standard of care for metastatic cancer, doxorubicin (DOX), is presented with challenges, namely toxicity due to a lack of specificity and targeted delivery. Nano-enabled

• ; doxorubicin; nanodiamond; prostate cancer; targeted drug delivery; Introduction Prostate cancer is the most frequently diagnosed malignancy in men [1]. Typically the disease is slow growing, but in some cases it progresses to an aggressively metastatic state. When prostate cancer becomes metastatic, the

• current standard of care is chemotherapy, which involves the use of toxic anticancer drugs, like doxorubicin (DOX), to treat cancers by inducing apoptosis. DOX has had high success rates with treating prostate cancer [2]. However, it can cause major side effects such as hair loss, nausea [2][3], and

In vitro toxicity and bioimaging studies of gold nanorods formulations coated with biofunctional thiol-PEG molecules and Pluronic block copolymers

• Tianxun Gong,
• Douglas Goh,
• Malini Olivo and
• Ken-Tye Yong

Beilstein J. Nanotechnol. 2014, 5, 546–553, doi:10.3762/bjnano.5.64

• or antigens to be linked to their surface for targeted delivery and imaging [16][17]. More importantly, one is not able to use CTAB-coated AuNRs as a carrier for drug delivery of water insoluble anti-cancer agents (e.g., doxorubicin, paclitaxel) to the cancerous area since their surface is