Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation

• Michał Bartkowski,
• Francesco Calzaferri and
• Silvia Giordani

Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144

• tend to evade renal filtration due to the formation of a protein corona that effectively increases their hydrodynamic size [38]. Beyond renal clearance, particle size also critically influences toxicity, metabolic fate, tumour targeting, protein interactions, and hepatic processing. Additional

• . Depending on the intended route of delivery and application, this may involve cytotoxicity assays to assess effects on cell viability and metabolism, and hemocompatibility assays to evaluate interactions with blood components such as red blood cells, clotting factors, and platelets. In vitro release studies

Multifrequency AFM integrating PeakForce tapping and higher eigenmodes for heterogeneous surface characterization

• Yanping Wei,
• Jiafeng Shen,
• Yirong Yao,
• Xuke Li,
• Ming Li and
• Peiling Ke

Beilstein J. Nanotechnol. 2025, 16, 2077–2085, doi:10.3762/bjnano.16.142

• piezoelectric actuator PD-II while the tip was retracted approximately 200 nm from the surface to avoid any influence of tip–sample interactions. The amplitude–frequency response was measured using the built-in lock-in amplifiers, and the operational excitation frequencies were determined by referencing the

• these different areas (see Supporting Information File 1, Figure S2). Mechanistic insights and operational advantages The material contrast generated by the superposed eigenmode phase originates from the cantilever’s high sensitivity to the gradient of tip–sample interactions and energy dissipation

• vibrational measurements is also recognized in concurrent AFM techniques [29]. This mechanism enables the high eigenmode to stably and sensitively probe the near-surface region and detect a broader spectrum of tip–sample interactions, which contributes to improved material property contrast in phase and

Molecular and mechanical insights into gecko seta adhesion: multiscale simulations combining molecular dynamics and the finite element method

• Yash Jain,
• Saeed Norouzi,
• Tobias Materzok,
• Stanislav N. Gorb and
• Florian Müller-Plathe

Beilstein J. Nanotechnol. 2025, 16, 2055–2076, doi:10.3762/bjnano.16.141

• dynamics to capture molecular interactions at the spatula–substrate interface and finite element method to simulate the mechanical behavior of the larger setal shaft. This hybrid approach enables synchronized simulations that resolve both fine-scale interfacial dynamics and overall structural deformation

• structures on their feet [1][2]. This bioadhesion mechanism has been studied extensively, especially for biomimetic adhesive applications [3][4][5][6][7][8][9]. Understanding these interactions presents a formidable challenge in biophysics and materials science due to the extremely small length and time

• gecko spatula was then used to bridge molecular interactions and macroscopic adhesion behavior. This mesoscale model accurately simulated spatula detachment from various substrates and matched experimental pull-off forces observed in AFM studies and pull-off pressures from united atom simulations of

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• drugs. Beyond pharmaceuticals, chiral chromatography is also essential in agrochemicals, flavors, fragrances, and many other chemicals whose stereochemistry plays a role in their biological interactions and sensory properties. The essence of chiral chromatography involves using chiral stationary phases

• or derivatizing agents, enabling the separation of enantiomers based on their interactions with these chiral entities. It is obvious that the transport properties of the two enantiomers must be different for them to be separated successfully. Transport in porous media is a topic with much broader and

• material. In essence, one sees here the interplay of all processes contributing to transport. Gathering information about the phenomena at short(er) distances and short(er) timescales and about the correlation between the mobility of guest species and intermolecular interactions with functionalized

Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• critical gap persists in thoroughly understanding the complex polymer–lipid interactions, particularly in systems designed for the simultaneous co-encapsulation of compounds with vastly different physicochemical properties, such as hydrophilic HA and lipophilic βCp. An in-depth understanding of these

• specific interactions is essential for precise modulation of encapsulation efficiency, ensuring system stability and achieving tailored kinetic release. Therefore, the primary objective of this study was to thoroughly investigate lipid–polymer interactions within coaxially electrospun PLA nanofibers

• number of beads and the formation of fibers with a more dispersed structure, likely reflecting insufficient polymer chain entanglement and Taylor cone instability. This behavior appears to result from interactions between NE-βCp droplets and HA chains, which may disrupt the jet and hinder solvent

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• has an absorption band at 248 nm, the wavelength change from 248 nm to 532 nm resulted in a significant decrease in absorption and consequent production of near-spherical NPs, similarly to those obtained in other solvents that do not directly participate in chemical interactions with the liquid

• . However, the additional 248 nm laser irradiation of the spherical NPs in methanol could transform NPs into nanowires. This underlines the importance of controlling chemical reactions during all stages of laser ablation and laser modification processes. Chemical interactions can become key parameters if

• chains in stabilizing ligands influences particle–particle coupling; therefore, the exchange of stabilizing agents will influence the overall shape of nanomaterials [43][44]. Further surface engineering by the control of ligand–ligand interactions can result in the formation of novel nanoarchitectures

Evaluating metal-organic precursors for focused ion beam-induced deposition through solid-layer decomposition analysis

• Benedykt R. Jany,
• Katarzyna Madajska,
• Aleksandra Butrymowicz-Kubiak,
• Franciszek Krok and
• Iwona B. Szymańska

Beilstein J. Nanotechnol. 2025, 16, 1942–1951, doi:10.3762/bjnano.16.135

• tested in FEBID processes. Preliminary studies of new or potential FEBID precursors employ electron ionization mass spectrometry and gas-phase cross-beam experiments (dissociative ionization and dissociative electron attachment), but more informative are investigations into the interactions of molecules

• decomposition mechanisms are proposed. Studies have been conducted on ion–molecule interactions in both solid and gas phases. Ultrahigh vacuum experiments on a few monolayers of FIBID precursors, such as [Ru(CO)4I2], [(η5-C5H5)Fe(CO)2Re(CO)5], and [Fe(CO)5], have been used to elucidate decomposition pathways

• . Gas-phase interactions between [Fe(CO)5] molecules and ions of helium, neon, argon, and krypton were carried out. However, the authors noted that these results may not accurately reflect the behavior of the precursor on the surface during actual FIBID processing since the conditions under which the

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• nanoparticle formulation is polyethylene glycol-modified (i.e., PEGylated) lipids (PEG lipids), which can significantly influence the stability, cell interactions, and overall effectiveness of LNP delivery vehicles. This review collates insights into the role of PEG lipids in LNPs by illustrating how the PEG

• review first reveals the localization and conformation of PEG lipids on the LNP surface, which is fundamental for understanding how PEG lipids contribute to nanoparticle stability and surface interactions. It then demonstrates how PEG density and chemical structure may influence the physicochemical

• providing steric stabilization and controlling interactions during blood circulation [9]. A study using small-angle neutron scattering (SANS) with selective deuteration has provided compelling insights into the lipid localizations. In a LNP formulation composed of MC3, DSPC, cholesterol, and DMPE-PEG2k at a

Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties

• Laryssa Ferreira do Nascimento Silva,
• Douglas Dourado,
• Thayse Silva Medeiros,
• Mariana Alice Gonzaga Gabú,
• Maria Cecilia Queiroga dos Santos,
• Daiane Rodrigues dos Santos,
• Mylena Lemos dos Santos,
• Gabriel Bezerra Faierstein,
• Rosângela Maria Rodrigues Barbosa and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132

• environmental factors such as temperature, nutrient availability, water quality, and ecological interactions. Higher temperatures accelerate growth, while food scarcity and competition can prolong this phase [46][47][48]. The life cycle of Ae. aegypti (Figure 1) begins with the deposition of eggs by adult

Programmable soliton dynamics in all-Josephson-junction logic cells and networks

• Vsevolod I. Ruzhickiy,
• Anastasia A. Maksimovskaya,
• Sergey V. Bakurskiy,
• Andrey E. Schegolev,
• Maxim V. Tereshonok,
• Mikhail Yu. Kupriyanov,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1883–1893, doi:10.3762/bjnano.16.131

• particular method of signal propagation delay influence depends on the realization of interneuron interactions and the need to adjust a particular interneuron connection. Moreover, these approaches can be combined into one by using a chain of superconductor diodes. Using cells with kinetic inductances, we

• ) after left-propagating soliton passage; (c, d) sequential right-propagating soliton interactions; (e) final left-propagating soliton recurrence. (a) Schematic of an all-Josephson-junction transmission line (all-JJTL) network with three inputs (In 1, In 2, In 3), three outputs (Out 1, Out 2, Out 3), and

Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength

• Shrutika Sawant,
• Anne Marie Power and
• J. Gerard Wall

Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129

• bond formation, metal chelation, and covalent interactions [6]. The byssal threads display a mechanical gradient, with regions proximal to the animal more elastic and distal regions stiffer and tougher [7]. This design allows for effective dissipation of hydrodynamic forces and maintains attachment of

Current status of using adsorbent nanomaterials for removing microplastics from water supply systems: a mini review

• Nguyen Thi Nhan and
• Tran Le Luu

Beilstein J. Nanotechnol. 2025, 16, 1837–1850, doi:10.3762/bjnano.16.127

• conventional treatments removing only 40–70%, especially struggling with smaller particles. Based mainly on mechanisms like electrostatic interactions, hydrophobic interactions, pore filling, hydrogen bonding, π–π stacking, and surface complexation, adsorbent nanomaterials achieve over 90% removal of MPs and

• materials provide a foundation for developing sustainable, effective solutions to mitigate MPs pollution in the water supply system. Keywords: adsorbent interactions; adsorbent nanomaterials; carbon-based adsorbents; metal-organic frameworks (MOFs); microplastics (MPs); Introduction Plastic materials have

• focused separately on sources and occurrences in the natural environment [13][14][15], contaminant interactions [16][17], risk assessments [18][19], extraction and analysis methods [20][21], and removal technologies of MPs [22][23] without focusing on water supply systems, which directly affect human

Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis

• Victória Louise Pinto Freire,
• Mariana Farias Alves-Silva,
• Johny W. de Freitas Oliveira,
• Matheus de Freitas Fernandes-Pedrosa,
• Alianda Maira Cornélio,
• Marcelo de Souza-Silva,
• Thayse Silva Medeiros and
• Arnóbio Antônio da Silva Junior

Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126

• on cytotoxicity in cutaneous leishmaniasis highlight the immunological interactions involving multiple cell types beyond macrophages, as well as the role of cytotoxic cells in disease progression and tissue damage, supporting the relevance of studying different cellular models, including fibroblasts

Further insights into the thermodynamics of linear carbon chains for temperatures ranging from 13 to 300 K

• Alexandre Rocha Paschoal,
• Thiago Alves de Moura,
• Juan S. Rodríguez-Hernández,
• Carlos William de Araujo Paschoal,
• Yoong Ahm Kim,
• Morinobu Endo and
• Paulo T. Araujo

Beilstein J. Nanotechnol. 2025, 16, 1818–1825, doi:10.3762/bjnano.16.125

• parameter; linear carbon chains; Raman spectroscopy; Introduction Phonons, their mutual interactions (ph–ph interactions), and their interactions with electrons (e–ph interactions) play fundamental roles in how materials respond to electric (e.g., difference of potentials), thermal (e.g., temperature

• phonons, and gain and loss of energy of carriers [1][2][10][17][24][25][26][27][28]. The phonon lifetime as well as the selection rules behind ph–ph and e–ph interactions determine the efficiency of such phonon emission and absorption [1][2][10][17][24][25][26][27][28]. Phonons need to be in an excited

• temperature (T)-dependent phenomena are ruled by anharmonic ph–ph interactions, which are also driven by three- and four-phonon processes, and by e–ph interactions [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Therefore, phonon assignments in

Piezoelectricity of layered double hydroxides: perspectives regarding piezocatalysis and nanogenerators

• Evgeniy S. Seliverstov,
• Evgeniya A. Tarasenko and
• Olga E. Lebedeva

Beilstein J. Nanotechnol. 2025, 16, 1812–1817, doi:10.3762/bjnano.16.124

• dodecylbenzene sulfonate-modified Ni/Co-LDH as a filler promoted the formation of the electroactive β-phase in PVDF-based electrospun nanocomposite fabrics [12]. The enhanced piezoelectric response was attributed to the realignment of PVDF dipoles in combination with their interfacial interactions with the

• interactions within the interfacial bonds induced internal structural reconstruction, which enhanced local polarization and N2 adsorption. As a result, the cleavage of N≡N bonds was accelerated, and the activation energy of the reaction was reduced. Unfortunately, this study also raises concerns regarding the

• carrier localization effects), or to interfacial electronic interactions that facilitate charge transfer. While these mechanisms may coexist, many publications lack the necessary control experiments (e.g., mechanical stimulation without light/oxidant, photocatalysis without stress, or defect-free samples

Electrical, photocatalytic, and sensory properties of graphene oxide and polyimide implanted with low- and medium-energy silver ions

• Josef Novák,
• Eva Štěpanovská,
• Petr Malinský,
• Vlastimil Mazánek,
• Jan Luxa,
• Ulrich Kentsch and
• Zdeněk Sofer

Beilstein J. Nanotechnol. 2025, 16, 1794–1811, doi:10.3762/bjnano.16.123

• MeV Ag ions. In this case, the electron stopping powers dominate near the surface. At 1.5 MeV, the Sn/Se ratio is lower (3.3–3.6), meaning that electronic interactions dominate, especially in the initial stages of penetration. The ions penetrate much deeper (Rp = 700–760 nm). At this energy, the

Exploring the potential of polymers: advancements in oral nanocarrier technology

• Rousilândia de Araujo Silva,
• Igor Eduardo Silva Arruda,
• Luise Lopes Chaves,
• Mônica Felts de La Roca Soares and
• Jose Lamartine Soares Sobrinho

Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122

• , secreted or cell-bound, which form a viscoelastic gel through entanglement and cross-linking. These properties contribute to the protective and lubricating functions of mucus. These functions are performed through steric, electrostatic, and hydrophobic interactions with various substances [6]. Mucin is an

• particles. Materials reduced to this scale exhibit alterations in their physicochemical properties, enhancing their interactions with molecular and cellular processes. Consequently, nanotechnology has diverse pharmaceutical applications, as the nanoencapsulation of drugs improves solubility and

• biodistribution while preventing undesirable interactions and degradation before reaching target tissues and cells [10]. Moreover, by overcoming the biological and chemical barriers of the body, nanotechnology increases the efficiency and effectiveness of therapeutic and diagnostic regimens, offering less

Advances of aptamers in esophageal cancer diagnosis, treatment and drug delivery

• Yang Fei,
• Hui Xu,
• Chunwei Zhang,
• Jingjing Wang and
• Yong Jin

Beilstein J. Nanotechnol. 2025, 16, 1734–1750, doi:10.3762/bjnano.16.121

• three-dimensional structures that specifically recognize and bind to SOX2. This binding effectively disrupts SOX2–DNA interactions, thereby establishing a novel therapeutic strategy for traditionally undruggable targets. Most recently, researchers have developed peptide-based aptamers targeting SOX2

• interactions [79], begin to emerge. Chen et al. [80] showed that CDP and SOX2 expression levels were highly correlated with late ESCC, verified that CDP and SOX2 interacted in ESCC cell lines (KYSE450 and KYSE30 cells), and confirmed the interaction interface between these two proteins. Peptide aptamer p58

• spontaneously intercalate into GC-rich regions of aptamers through non-covalent interactions. This characteristic not only enhances tumor-specific accumulation but also significantly reduces cardiotoxicity. This way of inserting the drug directly between the bases of the aptamer and forming physical conjugation

Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease

• Niédja Fittipaldi Vasconcelos,
• Almerinda Agrelli,
• Rayane Cristine Santos da Silva,
• Carina Lucena Mendes-Marques,
• Isabel Renata de Souza Arruda,
• Priscilla Stela Santana de Oliveira,
• Mércia Liane de Oliveira and
• Giovanna Machado

Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120

• better stability, smaller droplet size, and improved solubilization of hydrophobic compounds, making them more suitable for superficial ocular conditions like dry eye, where sustained bioavailability and tear film compatibility are vital [53]. Liposomes may also face practical issues due to interactions

• assessed using the Shapiro–Wilk and Levene’s tests, respectively. A three-way ANOVA was then performed, considering the factors exposure time (24 and 72 h), concentration (0.65 to 13 mg·mL−1), and treatment (OphtNE-3.70% and OphtNE-3.66%(K1%)). Two-way interactions were further examined using post hoc

• molecular structure [71][72]. This results in weaker intermolecular interactions, reducing the oil’s viscosity [73]. A lower viscosity in LO can facilitate the formation and stability of micelles by allowing surfactant molecules to move more freely, promoting their rapid formation and maintaining stability

Ambient pressure XPS at MAX IV

• Mattia Scardamaglia,
• Ulrike Küst,
• Alexander Klyushin,
• Rosemary Jones,
• Jan Knudsen,
• Robert Temperton,
• Andrey Shavorskiy and
• Esko Kokkonen

Beilstein J. Nanotechnol. 2025, 16, 1677–1694, doi:10.3762/bjnano.16.118

• ; batteries; catalysis; corrosion; Review Ambient pressure XPS Electron spectroscopy has significantly contributed to the understanding of chemical and physical processes that govern the complex interactions between a solid surface and its environment. These processes play crucial roles in phenomena such as

• working range of APXPS. Time-resolved APXPS has proven especially powerful for studying the initial ALD cycles, where the chemical interactions at the surface are most critical [54][55][56][57][58][59][60]. At MAX IV, the SPECIES beamline has led the development of ALD studies using APXPS. A dedicated

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• in patent searches, as only two publications were found. Self-assembled nanoparticles are structures with adapted particle interactions to achieve desired purposes [37]. In the pharmaceutical field, these nanoparticles have potential as vehicles for anticancer drugs due to their biocompatibility

• spontaneously from the organization of active or natural compounds, without the presence of a carrier material or excipients. Their stability is due to the presence of intermolecular interactions, such as electrostatic forces, hydrogen bonding, π–π stacking, and hydrophobic interactions [104][105]. Among the

Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion

• Philippe de Castro Mesquita,
• Karla Samara Rocha Soares,
• Manoela Torres-Rêgo,
• Emanuell dos Santos-Silva,
• Mariana Farias Alves-Silva,
• Alianda Maira Cornélio,
• Matheus de Freitas Fernandes-Pedrosa and
• Arnóbio Antônio da Silva-Júnior

Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115

• , peptides, DNA, RNA, antigens, and oligonucleotides to be efficiently incorporated through electrostatic interactions [35][36]. Moreover, some studies showed the interesting association of nanoparticles containing PEI for incorporation of DNA in gene transfection and BSA protein [14][37]. The

Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review

• Nayanathara O Sanjeev,
• Manjunath Singanodi Vallabha and
• Rebekah Rubidha Lisha Rabi

Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114

• leading to mass mortality. Such interactions amplify the ecological consequences of MPs in the environment. Consequently, the ingestion of MPs embedded with contaminants can contribute to the transfer of toxic substances across terrestrial and aquatic food webs [46]. In freshwater ecosystems, MPs can

• the process. The removal of MPs by adsorbents primarily relies on hydrophobic interactions, electrostatic attraction and hydrogen bonding, which are influenced by their surface characteristics. Among various adsorbents, activated carbon and biochar have gained wide attention for treating water

• capabilities due to electrostatic interactions, making them highly effective in capturing MPs. Their fast adsorption kinetics support rapid water purification, and surface modifications can further enhance their performance and selectivity. These membranes are also versatile and applicable in various treatment

Few-photon microwave fields for superconducting transmon-based qudit control

• Irina A. Solovykh,
• Andrey V. Pashchenko,
• Natalya A. Maleeva,
• Nikolay V. Klenov,
• Olga V. Tikhonova and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2025, 16, 1580–1591, doi:10.3762/bjnano.16.112

• the highest possible excited transmon state with n = k0. An increase in the nonlinearity of the transmons leads to a significant reduction in the period of Rabi oscillations, tR, and the beat frequency, tbeat, as shown in Figure 2a. When nonlinear interactions dominate, high-energy excitations are

Photocatalytic degradation of ofloxacin in water assisted by TiO₂ nanowires on carbon cloth: contributions of H₂O₂ addition and substrate absorbability

• Iram Hussain,
• Lisha Zhang,
• Zhizhen Ye and
• Jin-Ming Wu

Beilstein J. Nanotechnol. 2025, 16, 1567–1579, doi:10.3762/bjnano.16.111

• unsatisfactory interaction with target contaminants diminishes photocatalytic degradation efficiency in water. Here, we present a mild solution method to precipitate anatase TiO2 nanowire arrays, measuring 1.5 μm in thickness, over carbon cloth to ensure substantial interactions with target pollutants and, in

• (pH 2) and highly basic (pH 12) conditions reduce the degradation efficiency, likely due to reduced ROS stability or altered surface interactions. It demonstrates that the carbon cloth-supported TiO2 nanowires are capable of functioning in wastewater with a wide pH range. The active radical species