3D Nanoprinting via laser-assisted electron beam induced deposition: growth kinetics, enhanced purity, and electrical resistivity

• Brett B. Lewis,
• Robert Winkler,
• Xiahan Sang,
• Pushpa R. Pudasaini,
• Michael G. Stanford,
• Harald Plank,
• Raymond R. Unocic,
• Jason D. Fowlkes and
• Philip D. Rack

Beilstein J. Nanotechnol. 2017, 8, 801–812, doi:10.3762/bjnano.8.83

• 1 nm was used while varying dwell times per pixel. A previously developed computer aided design program was used to determine the dwell times per pixel necessary to construct complex shapes. The beam energy and current for all patterns was set at 30 keV and 21 pA, respectively. Laser delivery system

• automated axial translation. An objective lens located at the shaft tip projects the 100 µm diameter laser spot with a Gaussian distribution at the coincidence point between the focused electron beam and the gas injection systems. The laser delivery system is a prototype under development by Waviks, Inc

• of different growth conditions. Schematic illustrating the experimental system which includes a laser delivery system, precursor and co-reactant gas delivery systems, and the electron beam all coincident to the same region. The schematic also illustrates the deposition of the 3D suspended bridge

Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone

• Huijuan Zhang,
• Fuqiang Wu,
• Yazhen Li,
• Xiping Yang,
• Jiamei Huang,
• Tingting Lv,
• Yingying Zhang,
• Jianzhong Chen,
• Haijun Chen,
• Yu Gao,
• Guannan Liu and
• Lee Jia

Beilstein J. Nanotechnol. 2016, 7, 1861–1870, doi:10.3762/bjnano.7.178

• mechanism of action. However, application of MIF is limited by its poor water solubility and low oral bioavailability. In this work, we developed a drug delivery system based on chitosan nanoparticles (CNs) to improve its bioavailability and anticancer activity. The MIF-loaded chitosan nanoparticles (MCNs

• curve from 0 to 24 h compared with free MIF. These results demonstrated that MCNs could be developed as a potential delivery system for MIF to improve its anticancer activity and bioavailability. Keywords: anticancer; chitosan; drug delivery; mifepristone; nanoparticles; pharmacokinetics; sustained

• increased its efficacy by sustained release to reduce drug crystallization [33]. These results suggested that MCNs might be a good drug delivery system for delivery of MIF for cancer therapy. Pharmacokinetic study In our previous study, we found MIF showed distinct pharmacokinetic differences between

Gold nanoparticles covalently assembled onto vesicle structures as possible biosensing platform

• M. Fátima Barroso,
• M. Alejandra Luna,
• Juan S. Flores Tabares,
• Cristina Delerue-Matos,
• N. Mariano Correa,
• Fernando Moyano and
• Patricia G. Molina

Beilstein J. Nanotechnol. 2016, 7, 655–663, doi:10.3762/bjnano.7.58

• methodology. This nanomaterial offers interesting possibilities and future applications such as its use in the design of immunosensors. Moreover, the developed methodology can be a promising candidate for other applications as optical addressable delivery system and affinity columns. Experimental Synthesis of

Comparison of the interactions of daunorubicin in a free form and attached to single-walled carbon nanotubes with model lipid membranes

• Dorota Matyszewska

Beilstein J. Nanotechnol. 2016, 7, 524–532, doi:10.3762/bjnano.7.46

• includes liposomes, which are commercially available daunorubicin formulation (Daunoxome®) used in the treatment of Kaposi’s sarcoma [6]. Despite that, there are still numerous studies on the improvement of this drug delivery system aiming at enhancing drug loading into cells by using specific interactions

• . Moreover, it was shown that the surface concentration of the drug on the electrode surface is similar for both the drug in a free form and the drug–nanocarrier adduct. This observation proves that application of single-walled carbon nanotubes as drug delivery system allows for the transport of the

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

• Manuel Häuser,
• Klaus Langer and
• Monika Schönhoff

Beilstein J. Nanotechnol. 2015, 6, 2504–2512, doi:10.3762/bjnano.6.260

• Nanoparticles (NP) of poly(lactic-co-glycolic acid) (PLGA) represent a promising biodegradable drug delivery system. We suggest here a two-step release system of PLGA nanoparticles with a pH-tunable polymeric shell, providing an initial pH-triggered step, releasing a membrane-toxic cationic compound. PLGA

• . We present here the idea of a two-step delivery system consisting of core–shell nanoparticles. The outer shell is susceptible to changes of the pH value, such that the release of a membrane-toxic cationic compound is triggered by a reduced pH value in the endolysosomal compartment of the cells. The

Nanofibers for drug delivery – incorporation and release of model molecules, influence of molecular weight and polymer structure

• Jakub Hrib,
• Jakub Sirc,
• Radka Hobzova,
• Zuzana Hampejsova,
• Zuzana Bosakova,
• Marcela Munzarova and
• Jiri Michalek

Beilstein J. Nanotechnol. 2015, 6, 1939–1945, doi:10.3762/bjnano.6.198

• delivery system with the diffusion rate of the therapeutic agent stable throughout the life. The structure of the nanofibrous drug delivery system plays a key role in the drug release process. The fiber diameter, specific surface area, size and total volume of pores significantly influence the convection

Filling of carbon nanotubes and nanofibres

• Reece D. Gately and
• Marc in het Panhuis

Beilstein J. Nanotechnol. 2015, 6, 508–516, doi:10.3762/bjnano.6.53

• delivery and medical imaging applications of SWCNT and MWCNTs have been identified, this line of research has only very recently emerged [117][118][119]. Further investigations into the selective binding of functional groups and various viruses or tumours could provide for an effective drug delivery system

Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes

• Julia M. Tan,
• Jhi Biau Foo,
• Sharida Fakurazi and
• Mohd Zobir Hussein

Beilstein J. Nanotechnol. 2015, 6, 243–253, doi:10.3762/bjnano.6.23

• suggests that the newly synthesized nanohybrid is a promising drug delivery system for the delivery of LD to nervous system. Experimental Materials Short, carboxyl single-walled carbon nanotubes (SWCNT–COOH) produced by chemical vapour deposition with a diameter of 1–2 nm an purity of 90% (w/w %) were

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• complex is considered to be useful as a drug delivery system (DDS) for anticancer compounds since it formed a stable polymeric micelle in water. The resistance of B16F10 melanoma cells to PTX was shown clearly through a maximum survival curve. Conversely, the DDMC/PTX complex showed a superior anticancer

• cancer cells; paclitaxel; supramolecular complex; Review Introduction As a means of delivering a drug to a target effectively, the enhanced permeation and retention (EPR) effect and reticuloendothelial system (RES) were enabled by using a polymer drug delivery system (DDS), and it is thought to

• an anticancer agent can be prevented if the agent promotes positive allosteric modulation according to the enzyme reaction model of a 1:1 ratio of a substrate and enzyme, which is the ratio utilized in vivo. Gene delivery system On the other hand, development of the gene delivery system in field of

Carbon-based smart nanomaterials in biomedicine and neuroengineering

• Antonina M. Monaco and
• Michele Giugliano

Beilstein J. Nanotechnol. 2014, 5, 1849–1863, doi:10.3762/bjnano.5.196

• presence of reactive functional groups and of localised π-electrons, which promote the π–π bond with aromatic compounds, render graphene a suitable candidate as a drug delivery system. Several remarkable studies in this area have been performed, including those involving the functionalisation of GO by PEG

Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages

• Dagmar A. Kuhn,
• Dimitri Vanhecke,
• Benjamin Michen,
• Fabian Blank,
• Peter Gehr,
• Alke Petri-Fink and
• Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2014, 5, 1625–1636, doi:10.3762/bjnano.5.174

• pathway of a NP will have direct consequences on its intracellular localization; hence, understanding the overall NP distribution in a specific compartment, such as endosomes, lysosomes or others, might provide some interesting suggestions for developing a future drug delivery system. To gain more insight

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

• Paula M. Castillo,
• Mario de la Mata,
• Maria F. Casula,
• José A. Sánchez-Alcázar and
• Ana P. Zaderenko

Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• delivery system for bone metastatic prostate cancer was developed, characterized, and evaluated in vitro. NDs were conjugated with the Asp–Gly–Glu–Ala (DGEA) peptide to target α2β1 integrins over-expressed in prostate cancers during metastasis. To facilitate drug delivery, DOX was adsorbed to the surface

• work, we developed a novel ND meditated drug delivery system to increase specificity of DOX by utilizing DGEA to target the α2β1 integrins overexpressed in metastatic prostate cancers. ND-DGEA conjugates and the ND-DGEA+DOX system were synthesized and evaluated for multifunctional applications (i.e

• effects of the drug delivery system were due to the combination of enhanced targeting and drug delivery instead of potential toxicity of ND or DGEA peptide, PC3 cells were also exposed to ND, ND-DGEA, and free DGEA. The cell viability was quantified with a 3-(4,5-dimethylthiazol-2-yl)-5-(3

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

• after background subtraction). The ratio R was then determined by normalizing the total pixel intensity of this region of interest to its total area. HT treatment Two different heating modes, namely (1) an incubator and (2) a laser/NP HT delivery system, were used for in vitro studies. Detailed

Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• physiological conditions, which is highly desired for a cell-based delivery system. We have established that when Mo/Ma cells are used as carriers, the tumor-homing process takes about one day. Their robust stability will ensure the integrity of the MNPs after delivery to the tumor site. The uptake efficiency