Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• , hydrogen bonding, disulfide bond formation, or physical entanglement of polymers within the mesh-like mucus structure [9][10]. Sodium alginate is a linear polysaccharide composed of 1,4-linked β-ᴅ-mannuronic acid and α-ʟ-guluronic acid residues. Alginate can be used to form porous matrix-type drug delivery

• surface area for adhesion. Also, mucus penetration would be hindered because of the mesh-like structure of mucin. For therapeutics that have gastric mucosa as target, this might limit the efficiency and decrease the drug absorption at the site. A smaller particle size, however, is advantageous because of

• used for nanoparticle preparation. The nanoscale size is particularly important in mucoadhesive systems designed for gastric delivery because of the mesh-like structure of gastric mucus. Since the pore size in gastric mucus is around 500 nm [9], the smaller the nanoparticle, the better the mucus

Vortex lattices of layered HTSCs at different vortex–vortex interaction potentials

• Valerii P. Lenkov,
• Anastasia N. Maksimova,
• Anna N. Moroz and
• Vladimir A. Kashurnikov

Beilstein J. Nanotechnol. 2025, 16, 362–370, doi:10.3762/bjnano.16.27

• the magnetic field penetrates the superconductor in the form of Abrikosov vortices [1]. In high-temperature superconductors (HTSCs), such as Y- and Bi-based cuprates, the vortex lattice is further complicated since these compounds have a layered structure [2][3][4][5][6]. The vortex filament in these

• superconductors can be represented as a stack of pancakes, that is, flat vortices located in the CuO planes and connected by Josephson interaction through interplanar gaps. The vortex structure in layered HTSCs is still a subject of research. In [7], it was shown that Pb doping increases the two-dimensional

• with respect to the superconducting planes. The phase diagram of the vortex system becomes even more complex in an inclined magnetic field. As studies [9][10][11] have shown, the structure of the vortex lattice depends on the anisotropy parameter of the superconductor in the form of the Josephson

Pulsed laser in liquid grafting of gold nanoparticle–carbon support composites

• Madeleine K. Wilsey,
• Teona Taseska,
• Qishen Lyu,
• Connor P. Cox and
• Astrid M. Müller

Beilstein J. Nanotechnol. 2025, 16, 349–361, doi:10.3762/bjnano.16.26

• primarily allow the passage of anions, proton transport or leakage, can occur because of the inherent structure and presence of water within the membrane [72][73][74]. This way, anodically generated protons can cross over into the cathode compartment and produce CO2 from bicarbonate. At a constant current

Tailoring of physical properties of RF-sputtered ZnTe films: role of substrate temperature

• Kafi Devi,
• Usha Rani,
• Arun Kumar,
• Divya Gupta and
• Sanjeev Aggarwal

Beilstein J. Nanotechnol. 2025, 16, 333–348, doi:10.3762/bjnano.16.25

• temperature are amorphous; those deposited at other substrate temperatures are polycrystalline with a cubic zincblende structure and a preferred orientation along the [111] direction. An increase in crystallite size (from 37.60 ± 0.42 Å to 68.88 ± 1.04 Å) is observed with increased substrate temperature. This

• resistivity of the films depends on the structure, grain boundary defects, and surface morphology of the films. These properties can be altered by varying the deposition method as well as the deposition parameters. In literature, there are several reports of zinc telluride films deposited using various

• . Bellakhder et al. [13] have investigated the impact of varying RF power on the structure, optical, and electrical properties of RF-sputtered ZnTe films and found that the deposited films are highly resistive and have low refractive index because of the polycrystalline nature of films. Isik et al. [14

Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation

• Braham Dutt Arya,
• Sandeep Mittal,
• Prachi Joshi,
• Alok Kumar Pandey,
• Jaime E. Ramirez-Vick,
• Govind Gupta and
• Surinder P. Singh

Beilstein J. Nanotechnol. 2025, 16, 316–332, doi:10.3762/bjnano.16.24

• significant increase in the expression of beclin-1 and ATG-7 was observed in GO–Chl-exposed A549 cells. Beclin-1 is a three-structure-domain protein (BH-3 only, CCD, and ECD) and is key in the regulation of autophagy in mammalian cells [68]. Recent studies reveal that elevated expression levels of beclin-1

Fabrication and evaluation of BerNPs regarding the growth and development of Streptococcus mutans

• Tuyen Huu Nguyen,
• Hong Thanh Pham,
• Kieu Kim Thanh Nguyen,
• Loan Hong Ngo,
• Anh Ngoc Tuan Mai,
• Thu Hoang Anh Lam,
• Ngan Thi Kim Phan,
• Dung Tien Pham,
• Duong Thuy Hoang,
• Thuc Dong Nguyen and
• Lien Thi Xuan Truong

Beilstein J. Nanotechnol. 2025, 16, 308–315, doi:10.3762/bjnano.16.23

• formation. The results demonstrated that BerNPs were produced with an average particle size of 40–65 nm. The chemical structure of BerNPs remained consistent with that of berberine, with no modifications occurring during nanoparticle preparation. The BerNPs exhibited the ability to inhibit S. mutans, with

• minimum inhibitory concentration and minimum bactericidal concentration values of 78.1 and 312.5 µg/mL, respectively. BerNPs caused significant damage to S. mutans cells, disrupting the cell membrane structure, and leading to cell lysis and death. Additionally, BerNPs effectively inhibited the biofilm

• products containing BerNPs, which can be used in the care and treatment of dental caries and other dental problems. Results and Discussion Production of BerNPs In this study, the raw berberine powder exhibited a crystalline structure with particle sizes ranging from 15 to 35 µm (Figure 1A). Ball milling is

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• ]. Additionally, PVA contributes to reducing the crystallinity of the chitosan structure [19]. Because of their unique and exceptional properties, nanofibrous membranes have become prominent materials for a wide range of applications [20]. Throughout their time of use, electrospun fibers are exposed to

• . For example, collagen is one substance used in electrospinning that has low strength [22]. Its loose structure and weak composition are the reasons behind its inherent poor mechanical performance. Electrospinning solutions with non-Newtonian fluids come next. They exhibit unstable properties

• stress on that fiber and weaken the overall structure [25]. With advancements in technology for producing nanofibers through electrospinning, various methods and techniques have been developed to enhance the mechanical properties of electrospun nanofibers. The objective of this review is to explore

Emerging strategies in the sustainable removal of antibiotics using semiconductor-based photocatalysts

• Yunus Ahmed,
• Keya Rani Dutta,
• Parul Akhtar,
• Md. Arif Hossen,
• Md. Jahangir Alam,
• Obaid A. Alharbi,
• Hamad AlMohamadi and
• Abdul Wahab Mohammad

Beilstein J. Nanotechnol. 2025, 16, 264–285, doi:10.3762/bjnano.16.21

• degradation and solid–liquid separation are also commonly used in making the pollutants non-toxic or non-hazardous [13][23]. It should be noted that many of the conventional methods fail in degrading antibiotics completely since most antibiotics are very complex in structure and are even resistant to

• advanced methods, including sol–gel, hydrothermal, solvothermal, precipitation and template-assisted techniques [53]. The synthesis method chosen often depends on factors such as the desired crystal structure, particle size, surface area, and photocatalytic activity required for the specific application

• have taken two approaches to developing effective solar light-activated semiconductor-based photocatalysts. The main approach is to improve the absorption of visible light of semiconductor materials by including metal or nonmetal elements. This augmentation can modify the energy band structure or

Preferential enrichment and extraction of laser-synthesized nanoparticles in organic phases

• Theo Fromme,
• Maximilian L. Spiekermann,
• Florian Lehmann,
• Stephan Barcikowski,
• Thomas Seidensticker and
• Sven Reichenberger

Beilstein J. Nanotechnol. 2025, 16, 254–263, doi:10.3762/bjnano.16.20

• correlations between the particle distribution, their size, and the particles’ degree of oxidation and crystal structure to differentiate the cause of this behavior, which is beyond this phase selectivity study. In this context, the systematic variation of the TMS via a systematic solvent chain length series

• requires a detailed investigation of the nanoparticles’ surface chemistry, composition, and crystal structure, ideally complemented by cycling studies after catalysis experiments. Overall, this study, however, provides first evidence that the phase selectivity and recyclability of nanoparticles fabricated

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• changes in the structure of the CNs and TMZ after irradiation were observed. With single and dual functionalization, formulations with relatively high TMZ loading efficiency and drug content were prepared. They exhibited homogeneous particle size distributions and mean particle sizes and surface charges

• formulations of the hybrid CN MWCNTs-G compared to the corresponding MWCNTs were characterized by a similar or slightly higher TMZ content, larger particle size, similar surface charge, and slightly faster TMZ release, which can be attributed to the planar structure of graphene that promotes TMZ binding to the

• to changes in the structure of RNA, protein chromatin structure, gene expression and replication, and synthesis and repair of DNA [30]. It has also been shown that TMZ has radiosensitizing effects [31][32], increasing the degradation of DNA strains and cell death when combined with RT, which is a

Synthesis and the impact of hydroxyapatite nanoparticles on the viability and activity of rhizobacteria

• Bedah Rupaedah,
• Indrika Novella,
• Atiek Rostika Noviyanti,
• Diana Rakhmawaty Eddy,
• Anna Safarrida,
• Abdul Hapid,
• Zhafira Amila Haqqa,
• Suryana Suryana,
• Irwan Kurnia and
• Fathiyah Inayatirrahmi

Beilstein J. Nanotechnol. 2025, 16, 216–228, doi:10.3762/bjnano.16.17

• enhances the survival of rhizobacteria but also promotes plant growth by providing essential nutrients. nHA emerges as a remarkable biomaterial widely embraced as a nanocarrier, primarily because of its porous structure that facilitates precise and efficient conduction and release of various materials [16

• to the nHA carrier material is not fully understood. However, the structure of nHA, characterized by its voids and crevices, provides an environment conducive to the growth and survival of rhizobacteria, a phenomenon known as biological fixation [33]. Figure 6, along with Table 3 and Table 4, shows

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• boundaries of thermal therapy, achieving unparalleled therapeutic effects through their diverse composite structures and demonstrating enormous potential in promoting retinal drug delivery and photoacoustic imaging. This paper provides a comprehensive summary of the structure–activity relationship between

• nanomaterials for treating various ophthalmic diseases, including ocular tumors, glaucoma, cataracts, vitreous opacity, endophthalmitis, and decreased visual acuity. It also summarizes the structure–activity relationships between the photothermal properties of these materials and novel therapeutic mechanisms

• , including exceptional biocompatibility, biodegradability, wide availability, low cost, and a highly tunable structure, making them well-suited for such uses [67][68][69][70][71]. 2.3 Inorganic semiconductor materials Inorganic semiconductor materials, such as TiO2, SiO2, and Fe2O3, possess conductivity

Probing the potential of rare earth elements in the development of new anticancer drugs: single molecule studies

• Josiane A. D. Batista,
• Rayane M. de Oliveira,
• Carlos H. M. Lima,
• Milton L. Lana Júnior,
• Virgílio C. dos Anjos,
• Maria J. V. Bell and
• Márcio S. Rocha

Beilstein J. Nanotechnol. 2025, 16, 187–194, doi:10.3762/bjnano.16.15

• potential to be used in the development of novel chemotherapeutic drugs. The results found here show that, in general, rare earth elements are promising agents to be used in the development of new anticancer drugs, presenting high binding equilibrium constants with the double helix structure. Furthermore

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

• specific synthetic route, solvents, structure-directing agents, and precursors, can impact the final structure and yield of the synthesized MOFs. For more details on these effects, the interested reader is referred to the thorough review of MOF synthesis by Stock and Biswas [111]. In addition to MOF pore

• formed may not fully represent the structure of the fabricated MOF-based MMMs. While electron microscopy offers a highly detailed qualitative analysis of specific regions within the membrane, methods such as Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) spectroscopy

• possible to compare how various modifications to the MOF-based MMM system change the functional groups within the final membrane [122][125][128]. Similar to FTIR, NMR provides insights into the chemical nature of the membrane but offers more detailed information about its chemical structure [141]. XRD

Clays enhanced with niobium: potential in wastewater treatment and reuse as pigment with antibacterial activity

• Silvia Jaerger,
• Patricia Appelt,
• Mario Antônio Alves da Cunha,
• Fabián Ccahuana Ayma,
• Ricardo Schneider,
• Carla Bittencourt and
• Fauze Jacó Anaissi

Beilstein J. Nanotechnol. 2025, 16, 141–154, doi:10.3762/bjnano.16.13

• BEPh) and the same obtained after adsorption/photocatalysis of MB (A-BEPh, A-BEOx, A-BEPhP, and A-BEOxP) show the characteristic diffraction peak at approximately 26.4° (2θ) indicating that the niobium modification did not destroy the structure of the montmorillonite layer [14]. However, the relative

• ] observed the same results, and indicated that the bentonite clay modified with niobium initiated the inorganic pillarization process from the polyhydroxyniobium process [14][15]. The supposed structure of bentonite clay modified with niobium phosphate and niobium oxide proposed in this study can be

• -BEOxP samples exhibit a set of bands in the region from 1477 to 1277 cm−1 typical for the identification of the MB dye, indicating the presence of the dye in the clay structure [18]. Figure 5 shows the XPS analysis of niobium in BEOx and BEPh samples (Figure 4a and Figure 4b, respectively). The Nb 3d

TiO₂ immobilized on 2D mordenite: effect of hydrolysis conditions on structural, textural, and optical characteristics of the nanocomposites

• Marina G. Shelyapina,
• Rosario Isidro Yocupicio-Gaxiola,
• Gleb A. Valkovsky and
• Vitalii Petranovskii

Beilstein J. Nanotechnol. 2025, 16, 128–140, doi:10.3762/bjnano.16.12

• complementary characterization techniques, including XRD, SEM-EDX, TGA, N2 sorption, NMR, XPS and UV–vis spectrometry. It was observed that treatment in 70% ethanol solution preserves the ordered layered structure of 2D mordenite because TEOT hydrolysis is slowed down. This, in turn, leads to higher

• cetyltrimethylammonium bromide (CTAB) layers. The latter method involves the synthesis of layered 2D zeolites in the presence of CTAB and organic structure directing agents (OSDAs), followed by calcination to remove them from the resulting products [1]. The choice of the OSDA determines not only the interlamellar

• treatment in air is eliminated in the process of crystallization at 400–550 °C; thus, titanium dioxide nanoparticles are obtained [29]. In this study we investigate in detail the influence of the hydrolysis medium and the duration of the hydrolytic process on composition, local structure, morphology

Comparison of organic and inorganic hole transport layers in double perovskite material-based solar cell

• Deepika K and
• Arjun Singh

Beilstein J. Nanotechnol. 2025, 16, 119–127, doi:10.3762/bjnano.16.11

• essential issue for practical applications in the future. The structure of PSCs is ABX3, where A and B are the cationic sites and X is the anionic site. In double perovskite solar cells (DPSCs), the unit cell is twice that of the perovskite, that is, A2BB′O6. It has two cations at the sites B and B′ with

• , the double perovskite layer is sandwiched between the CTLs. In 2021, Kumar et al., reported a PCE of 9.68% for a La2NiMnO6 (LNMO)-based device structure after the bandgap had been optimized using the SCAPS-1D software [12]. In 2022, Porwal et al. reported a PCE of 23.64% with Cs2SnI6 as double

• and shunt resistance, interfacial defect density, and various metal electrodes were studied. An efficiency of 18.89% with VOC = 0.7919 V, JSC = 27.89 mA/cm2, and FF = 85.52% was reported for the device structure FTO/WS2/La2NiMnO6/Cu2O/Au [15][16]. In 2023, the highest optimized efficiency of 24.08

Nanocarriers and macrophage interaction: from a potential hurdle to an alternative therapeutic strategy

• Naths Grazia Sukubo,
• Paolo Bigini and
• Annalisa Morelli

Beilstein J. Nanotechnol. 2025, 16, 97–118, doi:10.3762/bjnano.16.10

• macrophages in the spleen and lymph nodes, that sequester them. This occurs often independent of their design and structure [7]. Although a significant challenge, this interaction presents a unique clinical application opportunity. Macrophages are involved in the pathogenesis of several diseases and thus can

• ]. NCs enhance the delivery of biological therapeutics, and endosomal escape can be controlled by tuning their structure and physicochemical properties. For example, NCs designed with “proton sponge” capability contain materials that adsorb and buffer protons under acidic conditions and, typically, have

• long-term consequence of chronic liver fibrosis, leads to impaired liver function. HCC, the most common form of primary liver cancer, is often associated with underlying liver conditions like hepatitis and cirrhosis [82]. By exploiting the liver’s unique vascular structure and the natural propensity of

Characterization of ZnO nanoparticles synthesized using probiotic Lactiplantibacillus plantarum GP258

• Prashantkumar Siddappa Chakra,
• Aishwarya Banakar,
• Shriram Narayan Puranik,
• Vishwas Kaveeshwar,
• C. R. Ravikumar and
• Devaraja Gayathri

Beilstein J. Nanotechnol. 2025, 16, 78–89, doi:10.3762/bjnano.16.8

• bacteria contribute to the creation of NPs by acting as ligands for the metal ions. Extracellular and intracellular enzymes also play a role in this process, acting as capping, stabilizing, and reducing agents [9]. The study focuses on using LAB to synthesize ZnO NPs with wurtzite (B4) structure under

• biosynthesis of ZnO NPs. The formation of a white precipitate at the flask’s bottom served as an indicator of ZnO NP production. XRD analysis The XRD patterns revealed a strong agreement with the hexagonal wurtzite structure, which is characteristic of ZnO NPs. This assertion was substantiated by comparison

• with data from the JCPDS card no.89-7102. Remarkably, there were no indications of any other phases, indicating a high purity of the ZnO NPs. The XRD reflections were remarkably well-defined and narrow. This signifies the distinctive crystalline arrangement, indicating a robust crystalline structure

Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research

• Benjamin Punz,
• Maja Brajnik,
• Joh Dokler,
• Jaleesia D. Amos,
• Litty Johnson,
• Katie Reilly,
• Anastasios G. Papadiamantis,
• Amaia Green Etxabe,
• Lee Walker,
• Diego S. T. Martinez,
• Steffi Friedrichs,
• Klaus M. Weltring,
• Nazende Günday-Türeli,
• Claus Svendsen,
• Christine Ogilvie Hendren,
• Mark R. Wiesner,
• Martin Himly,
• Iseult Lynch and
• Thomas E. Exner

Beilstein J. Nanotechnol. 2025, 16, 57–77, doi:10.3762/bjnano.16.7

• , NanoFASE adopted the concept for their mesocosm study reporting. In collaboration with their NanoCommons data shepherd [29], the NanoFASE project adopted the instance map approach for project-wide data management to structure the data reporting of the complex mesocosm experiments; the researchers used a

• innovation processes is also evident. Methodological Approach Definition of the instance map concept The original instance maps, used as organisational structure in the data curation efforts for the NIKC database [27], enabled users to visually document nanomaterial transformations while capturing the

• characterisation reporting, its terminology, classification, and metadata. A standard structure containing this type of information relating to (i) materials characterisation (meta)data, termed CHADA (CHAracterisation DAta and description of a characterisation experiment), has recently been proposed [42

Advanced atomic force microscopy techniques V

• Philipp Rahe,
• Ilko Bald,
• Nadine Hauptmann,
• Regina Hoffmann-Vogel,
• Harry Mönig and
• Michael Reichling

Beilstein J. Nanotechnol. 2025, 16, 54–56, doi:10.3762/bjnano.16.6

• oscillation amplitude yields a signal with a complex temporal structure. This is due to the interferometer signal being limited in amplitude by the spatial periodicity of the cavity light field. By the fit of a model function to the measured time-domain interferometer signal, all displacement signal

Theoretical study of the electronic and optical properties of a composite formed by the zeolite NaA and a magnetite cluster

• Joel Antúnez-García,
• Roberto Núñez-González,
• Vitalii Petranovskii,
• H’Linh Hmok,
• Armando Reyes-Serrato,
• Fabian N. Murrieta-Rico,
• Mufei Xiao and
• Jonathan Zamora

Beilstein J. Nanotechnol. 2025, 16, 44–53, doi:10.3762/bjnano.16.5

• with a three-dimensional structure comprising pores and cavities of molecular dimensions. This unique structure enables them to operate as molecular sieves, allowing molecules smaller than the pore size to pass through while blocking the diffusion of larger ones. Furthermore, the physicochemical

• response are intricately linked to factors such as the chemical composition, particle size, structure, and geometry of these materials [18][19][20]. Hence, it is generally undesirable for nanoscale materials to undergo structural alterations because of environmental exposure or to change their properties

• structure and properties of these systems is very limited. Besides, to the best of our knowledge, there is a dearth of theoretical literature specifically addressing the study of magnetic clusters within zeolites. With this motivation, the present study evaluates the electronic properties of the magnetite

Bioinspired nanofilament coatings for scale reduction on steel

• Siad Dahir Ali,
• Mette Heidemann Rasmussen,
• Jacopo Catalano,
• Christian Husum Frederiksen and
• Tobias Weidner

Beilstein J. Nanotechnol. 2025, 16, 25–34, doi:10.3762/bjnano.16.3

• moisture control and water interaction [1][2]. The structure and chemistry of insect skin are finely tuned to navigate these challenges, showcasing a sophisticated natural adaptation to efficiently repel water [3]. Springtails have mastered this capability using micro- and nanostructured skin surfaces

• in Figure 4A shows no damage of ablation of the structure. This is also supported by the EDX analysis, which shows that the composition is not changed within the error margins as the amount of oxygen and silicone remains constant in Figure 4B. The water contact angle (Figure 4C) is reduced a bit from

• surface hydrophobic [5]. (E) SNFs consist of silicone structure, which polymerize and grow on the surface. (F) SNF coating on steel mimics the multiscale springtail structuring. The coating decorates the surface with a water-repelling wire-like structure, which has been shown to be super-hydrophobic when

Orientation-dependent photonic bandgaps in gold-dust weevil scales and their titania bioreplicates

• Norma Salvadores Farran,
• Limin Wang,
• Primoz Pirih and
• Bodo D. Wilts

Beilstein J. Nanotechnol. 2025, 16, 1–10, doi:10.3762/bjnano.16.1

• volumes with differing refractive indices. The diamond TPMS structure is special as it provides optimal diffraction efficiency and can form photonic bandgaps even with lower refractive index contrasts (i.e., with refractive index contrasts above 2.1) [15][17]. This makes these structures rather

• . The domains in lattice orientation {100} exhibited polarization conversion. The structure inferred from optical measurements was confirmed using conventional and focused ion beam scanning electron microscopy (FIB-SEM). By averaging the reciprocal space images obtained from different lattice

• structure of the scales The body and the elytra of the gold-dust weevil Hypomeces squamosus are covered with iridescent scales (Figure 1). The scales on the wings and body appear mostly greenish, while the scales on the legs are more bluish (Figure 1a). The elytral scales are flat, about 70 μm long and

Mechanistic insights into endosomal escape by sodium oleate-modified liposomes

• Ebrahim Sadaqa,
• Satrialdi,
• Fransiska Kurniawan and
• Diky Mudhakir

Beilstein J. Nanotechnol. 2024, 15, 1667–1685, doi:10.3762/bjnano.15.131

• S1, reveals that a crucial aspect of AUR’s interaction with the endosomal membrane is the necessity of protonation under acidic conditions. Specifically, at pH 5, protonation of the aspartic and glutamic acid residues in AUR’s structure is vital for effective membrane interaction. This protonation

• rapid and deep integration reflects its potent ability to disrupt membrane structure, which likely leads to increased permeability. In contrast, AUR’s interaction is more controlled and surface-oriented and significantly influenced by its protonation state at acidic pH. The protonation-dependent

• membrane structure and dynamics. In contrast, the density profile for AUR (Figure 6c) shows a peak near the water–membrane interface, indicating a more superficial insertion compared to OLA. AUR’s density decreases significantly toward the bilayer center, highlighting its preference for interacting with