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Search for "alendronate" in Full Text gives 5 result(s) in Beilstein Journal of Nanotechnology.
Classification and application of metal-based nanoantioxidants in medicine and healthcare
Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36
- capability and were used to decrease the level of proinflammatory cytokines, including TNF-α and IL-6, at the inflammatory sites. As another example, an alendronate-coated nanoceria (CeAL) nanozyme was reported by Zhou et al. for both ROS and RNS scavenging [107]. Other RNS scavenging nanomaterials such as
Recent progress in cancer cell membrane-based nanoparticles for biomedical applications
Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24
- procedure for rats. (b) MRI visualization of the infarcted regions. Adapted with permission from [26]. Copyright 2021 American Chemical Society. This content is not subject to CC BY 4.0. Distribution of K7M2 cell membrane-coated hollow manganese dioxide nanoparticles loaded with alendronate and the
The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors
Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31
- with higher turnover rates [33]. The authors used alendronate as a surface-exposed ligand for directing bortezomib-loaded nanoparticles consisting of poly(ᴅ,ʟ-lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) to the bone microenvironment, which resulted in a 9.6-fold increase of bone
- localization of the functionalized nanoparticles relative to the non-functionalized nanoparticles. Additionally, the loaded PLGA–PEG–alendronate nanoparticles demonstrated satisfactory results in myeloma growth inhibition and overall survival of the murine models. Considering the toxicity of bortezomib
- the improvement of the overall therapeutic efficacy. A targeted NDDS for the co-delivery of ponatinib and SAR302503 (selective JAK2 inhibitor) for efficient CML treatment was developed by Mu and co-workers [47]. The authors employed alendronate-decorated PLA–PEG micelles for BM targeting. Both
Advanced hybrid nanomaterials
Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247
- is simultaneously employed as a contrast agent in magnetic resonance imaging (MRI) and for local heating therapy using magnetic particle hyperthermia [33]. In vitro hyperthermia tests showed efficiency in inoculating mouse breast cancer cells. Another study reports the use of alendronate-coated gold
- nanoparticles [34]. The resulting gold–alendronate nanoplatform combines antitumor activity through drug delivery and photothermal therapy, as illustrated in vitro on the inhibition of prostate cancer cells. In the field of hybrid coordination networks, new lanthanide-based networks synthesized by a solvo
Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment
Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273
- with the same molecule used as reductant, coating and therapeutic agent has been developed in a one-pot, one-phase process using alendronate, a drug from the bisphosphonate family known for its antitumor effects. In addition, the core made of gold nanoparticles (NPs) brings thermal functionalities
- under irradiation within the first biological window (650–900 nm). The Au@alendronate nanoplatform thus provided a combined antitumor activity through drug delivery and photothermal therapy. Au@alendronate NPs inhibited in vitro the proliferation of prostate cancer cells (PC3) in a dose-dependent manner
- , with an IC50 value of 100 µM. Under NIR irradiation a temperature increase was observed leading to a reduction of the IC50 value to 1 µM, with total tumor cell death at 100 µM. Keywords: alendronate; bisphosphonate; cancer treatment; gold nanoparticles; photothermia; Findings Bisphosphonates (BPs
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