Gold nanoparticle-decorated reduced graphene oxide as a highly effective catalyst for the selective α,β-dehydrogenation of N-alkyl-4-piperidones

• Brenda Flore Kenyim,
• Mihir Tzalis,
• Marilyn Kaul,
• Robert Oestreich,
• Aysenur Limon,
• Chancellin Pecheu Nkepdep and
• Christoph Janiak

Beilstein J. Nanotechnol. 2026, 17, 218–238, doi:10.3762/bjnano.17.15

• on the oxidation for tertiary amines and cyclic ketones. This trend is clearly illustrated in our own experiments on the ODH of N-benzyl-4-piperidone to N-benzyl-2,3-dihydropyridin-4(1H)-one (Table 2). At high catalyst loading (70 mg, 0.06 mol Au/mol piperidone), we observe lower conversion (25%) and

From shield to spear: Charge-reversible nanocarriers in overcoming cancer therapy barriers

• Madhuri Yeduvaka,
• Pooja Mittal,
• Ameer Boyalakuntla,
• Usman Bee Shaik,
• Himanshu Sharma,
• Thakur Gurjeet Singh,
• Siva Nageswara Rao Gajula and
• Lakshmi Vineela Nalla

Beilstein J. Nanotechnol. 2026, 17, 159–175, doi:10.3762/bjnano.17.10

• effective tumour penetration and notable reduction in MCF-7 tumours, with excellent biosafety in vivo [83]. 3.4 Improved cellular uptake Upon exposure to mildly acidic conditions of the tumour microenvironment (around pH 6.5–6.8), ionizable groups such as amines, imidazoles, or carboxyl-based moieties, CRNs

Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer

• Raissa Rodrigues Camelo,
• Vivianne Cortez Sombra Vandesmet,
• Octavio Vital Baccallini,
• José de Brito Vieira Neto,
• Thais da Silva Moreira,
• Luzia Kalyne Almeida Moreira Leal,
• Claudia Pessoa,
• Daniel Giuliano Cerri,
• Maria Vitória Lopes Badra Bentley,
• Josimar O. Eloy,
• Ivanildo José da Silva Júnior and
• Raquel Petrilli

Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7

• for the nanoparticle stability to avoid aggregation. The results can be justified by the neutral pH in which these liposomes are dispersed, since in a more acidic medium, it is expected that the amines, present in the lipids, are protonated, decreasing the zeta potential [49]. The DL% rates of the

Stereodiscrimination of guests in chiral organosilica aerogels studied by ESR spectroscopy

• Sebastian Polarz,
• Yasar Krysiak,
• Martin Wessig and
• Florian Kuhlmann

Beilstein J. Nanotechnol. 2025, 16, 2034–2054, doi:10.3762/bjnano.16.140

• ). One sees in Figure 13b that already for x > 0.05, the distance between the TEMPO units is around 1.4 nm. One may assume that a larger number of amines/x does not necessarily lead to a higher degree of functionalization in the post-functionalization step. The introduction of phenyl spacers in the oSIL

Cross-reactivities in conjugation reactions involving iron oxide nanoparticles

• Shoronia N. Cross,
• Katalin V. Korpany,
• Hanine Zakaria and
• Amy Szuchmacher Blum

Beilstein J. Nanotechnol. 2025, 16, 1504–1521, doi:10.3762/bjnano.16.106

• . Through the judicious use of controls, we demonstrate significant cross-reactivities of amines, thiols, maleimides, and common disulfide reducing agents with surface Fe of IONPs and show how these unwanted interactions can produce false positive results. Without proper controls, these can lead to

• )carbodiimide (EDC) coupling [5] and “click” chemistry reactions [6] have proven to be effective tools in the synthesis of novel functional materials. Carbodiimide coupling is an invaluable tool for the coupling of carboxylic acids to amines, through amide bond formation. The combination of EDC and N

• surface chemistries, these considerations are especially important. The reactivity of the iron oxide surface itself is often neglected, but it should be noted that the use of thiols [43][44][45][46] and amines [47][48] as anchoring groups for IONP ligands has been reported in the literature, so it is

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• , such as primary amines and sulfhydryl groups on proteins or other biomolecules. The reactive chemical group is the most important property of a cross-linker. The reactive group establishes the method and mechanism for polymer modification [43][45]. Harsh conditions such as low pH and high temperature

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

• tris(propylene) amines that facilitate nucleotide escape from the endosomes through a “proton sponge” effect, whereas primary amines are found in the periphery, which enable further particle functionalisation and effective complexation with nucleic acids [131]. Hollins et al. analysed the efficacy of

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

• synthesizing amine-functionalized MOFs. The uncoordinated and electron-rich nitrogen atoms in amines are ‘CO2-philic’ [33][35] and provide active adsorption sites for CO2 through Lewis acid–base interaction between CO2 and amines [67]. As illustrated in Figure 2d, adsorptive selectivity can also result from

• -free MMM as illustrated in Figure 7a. In another study, Khosravi et al. [33] functionalized HKUST-1 with amines to improve adhesion with a Pebax® 1657 polymer matrix through hydrogen bonding, illustrated in Figure 7c. Differential scanning calorimetry showed an increase in Tg of the MMM, indicating

Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• containing secondary metabolites that act as reducing and stabilizing agents. Among these metabolites, alkanes, aromatics, phenols, ethers, amines, and amides stand out for their role in the reduction, stabilization, and capping of silver nanoparticles [11][16][17][18][19]. Compounds of natural origin are

• evaluated as potential reducing agents in the biosynthesis of AgNPs were the secondary amines, aromatic primary amines, carboxylates, amides, alkenes, and aromatic compounds. Roni and collaborators prepared AgNPs from red algae [52]. An aqueous extract of H. musciformis was obtained (10 g of seaweed leaves

• found were amino acid residues, aromatic rings, geminal methyls, ether linkages, flavones, terpenoids, aliphatic amines, and alcohols/phenols. AgNPs were synthesized from an extract of the brown alga S. natans [53]. The extract was obtained via hot Soxhlet extraction of crushed leaves (40 °C) using

Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• , suggesting that the ND coating prevented the removal of wear debris from coated implants. The complex relation between NDs and macrophage activity can be further tuned by functionalization with short molecules as reported by Pentecost and co-workers [90], who used small amines to tune the inflammatory

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• sublethal doses can cause alterations in parasite tegument [85]. Bee venom comprises various pharmacologically active components, including melittin (constituting more than 50% of total proteins) and a mixture of enzymes, cell-lytic peptides, proteases, and bioactive amines [86]. This mixture has

Metal-organic framework-based nanomaterials for CO₂ storage: A review

• Ha Huu Do,
• Iqra Rabani and
• Hai Bang Truong

Beilstein J. Nanotechnol. 2023, 14, 964–970, doi:10.3762/bjnano.14.79

• frameworks (MOFs) [11][12][13]. Notably, MOFs constructed from metal ions and organic linkers are expected to be alternative materials to the organic alcohol amines in CCS [14]. These nanosized materials posess unique properties such as ultrahigh surface area, tunable pore size, open metal sites (OMSs), and

• . In a recent study, Gaikwad et al. modified MOF-177 nanoparticles using three different amines to enhance the amount of absorbed CO2 [37]. The optimally functionalized MOF-177, employing tetraethylenepentamine (TEPA), exhibited a remarkably higher amount of absorbed CO2 than bare MOF-177 under the

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• the reduction of disulfide bonds. Thiols, also called sulfhydryls, in the cysteine side chain are slightly less abundant than primary amines; therefore, the coupling by thiol groups is more selective [52]. Thiols in cysteines are linked by disulfide bonds (–S–S–) through an oxidation process where the

• proteins that do not have free thiol groups, such groups can be generated either by reducing the disulfide bonds (DTT and BME) or by introducing cysteine residues (Traut’s reagent and N-succinimidyl S-acetylthioacetate) at different positions. The reaction with primary amines or the reduction of disulfide

• bonds of the antibodies form free thiol groups. The free thiol groups of the antibody can be linked to the primary amines on NP surfaces using SMCC, sulfo-SMCC, and their analogues via maleimide coupling (Figure 4b). These crosslinkers react specifically with thiol groups at pH 6.5 to 7.5 and form

Structural, optical, and bioimaging characterization of carbon quantum dots solvothermally synthesized from o-phenylenediamine

• Zoran M. Marković,
• Milica D. Budimir,
• Martin Danko,
• Dušan D. Milivojević,
• Pavel Kubat,
• Danica Z. Zmejkoski,
• Vladimir B. Pavlović,
• Marija M. Mojsin,
• Milena J. Stevanović and
• Biljana M. Todorović Marković

Beilstein J. Nanotechnol. 2023, 14, 165–174, doi:10.3762/bjnano.14.17

• amines such as 2-ethylenediamine, poly(ethyleneamine), or trimethylamine, enhances the affinity of CQDs to biological structures whereas incorporation of nitrogen atoms in the honeycomb structure of CQDs contributes to a reduction of photobleaching [7]. Tepliakov et al. reported that CQDs can be treated

• assigned to N–H stretching vibrations of aliphatic primary amines whereas the peaks at 2880 and 2943 cm−1 originate from C–H stretching vibrations. A peak at 1759 cm−1 stems from C=O stretching vibrations (carboxylic acid) whereas the peaks at 1696 and 1593 cm−1 could be assigned to C=N stretching and N–H

Two-step single-reactor synthesis of oleic acid- or undecylenic acid-stabilized magnetic nanoparticles by thermal decomposition

• Mykhailo Nahorniak,
• Pamela Pasetto,
• Jean-Marc Greneche,
• Volodymyr Samaryk,
• Sandy Auguste,
• Anthony Rousseau,
• Nataliya Nosova and
• Serhii Varvarenko

Beilstein J. Nanotechnol. 2023, 14, 11–22, doi:10.3762/bjnano.14.2

• low stability (i.e., acetate, pentacarbonyl, acetylacetonate) in high-boiling-point solvents in the presence of stabilizing agents (e.g., fatty acids, higher amines, alcohols) or their mixtures [13][14][15]. Although thermal decomposition is a relatively simple method, minor modifications of the

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

• Alexandru-Milentie Hada,
• Nina Burduja,
• Marco Abbate,
• Claudio Stagno,
• Guy Caljon,
• Louis Maes,
• Nicola Micale,
• Massimiliano Cordaro,
• Angela Scala,
• Antonino Mazzaglia and
• Anna Piperno

Beilstein J. Nanotechnol. 2022, 13, 1361–1369, doi:10.3762/bjnano.13.112

• ability of the β-cyclodextrin polymer (PolyCD) to act as a symbiont of both MNPs and BMNPs [14]. Specifically, functional groups of PolyCD (i.e., amines, primary and secondary alcohols, and hemiacetals) are involved in the direct reduction of gold ions to Au NPs (Figure 1). PolyCD-capped Au NPs showed an

Design of surface nanostructures for chirality sensing based on quartz crystal microbalance

• Yinglin Ma,
• Xiangyun Xiao and
• Qingmin Ji

Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100

• the complexation process of various chiral calix[4]arenes derivatives with gas-phase R/S-1-phenethylamine [78]. They proved that due to the acid–base interaction, only derivatives with acid could bind well with chiral amines. The other derivatives with esters, amides, and alcohols showed low

• promoted the combination of S-1-phenethylamine, while the ortho-position may combine with R-1-phenethylamine. The QCM results were consistent with the data from 1H NMR spectroscopy. Moreover, the QCM method may also allow for the detection of weak interactions of amides and esters with amines and a slight

Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading

• Agnes-Valencia Weiss,
• Daniel Schorr,
• Julia K. Metz,
• Metin Yildirim,
• Saeed Ahmad Khan and
• Marc Schneider

Beilstein J. Nanotechnol. 2022, 13, 778–787, doi:10.3762/bjnano.13.68

• to quantify the degree of crosslinking by determining free lysine in the particles. Colorimetric determination with trinitrobenzenesulfonic acid (TNBS) is a common method [26]. Under alkaline conditions, the primary amines and TNBS react to trinitrophenyl derivatives and sulfite. The formed compound

• can be quantitatively measured by UV–vis spectrometry at a wavelength of λ = 349 nm related to the number of primary amines present in the equal amount of uncrosslinked gelatin. In brief, the method was as follows: 10 to 12 mg of freeze-dried particles was resuspended in 1 mL of a 4% NaHCO3 solution

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• the backbone, acidification of amines, hydrogen bonding, exciplex formation, amine oxidation, and solvent-induced aggregation were reported as factors that amplify the weak luminescence of PEI and amine-containing dendrimers [15][16][17][18][20][24]. The luminescence of these materials is especially

• amines during the synthesis of SPION@bPEI is responsible for the enhanced bPEI luminescence. It is further enhanced with the immobilization of bPEI on SPION crystals and post-synthetic acidification of the particles, which also increased the rigidity. These nanoparticles have a small hydrodynamic size

• of Erb to nanoparticles consumed some amines, and the antibody contains anionic functionalities as well. The Erb conjugation decreased the luminescence intensity of SPION@bPEI by approx. 30%, but PIC loading (Figure 2b) or DNA loading did not change the luminescence intensity any further (Supporting

Sputtering onto liquids: a critical review

• Anastasiya Sergievskaya,
• Adrien Chauvin and
• Stephanos Konstantinidis

Beilstein J. Nanotechnol. 2022, 13, 10–53, doi:10.3762/bjnano.13.2

• metal precursor, usually a salt such as HAuCl4, is chemically reduced by a (ii) reagent (e.g., sodium citrate, sodium borohydrate, ascorbic acid, glucose, hydrazine, or various amines) in the presence of a (iii) stabilizing agent (e.g., organic thiols, amines, acids, or various surfactants, i.e

pH-driven enhancement of anti-tubercular drug loading on iron oxide nanoparticles for drug delivery in macrophages

• Karishma Berta Cotta,
• Sarika Mehra and
• Rajdip Bandyopadhyaya

Beilstein J. Nanotechnol. 2021, 12, 1127–1139, doi:10.3762/bjnano.12.84

• of Fe–O stretching, from the IONPs, along with characteristic peaks of amines. C–F, N–H bending of quinolones and N–H stretching of piperazinyl were observed at 550–650, 1000–1050, 1650 and 3300–3500 cm−1, indicating the presence of NOR (Figure 3d) [36][37][38]. It was noted that the N–H stretching

Revealing the formation mechanism and band gap tuning of Sb₂S₃ nanoparticles

• Maximilian Joschko,
• Franck Yvan Fotue Wafo,
• Christina Malsi,
• Danilo Kisić,
• Ivana Validžić and
• Christina Graf

Beilstein J. Nanotechnol. 2021, 12, 1021–1033, doi:10.3762/bjnano.12.76

•  6b, and Figures S6 and S7 in Supporting Information File 1). The nonstoichiometric Sb/S ratio in the early reaction stage was probably due to the oleylamine used in the synthesis. Several authors have already described that hydrolysis of antimony in fatty amines can lead to the formation of Sb2O3 [33

A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures

• Sina Kaabipour and
• Shohreh Hemmati

Beilstein J. Nanotechnol. 2021, 12, 102–136, doi:10.3762/bjnano.12.9

Straightforward synthesis of gold nanoparticles by adding water to an engineered small dendrimer

• Sébastien Gottis,
• Régis Laurent,
• Vincent Collière and
• Anne-Marie Caminade

Beilstein J. Nanotechnol. 2020, 11, 1110–1118, doi:10.3762/bjnano.11.95

• fibers stabilized by amines (AuI, ca. 3.25 Å) [10], but slightly longer than in the case of gold particles in silica glass and gold foil (2.84 Å) [61] or in bulk gold (2.88427 Å) [10]. The dependence between the gold nanoparticle shape and the conditions in which they were generated is the subject of a

Applications of superparamagnetic iron oxide nanoparticles in drug and therapeutic delivery, and biotechnological advancements

• Maria Suciu,
• Corina M. Ionescu,
• Alexandra Ciorita,
• Septimiu C. Tripon,
• Dragos Nica,
• Hani Al-Salami and
• Lucian Barbu-Tudoran

Beilstein J. Nanotechnol. 2020, 11, 1092–1109, doi:10.3762/bjnano.11.94

• -coated SPIONs are biocompatible, but a higher number of amines in the coating is not compatible with the animal metabolism [84]. Even so, Strehl et al. [26] concluded in their paper that PVA-coated SPIONs with amines had no toxic effect on immune cells. Instead, they actually determined a viability