Antitumor magnetic hyperthermia induced by RGD-functionalized Fe₃O₄ nanoparticles, in an experimental model of colorectal liver metastases

• Oihane K. Arriortua,
• Eneko Garaio,
• Borja Herrero de la Parte,
• Maite Insausti,
• Luis Lezama,
• Fernando Plazaola,
• Jose Angel García,
• Jesús M. Aizpurua,
• Maialen Sagartzazu,
• Mireia Irazola,
• Nestor Etxebarria,
• Ignacio García-Alonso,
• Alberto Saiz-López and
• José Javier Echevarria-Uraga

Beilstein J. Nanotechnol. 2016, 7, 1532–1542, doi:10.3762/bjnano.7.147

• motifs. These molecules could also be easily modified with functional groups, from azides or amines to other amino acids and fluorophores that give them different specificities [28]. One of the procedures to bind RGD peptides due to its unique features such as high aqueous competency, efficiency and

An efficient recyclable magnetic material for the selective removal of organic pollutants

• Clément Monteil,
• Nathalie Bar,
• Agnès Bee and
• Didier Villemin

Beilstein J. Nanotechnol. 2016, 7, 1447–1453, doi:10.3762/bjnano.7.136

• of NP regardless of the pH value, especially in very basic medium, which is not the case for plain PEI [23]. The phosphonated groups are introduced on PEI through the modification of primary and secondary amines according to the Moedritzer and Irani synthesis [24]. In a previous work we described the

• synthesis, the coating of maghemite and a characterization of the physicochemical properties of the material [20][22]. As illustrated in Figure 1, PEIP can be customized to contain more or less phosphonated groups, by varying the percentage of amines modified (P%). Between pH 3 and 10, the zeta potential is

Rigid multipodal platforms for metal surfaces

• Michal Valášek,
• Marcin Lindner and
• Marcel Mayor

Beilstein J. Nanotechnol. 2016, 7, 374–405, doi:10.3762/bjnano.7.34

• -defined spatial arrangement of the tailor-made functional molecules on a solid surface is of paramount importance in the design of single-molecule devices. So far, many anchoring groups such as thiols (–SH) [26][27][28][29], amines (–NH2) [15][26][30], phosphines [31], pyridines [9][32][33][34][35

Green and energy-efficient methods for the production of metallic nanoparticles

• Mitra Naghdi,
• Mehrdad Taheran,
• Satinder K. Brar,
• M. Verma,
• R. Y. Surampalli and
• J. R. Valero

Beilstein J. Nanotechnol. 2015, 6, 2354–2376, doi:10.3762/bjnano.6.243

• aggregation due to lower availability of amines and the reduced cross-linking ability. The average sizes of Pt, Au, and Ag NPs were about 3.5, 23, and 7.5 nm respectively. According to their FTIR data, the amine and amide functionalities had the most interaction in CTS, while in CMC, the alcohol

Self-organization of gold nanoparticles on silanated surfaces

• Htet H. Kyaw,
• Salim H. Al-Harthi,
• Azzouz Sellai and
• Joydeep Dutta

Beilstein J. Nanotechnol. 2015, 6, 2345–2353, doi:10.3762/bjnano.6.242

• signals clearly point to the presence of APTES (C9H23NO3Si) on the glass substrates as it is confirmed with the presence of N 1s peak (Figure 1c). A peak arising at 399.9 eV can be attributed to amine groups while the peak at 401.9 eV can be assigned to the protonated amines (Figure 1c) [24]. Self

Surfactant-controlled composition and crystal structure of manganese(II) sulfide nanocrystals prepared by solvothermal synthesis

• Elena Capetti,
• Anna M. Ferretti,
• Vladimiro Dal Santo and
• Alessandro Ponti

Beilstein J. Nanotechnol. 2015, 6, 2319–2329, doi:10.3762/bjnano.6.238

• morphological parameters. It is clear from Table 1 that amines direct the reaction toward γ-MnS NCs while all other free surfactants (or the absence thereof) lead to α-MnS NCs. This γ-directing effect, independent of the amine chain length and degree of saturation, seems to be related to the basicity of amines

• , which is highest within our surfactant set [38]. Nucleophilicity can be excluded since alkyl amines are less nucleophilic than sulfur compounds [39]. Similarly, the ability to undergo condensation reaction with carboxylic acids can be excluded since oleyl alcohol could react with stearic acid to give

• precursor molecule To understand the role that the stearate ligand presents in the precursor in the above reactions leading to γ-MnS NCs, we carried out synthetic experiments similar to those described in the previous subsection, employing Mn2(CO)10 as a precursor and restricting ourselves to amines as a

Green synthesis, characterization and catalytic activity of natural bentonite-supported copper nanoparticles for the solvent-free synthesis of 1-substituted 1H-1,2,3,4-tetrazoles and reduction of 4-nitrophenol

• Akbar Rostami-Vartooni,
• Mohammad Alizadeh and
• Mojtaba Bagherzadeh

Beilstein J. Nanotechnol. 2015, 6, 2300–2309, doi:10.3762/bjnano.6.236

• azide/triethyl orthoformate, in the presence of Cu NPs/bentonite (0.05 g) under solvent-free conditions at 120 °C. A series of primary aromatic amines were converted into the corresponding 1-substituted tetrazoles with sodium azide and triethyl orthoformate using Cu NPs/bentonite in high yields under

• thermal and solvent-free conditions (Table 2). The influence of various substituents in different ortho, meta or para positions on the type of products were examined. Amines containing both electron-releasing and electron-withdrawing groups underwent the conversion in good to excellent yield. The Cu NPs

• /bentonite by reaction between sodium azide, primary amines and triethyl orthoformate at 120 °C.a Acknowledgments We gratefully acknowledge the Iranian Nano Council and the University of Qom for the support of this work.

Conformational switching of ethano-bridged Cu,H₂-bis-porphyrin induced by aromatic amines

• Simona Bettini,
• Emanuela Maglie,
• Rosanna Pagano,
• Victor Borovkov,
• Yoshihisa Inoue,
• Ludovico Valli and
• Gabriele Giancane

Beilstein J. Nanotechnol. 2015, 6, 2154–2160, doi:10.3762/bjnano.6.221

• Langmuir trough. The bis-porphyrin derivative, floating film was characterized by reflection spectroscopy and the surface pressure of the floating film was studied as a function of the mean area per molecule. When aromatic amines are dissolved in the subphase, an evident interaction between the bis

• -porphyrin host and the aromatic amine guest is observed. A clear-cut variation of the profile of surface pressure vs area per molecule curve is observed. Reflection spectroscopy highlights that the aromatic amines dissolved in the subphase are able to induce the syn-to-anti conformational switching in the

• in aqueous solution. The high selectivity of the SPR sensing device has been verified by checking the spectral response of the active layer towards other analytes dissolved in the aqueous solutions. Keywords: aromatic amines; bis-porphyrin; conformational switching; Langmuir film; surface plasmon

Conductance through single biphenyl molecules: symmetric and asymmetric coupling to electrodes

• Karthiga Kanthasamy and
• Herbert Pfnür

Beilstein J. Nanotechnol. 2015, 6, 1690–1697, doi:10.3762/bjnano.6.171

• found to be a promising group with high stability and high surface mobility [16][17][18][19][20], but studies have also been carried out for amines (NH2), carboxyls (COOH), dimethylphosphines (PMe2) and selenols (SeH) [21][22][23][24]. Mostly the experiments have been carried out with symmetric

DNA–melamine hybrid molecules: from self-assembly to nanostructures

• Rina Kumari,
• Shib Shankar Banerjee,
• Anil K. Bhowmick and
• Prolay Das

Beilstein J. Nanotechnol. 2015, 6, 1432–1438, doi:10.3762/bjnano.6.148

• reaction between aliphatic primary amine moieties and a terminal phosphate group of DNA was previously reported [27][28]. We optimized the reaction for the coupling of the aromatic amines of melamine with the 5’-terminal phosphate groups of two self-complementary ssDNA molecules (24 bases long, Supporting

• 5’-phosphorimidazolide intermediate further reacts in situ with the primary aromatic amines of the melamine to give the desired product. In this study, an excess of ssDNA (10×) was used so that the probability of multiple DNA strands conjoined to a melamine molecule is increased. The solution-phase

Peptide-equipped tobacco mosaic virus templates for selective and controllable biomineral deposition

• Klara Altintoprak,
• Axel Seidenstücker,
• Alexander Welle,
• Sabine Eiben,
• Petia Atanasova,
• Nina Stitz,
• Alfred Plettl,
• Joachim Bill,
• Hartmut Gliemann,
• Holger Jeske,
• Dirk Rothenstein,
• Fania Geiger and
• Christina Wege

Beilstein J. Nanotechnol. 2015, 6, 1399–1412, doi:10.3762/bjnano.6.145

• ) ester-mediated crosslinking with lysine primary amines, yielding amide bonds. (c) Mineralization-affecting peptides were conjugated to the maleimide-activated SM(PEG)4 linker portion via the sulfhydryl groups of their terminal cysteine residues, yielding stable thioether linkages. The resulting

Electrical characterization of single molecule and Langmuir–Blodgett monomolecular films of a pyridine-terminated oligo(phenylene-ethynylene) derivative

• Henrry M. Osorio,
• Santiago Martín,
• María Carmen López,
• Santiago Marqués-González,
• Simon J. Higgins,
• Richard J. Nichols,
• Paul J. Low and
• Pilar Cea

Beilstein J. Nanotechnol. 2015, 6, 1145–1157, doi:10.3762/bjnano.6.116

• pseudolinear (ohmic) region of the I–V curves. This value is higher than that of the conductance values of LB films of phenylene-ethynylene derivatives contacted by amines, thiols, carboxylate, trimethylsilylethynyl or acetylide groups. In addition, the single molecule I–V curve of 1 determined using the I(s

• groups have been studied in an attempt to find an ideal combination of molecular backbone, contact and metallic electrodes. Particularly prominent examples of metal–molecule contacting groups include thiols [46][47], selenols [48][49], dithiocarbamates [50][51], carbodithioates [52], amines [53][54

Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability

• Ognen Pop-Georgievski,
• Dana Kubies,
• Josef Zemek,
• Neda Neykova,
• Roman Demianchuk,
• Eliška Mázl Chánová,
• Miroslav Šlouf,
• Milan Houska and
• František Rypáček

Beilstein J. Nanotechnol. 2015, 6, 617–631, doi:10.3762/bjnano.6.63

• broadening of the dominate IR contributions toward the initially observed main peaks of APTES "monomer". This may be a source of the hydrolytical layer instability. In a water environment, the primary amines present in the network can intra- or inter- molecularly coordinate to a silicon center and catalyze

• arising from sp3 carbon (C–C and C–H functionalities), at 285.9 ± 0.1 eV arising from the C–N species of amines and at 286.6 ± 0.2 eV arising from the C–O contribution of hydroxy groups present in neridronate, the non-hydrolyzed ethoxy groups of APTES and catechols of poly(dopamine). The spectrum of APTES

• the scrubbing effect of amines on CO2 from air [57]. The topography and homogeneity of the resulting anchor layers on titanium substrates was monitored via AFM. The corresponding images are presented in Figure 4. The AFM data clearly evidence the functionalization of the flat titanium surfaces with

Tailoring the ligand shell for the control of cellular uptake and optical properties of nanocrystals

• Johannes Ostermann,
• Christian Schmidtke,
• Christopher Wolter,
• Jan-Philip Merkl,
• Hauke Kloust and
• Horst Weller

Beilstein J. Nanotechnol. 2015, 6, 232–242, doi:10.3762/bjnano.6.22

• based on specific chemical groups like amines, carboxyl and hydroxyl functions [31]. Functional groups are not only useful for typical coupling strategies of biomolecules, but also for the determination of the surface properties of the final nanocontainers. Differently charged particles show different

Chemoselective silicification of synthetic peptides and polyamines

• Maryna Abacilar,
• Fabian Daus and
• Armin Geyer

Beilstein J. Nanotechnol. 2015, 6, 103–110, doi:10.3762/bjnano.6.10

• with the less capable Si precipitator in the presence of the better precipitator? Is there a measurable cooperativity between peptides and amines? Silica precipitation experiments are time consuming and error-prone because many actions are needed to separate the precipitate of amorphous silica, to dry

• precipitate silica (Figure 2). Three amines with increasing number of nitrogen atoms, a basic peptide, and a toxin [14] that is not involved in biomineralization but stands exemplary for other amines capable of silica precipitation. Synthetic methods Figure 3 shows the synthetic strategies used to access the

• molecules 2–5. CTC resin [chloro-(2'-chlorotrityl)polystyrene resin] served as a solid support and was functionalized directly with different amines [14]. The nucleophilicity of one nitrogen of 1,3-propylenediamine was annihilated by tritylation with CTC resin (Figure 3 upper row) while the other peripheral

The fate of a designed protein corona on nanoparticles in vitro and in vivo

• Denise Bargheer,
• Julius Nielsen,
• Gabriella Gébel,
• Markus Heine,
• Sunhild C. Salmen,
• Roland Stauber,
• Horst Weller,
• Joerg Heeren and
• Peter Nielsen

Beilstein J. Nanotechnol. 2015, 6, 36–46, doi:10.3762/bjnano.6.5

• surface was modified by PEGylation with mono- or bifunctional poly(ethylene oxide)amines (PEG). Using 125I-labeled test proteins (transferrin, albumin), the binding and exchange of corona proteins was studied first in vitro. Incubation with 125I-transferrin showed that with increasing grade of PEGylation

Mammalian cell growth on gold nanoparticle-decorated substrates is influenced by the nanoparticle coating

• Christina Rosman,
• Sebastien Pierrat,
• Marco Tarantola,
• David Schneider,
• Eva Sunnick,
• Andreas Janshoff and
• Carsten Sönnichsen

Beilstein J. Nanotechnol. 2014, 5, 2479–2488, doi:10.3762/bjnano.5.257

• average, negatively charged. Electrostatic interaction with negatively charged COOH–PEG nanorods should therefore be repulsive, comparable to the bare glass substrates. In contrast, amines are known to interact with the negatively charged cell membrane. It is therefore likely that an anchoring of the

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

• Pauline Maffre,
• Stefan Brandholt,
• Karin Nienhaus,
• Li Shang,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2036–2047, doi:10.3762/bjnano.5.212

• , Table 2, Figure 3a) [22]. By reacting the amines on lysine side chains with succinic acid anhydride, the number of negatively charged carboxylic acid groups on the surface is increased. Succinylation is likely to reduce the charge density of the positively charged region on HSA that is responsible for

Electrostatic interplay: The interaction triangle of polyamines, silicic acid, and phosphate studied through turbidity measurements, silicomolybdic acid test, and ²⁹Si NMR spectroscopy

• Anne Jantschke,
• Katrin Spinde and
• Eike Brunner

Beilstein J. Nanotechnol. 2014, 5, 2026–2035, doi:10.3762/bjnano.5.211

• synthesis approaches. The present contribution deals with the influence of amines and polyamines upon the initial self-assembly processes taking place during polyamine-mediated silica formation in solution. The influence of phosphate upon these processes is studied. For this purpose, sodium metasilicate

• particular at elevated pH. Belton et al. [25] indeed observed an enhanced reaction rate for the silicic acid polycondensation reaction in the presence of different amines at pH 6.8 whereas Behrens et al. [50] did not observe such an effect at pH 5.5. Elucidation of this possible catalytic effect and its

• -containing solution A with different amines (solution B). Preparation of solution A without phosphate: Solution A was prepared by titration of a stock solution of sodium metasilicate (ca. 250 mM) to pH 6.8 or 5.5 with 2.5 M hydrochloric acid (see final concentrations in Table 2). Finally, the samples were

Donor–acceptor graphene-based hybrid materials facilitating photo-induced electron-transfer reactions

• Anastasios Stergiou,
• Georgia Pagona and
• Nikos Tagmatarchis

Beilstein J. Nanotechnol. 2014, 5, 1580–1589, doi:10.3762/bjnano.5.170

• approach, the covalent grafting of (2-aminoethoxy)(tri-tert-butyl)phthalocyanine zinc (ZnPc) to exfoliated graphene sheets via direct nucleophilic addition of primary amines was accomplished (Figure 5) [57]. The ZnPc–graphene hybrid material was extensively characterized by complementary spectroscopic

• anchored to exfoliated graphene [55]. Covalent grafting of (2-aminoethoxy)(tri-tert-butyl)phthalocyanine zinc to exfoliated graphene sheets via direct nucleophilic addition of primary amines [57]. Phthalocyanine–graphene hybrid material, prepared upon condensation of mono-OH-derivatized phthalocyanine with

Organic and inorganic–organic thin film structures by molecular layer deposition: A review

• Pia Sundberg and
• Maarit Karppinen

Beilstein J. Nanotechnol. 2014, 5, 1104–1136, doi:10.3762/bjnano.5.123

• divided by the organic precursor employed. The subchapters “Alcohols and phenols”, “Acids” and “Amines” contain all the different hybrid films made by using an organic precursor with hydroxyl, carboxyl or nitrogen atom functionality, respectively. It should be noted that some of precursors under “Alcohols

• measurements. Amines Two diamines, 1,4-diaminobenzene and ODA, have been used to fabricate inorganic–organic hybrid thin films by ALD/MLD (Table 13). The 1,4-diaminobenzene, i.e., an amine equivalent of HQ, was used together with TMA. The depositions were carried out in the temperature range of 200–400 °C. The

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• , which was mainly due to the covalent bonding of the peptide to the surface. FTIR confirmed that the layer was DGEA as several characteristic peaks for DGEA were represented in the ND-DGEA spectrum (Figure 3). Particularly, there were peaks due to C–N stretching in primary or secondary amines of amino

• the NDs and the free amines on the peptide. Next, the ND-DGEA+DOX system was prepared by physically adsorbing DOX to the already synthesized ND-DGEA conjugates. After successful adsorption, the peak absorbance in the DOX spectra in Figure 1b decreased to a value of approximately 100 µg by linear

Controlling mechanical properties of bio-inspired hydrogels by modulating nano-scale, inter-polymeric junctions

• Seonki Hong,
• Hyukjin Lee and
• Haeshin Lee

Beilstein J. Nanotechnol. 2014, 5, 887–894, doi:10.3762/bjnano.5.101

• ][8][9]. For insect cuticles, the quinone tanning (i.e., sclerotization) occurs via crosslinking of cuticular proteins in which primary amines, secondary amines, and phenols from the proteins react with N-acetylcatecholamines [9][10][11]. For squid beaks, the reaction between the imidazole of

• kDa) and 6Arm-PEG-NH-catechol (15 kDa) was performed by a simple one-step reductive amination between 3,4-dihydroxybenzaldehyde (DHBA) and linear or 6Arm-PEG-NH2 (Figure 1d and Figure 1e). Primary amines are difficult to be chemically tethered to PEG-catechol, because the typical reaction (i.e., EDC

• coupling) is the formation of an amide bond between the primary amine and the carboxyl group. Instead, we could easily generate secondary amines by using aldehyde chemistry, in other words reductive amination reaction, for the PEG-catechol to contain secondary amine groups. Secondary amines are also well

DNA origami deposition on native and passivated molybdenum disulfide substrates

• Xiaoning Zhang,
• Masudur Rahman,
• David Neff and
• Michael L. Norton

Beilstein J. Nanotechnol. 2014, 5, 501–506, doi:10.3762/bjnano.5.58

• 1-pyrenemethylamine molecule enables it to physisorb on to the MoS2 surface while the amine functionality enables the electrostatic tethering of the 1-pyrenemethylamine to the DNA, is consistent with the reported intercalation of pyrene into MoS2 [23] and the known use of amines to efficiently bind

Neutral and charged boron-doped fullerenes for CO₂ adsorption

• Suchitra W. de Silva,
• Aijun Du,
• Wijitha Senadeera and
• Yuantong Gu

Beilstein J. Nanotechnol. 2014, 5, 413–418, doi:10.3762/bjnano.5.49

• , fossil fuel combustion continues to be the main source of electricity while releasing 13 Gt of CO2 [1] to the atmosphere each year. Therefore CO2 capture and storage (CCS) technology is a promising solution to reduce atmospheric CO2 emissions [2]. Solvent absorption that is based on amines is the most