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Search for "antioxidant" in Full Text gives 52 result(s) in Beilstein Journal of Nanotechnology.
Rational design of block copolymer self-assemblies in photodynamic therapy
Beilstein J. Nanotechnol. 2020, 11, 180–212, doi:10.3762/bjnano.11.15
Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects
Beilstein J. Nanotechnol. 2019, 10, 2304–2328, doi:10.3762/bjnano.10.222
- represent 77%, 17% and 3% of the content of the dried extract from curcuma root, respectively [30][31]. CUR has shown anti-inflammatory, antirheumatic and antioxidant activities and it has been used in hepatic and other chronic diseases including diabetes [32]. Recently, the activity of CUR as an anticancer
Preservation of rutin nanosuspensions without the use of preservatives
Beilstein J. Nanotechnol. 2019, 10, 1902–1913, doi:10.3762/bjnano.10.185
- potential, antioxidant capacity and the microbial quality were determined and monitored over this period of time (Figure 1). Results and Discussion Production and characterization of nanosuspensions High-pressure homogenization yielded rutin nanosuspensions with a relatively broad size distribution, i.e
- preservative. In fact, Plantacare provides a very efficient stabilization mechanism, which is not significantly impaired by the addition of the preservative. This explains the slightly better physical stability than that of the preserved PLX-stabilized nanosuspensions. Antioxidant capacity The antioxidant
- capacity (AOC) was measured with the DPPH assay in which the IC50 value is determined. The IC50 value determines the amount of antioxidant needed to scavenge 50% of the free radical. Consequently, the smaller the IC50 value the higher is the antioxidant capacity. In this study, the IC50 values for the
Lipid nanostructures for antioxidant delivery: a comparative preformulation study
Beilstein J. Nanotechnol. 2019, 10, 1789–1801, doi:10.3762/bjnano.10.174
- Surgical Sciences, University of Ferrara, I-44121 Ferrara, Italy Department of Food and Nutrition, Kyung Hee University, Seoul, Korea 10.3762/bjnano.10.174 Abstract This investigation is a study of new lipid nanoparticles for cutaneous antioxidant delivery. Several molecules, such as α-tocopherol and
- retinoic acid, have been shown to improve skin condition and even counteract the effects of exogenous stress factors such as smoking on skin aging. This work describes the design and development of lipid nanoparticles containing antioxidant agents (α-tocopherol or retinoic acid) to protect human skin
- solid lipid nanoparticles, suggesting their suitability for antioxidant loading. Based on the preformulation study, tristearin-based nanostructured lipid carriers loaded with α-tocopherol were selected for ex vivo studies since they displayed superior physico-chemical properties as compared to the other
Nanoporous smartPearls for dermal application – Identification of optimal silica types and a scalable production process as prerequisites for marketed products
Beilstein J. Nanotechnol. 2019, 10, 1666–1678, doi:10.3762/bjnano.10.162
- addition, a scalable production process was demonstrated. The loading of the particles was performed by applying the immersion–evaporation method. The antioxidant rutin was used as a model active agent and ethanol was applied as the solvent. Various silica particles (Syloid®, Davisil®) differing in
Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles
Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108
- analysis. Magnetic measurements indicated that the polymer coating does not affect the superparamagnetic character of the iron oxide core. However, magnetic saturation decreased with increasing thickness of the polymer coating. The antioxidant properties of the nanoparticles were analyzed using a 2,2
- -diphenyl-1-picrylhydrazyl (DPPH) assay. Cellular uptake and intracellular antioxidant activity of the particles were evaluated by an iron assay and flow cytometry, respectively, using L-929 and LN-229 cells. Compared to the control, the phenolic modification significantly reduced intracellular reactive
- oxygen species (ROS) levels to 35–56%, which was associated with a 6–8-times higher cellular uptake in L-929 cells and a 21–31-times higher cellular uptake in LN-229 cells. In contrast, γ-Fe2O3@Hep particles induced a 3.8-times and 14.9-times higher cellular uptake without inducing antioxidant activity
The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model
Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91
- , namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathione S-transferase was conducted. A comparison at different intervals of time after the administration of a dose (5 mg/kg) of PEG-nGO was carried out. An increase in free radicals and
- ]. Raised intracellular levels of ROS cause oxidative stress in cells [40]. Aerobic organisms alleviate the damaging effects of ROS with antioxidant systems comprising enzymatic and non-enzymatic antioxidants [41]. Our research aims to determine the oxidative stress induced through the administration of PEG
- great amounts of PUFA, high levels of MDA indicate damaged cell membranes. MDA is commonly used as a marker for oxidative stress and the antioxidant status of the respective organ. It was also show that tissues of heart and kidneys are greatly influenced by PEG-nGO. A decreased amount of the antioxidant
Biomimetic synthesis of Ag-coated glasswing butterfly arrays as ultra-sensitive SERS substrates for efficient trace detection of pesticides
Beilstein J. Nanotechnol. 2019, 10, 578–588, doi:10.3762/bjnano.10.59
- a facile and low-cost approach to fabricate hierarchical SERS systems with high sensitivity, stability and good reproducibility. In this paper, with the aim to further improve the sensitivity and antioxidant properties as well as to achieve a high reproducibility of the substrates mentioned in our
Ceria/polymer nanocontainers for high-performance encapsulation of fluorophores
Beilstein J. Nanotechnol. 2019, 10, 522–530, doi:10.3762/bjnano.10.53
- excellent antioxidant properties, ideal for applications such as water-gas shift catalysis [40], combustion catalysis [41], oxygen ion conductors, and solid-oxide fuel cells [42]. Due to the valence and oxygen defect properties of cerium(IV) oxide, nanoparticles of this material are also used as efficient
Co-intercalated layered double hydroxides as thermal and photo-oxidation stabilizers for polypropylene
Beilstein J. Nanotechnol. 2018, 9, 2980–2988, doi:10.3762/bjnano.9.277
- ][17]. For example, the antioxidant Irganox 1425 (see Figure 1, abbreviated as MP-Ca) was intercalated into Ca2Al-LDH through coprecipitation of MP-Ca and Al(NO3)3 at pH 10, to yield MP-Ca2Al-LDH. Here, the MP-Ca was used the source of Ca for the host sheet and that of MP for the guest anions
- hindered amine light stabilizer (HALS) and a hindered phenolic antioxidant (MP) into the interlayer region of Ca2Al-LDHs with different molar ratios through coprecipitation. The concomitant intercalation of HALS and MP significantly enhances the thermal stability of the powders due to the host–guest
Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition
Beilstein J. Nanotechnol. 2018, 9, 530–544, doi:10.3762/bjnano.9.51
- antioxidant, anti-inflammatory, anticancer, antiviral and antibacterial activities [22]. Red chilli is another common spice the main pungent ingredient of which is capsaicin. It is used to alleviate neuropathic pain and itching in humans. Moreover, its anticancer properties have been reported in the
A nanocomplex of C60 fullerene with cisplatin: design, characterization and toxicity
Beilstein J. Nanotechnol. 2017, 8, 1494–1501, doi:10.3762/bjnano.8.149
- concentrations), exerting strong antioxidant properties due to their high activity as free radical acceptors [14][15]. Water-soluble pristine С60 fullerenes penetrate through plasma membranes and are located in the central part of tumor cells [16]. Thereby, C60 fullerenes can be used for treatment of cancer [17
Voltammetric determination of polyphenolic content in pomegranate juice using a poly(gallic acid)/multiwalled carbon nanotube modified electrode
Beilstein J. Nanotechnol. 2016, 7, 1104–1112, doi:10.3762/bjnano.7.103
- attributed to the oxidation of different polyphenolic compounds, including GA and CAT, as judged from a comparison of their voltammetric response. Thus, it can be concluded that the first wave may dominate the response of GA. Gallic acid is one of the most common references for evaluation of the antioxidant
Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms
Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57
- . This was accompanied by elevated levels of ROS, MDA, constitutive nitric oxide synthase (cNOS), induced nitric oxide synthase (iNOS), and nitric oxide (NO), and inhibited activities of SOD, CAT, ascorbate peroxidase (APX), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), and AChE
- , in the hippocampal area. Meanwhile, the ROS levels were enhanced, and the activities of antioxidant enzymes such as SOD, CAT, ascorbate peroxidase (Apx), and GSH-Px were inhibited. In addition, the ratios of AsA to DAsA and GSH to GSSG were decreased. These changes suggested that apoptosis and OS
Green and energy-efficient methods for the production of metallic nanoparticles
Beilstein J. Nanotechnol. 2015, 6, 2354–2376, doi:10.3762/bjnano.6.243
- preventive or protective properties with regard to human health. They are not essential for the human body to survive but they can act as antioxidant, enzyme stimulator, or antibacterial agent, and they can interfere with DNA to prevent the multiplication of cancer cells. Researchers found that several
Green synthesis, characterization and catalytic activity of natural bentonite-supported copper nanoparticles for the solvent-free synthesis of 1-substituted 1H-1,2,3,4-tetrazoles and reduction of 4-nitrophenol
Beilstein J. Nanotechnol. 2015, 6, 2300–2309, doi:10.3762/bjnano.6.236
- , the use of plants as a natural and biological source for biosynthesis of nanoparticles should be explored. Common thyme with the scientific name Thymus vulgaris is one of the plants indigenous to Iran which is valued for its antiseptic and antioxidant properties [19]. Thymol (1), carvacrol (2), p
Electrochemical behavior of polypyrrol/AuNP composites deposited by different electrochemical methods: sensing properties towards catechol
Beilstein J. Nanotechnol. 2015, 6, 2052–2061, doi:10.3762/bjnano.6.209
- detection of phenolic compounds, which are strong antioxidant reagents present in foods, with beneficial effects on human health [23]. As phenols are electroactive compounds, they can be detected by amperometric or voltammetric techniques using graphite or platinum electrodes [24][25][26]. In addition
- based on electrodeposited Ppy/AuNps for the detection of catechol (an antioxidant of interest in the food industry) and to evaluate the influence of the electrodeposition method in their performance. For this purpose Ppy/AuNp films doped with 1-decanesulfonic acid (DSA) were deposited using different
Fulleropeptide esters as potential self-assembled antioxidants
Beilstein J. Nanotechnol. 2015, 6, 1065–1071, doi:10.3762/bjnano.6.107
- delocalization of the π-electronic system over the C60 sphere, its antioxidant capacity remained high for all twelve derivatives. The compounds expressed up to two-fold and 5–12-fold better peroxide quenching capacity as compared to pristine C60 and standard antioxidant vitamin C, respectively. During
- precipitation and slow evaporation of the solvent, all compounds underwent spontaneous self-assembly giving ordered structures. The size and morphology of the resulting particles depend primarily on the sample concentration, and somewhat on the side chain structure. Keywords: antioxidant activity; cyclic
- , Keller et al. [18] reported the synthesis of fullerenedihydropyrrole cationic peptides, which did not show antibacterial activity. Neuroprotective and antioxidant properties are based on the fact that fullerene derivatives possess an extended π-bond system, with high electron and free-radical species
Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells
Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59
- up-regulation of the antioxidant defense system as a possible mechanism for the enhanced cytotoxicity by ZnO:Ag NPs. These findings show that the incorporation of Ag in the nanocomposites substantially enhances the photo-oxidative effect and anticancer activity of the NPs. The presence of Ag
Release behaviour and toxicity evaluation of levodopa from carboxylated single-walled carbon nanotubes
Beilstein J. Nanotechnol. 2015, 6, 243–253, doi:10.3762/bjnano.6.23
- Mytilineou et al. [30], where the LD exposed to mesencephalic cultures at 72 h of treatment was associated with a dose-dependent reduction in cell survival. The authors attributed the potential toxicity of LD to the decreased antioxidant capacity in the limited environment of the cell culture that makes the
Interaction of dermatologically relevant nanoparticles with skin cells and skin
Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245
- antioxidant levels as indicators of oxidative stress [16], it is now increasingly being used to study particle–skin interactions [17][18]. Yet, not all particle types are equally suited for such investigations. In the following, we report our results on confocal Raman microscopy for analyzing the skin
Liquid-phase exfoliated graphene: functionalization, characterization, and applications
Beilstein J. Nanotechnol. 2014, 5, 2328–2338, doi:10.3762/bjnano.5.242
- graphene close to the defects and at the edges. Under prolonged periods of ultrasonication, the oxidation can cut graphene sheets into small pieces. A well-known strategy to mitigate the damage induced by radicals in different biological processes is through the addition of antioxidant. Following this
- approach, the ultrasonication of graphite upon addition of N-(2-mercaptopropionyl)glycine (tiopronin) was reported [9]. Tiopronin is an antioxidant molecule that traps electrons, radicals and peroxides. The ultrasonication of graphite in the presence of tiopronin produced larger graphene layers as compared
- produces dispersions of larger graphene sheets of higher concentration than common ultrasonication in DMF. With this, it was demonstrated that the use of antioxidant molecules during ultrasonication treatments reduces the damage caused by radicals and other oxidizing chemical species, attacking mainly the
Nanobioarchitectures based on chlorophyll photopigment, artificial lipid bilayers and carbon nanotubes
Beilstein J. Nanotechnol. 2014, 5, 2316–2325, doi:10.3762/bjnano.5.240
- stability, good antioxidant and antimicrobial properties, and could be used as biocoating materials. As compared to the cholesterol-free samples, the cholesterol-containing hybrid structures demonstrated better stability (i.e., their zeta potential reached the value of −36.4 mV), more pronounced oxygen
- radical scavenging ability (affording an antioxidant activity of 73.25%) and enhanced biocidal ability, offering inhibition zones of 12.4, 11.3 and 10.2 mm in diameter, against Escherichia coli, Staphylococcus aureus and Enterococcus faecalis, respectively. Keywords: antibacterial activity; antioxidant
- largely used as drug delivery vehicles, showing potential in targeting specific cancer cells [18] with a necessary dosage lower than conventional drugs, without harming healthy cells and significantly reduced side effects. Another interesting property of carbon nanotubes is their antioxidant activity
PVP-coated, negatively charged silver nanoparticles: A multi-center study of their physicochemical characteristics, cell culture and in vivo experiments
Beilstein J. Nanotechnol. 2014, 5, 1944–1965, doi:10.3762/bjnano.5.205
- nanoparticles neither caused toxicity nor oxidative stress, while an incubation for 4 h with 100 µM (10.8 µg mL−1) silver in the form of silver nitrate strongly damaged cultured astrocytes and deprived these cells almost completely of the important antioxidant glutathione [108]. The high resistance of cultured
Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy
Beilstein J. Nanotechnol. 2014, 5, 1616–1624, doi:10.3762/bjnano.5.173
- , several investigations showed that the toxicity increases with decreasing particle sizes, increasing doses and longer exposure times [14][15][16]. In the case of ceria nanoparticles, very contradictory findings have been reported. On the one hand, the anti-inflammatory, antioxidant and radio-protective
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