Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• apolipoprotein A-I and facilitates atherosclerosis [190]. Si nanoparticles were reported for their ability to invade the cytoplasm, modify the intracellular microstructure, and promote inflammatory reactions through activating NLRP3 inflammasomes [191]. Also, in an animal experiment, SiO2 nanoparticles induce

Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer

• Filip Gorachinov,
• Fatima Mraiche,
• Diala Alhaj Moustafa,
• Ola Hishari,
• Yomna Ismail,
• Jensa Joseph,
• Maja Simonoska Crcarevska,
• Marija Glavas Dodov,
• Nikola Geskovski and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2023, 14, 240–261, doi:10.3762/bjnano.14.23

• and exposure of the ionizable lipids at the surface of the LNPs. After dissociation of the PEGylated lipids, the naked surface of the particles containing the ionizable DLin-KC2-DMA, which is neutral in a biological environment, interacts with apolipoprotein E (ApoE), enabling ApoE liver-mediated

Key for crossing the BBB with nanoparticles: the rational design

• Sonia M. Lombardo,
• Marc Schneider,
• Akif E. Türeli and
• Nazende Günday Türeli

Beilstein J. Nanotechnol. 2020, 11, 866–883, doi:10.3762/bjnano.11.72

• toxic effects and did not disrupt the BBB at the dose used [50]. At the same time, Lück published in his thesis that apolipoprotein E (ApoE) was adsorbed on the surface of nanoparticles coated with polysorbate 20, 40, 60 or 80 after their incubation in human plasma [51]. However, ApoE was not adsorbed

• particles as it was shown to be able to increase the apolipoprotein–nanoparticle interaction for a wide range of polymers without any toxicity to the BBB. However, alternatives, such as P188, exist. Furthermore, the efficacy of the coating is also influenced by the composition of the nanoparticle core, i.e

Identification of physicochemical properties that modulate nanoparticle aggregation in blood

• Ludovica Soddu,
• Duong N. Trinh,
• Eimear Dunne,
• Dermot Kenny,
• Giorgia Bernardini,
• Ida Kokalari,
• Arianna Marucco,
• Marco P. Monopoli and
• Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

• , such as histidine-rich glycoprotein, kallikrein B and plasminogen as already shown in the literature [26]. Apolipoprotein A1, a major protein that forms the high-density lipoprotein (HDL), has shown to have a preferential affinity towards silica NPs since it was detected across all conditions. The

• incubation in human plasma. b) Densitometry of the gel bands corresponding to fibrinogen and apolipoprotein A1. Abundance of fibrinogen and apolipoprotein A1 in silica and carbon nanoparticle corona at different plasma concentrations. Venn diagrams showing the number of proteins shared by small silica (black

Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicine

• Valentina Francia,
• Daphne Montizaan and
• Anna Salvati

Beilstein J. Nanotechnol. 2020, 11, 338–353, doi:10.3762/bjnano.11.25

• nanomaterials and can affect the way nanomedicines are recognized and processed by cells [3][7][8][20][21][36][48]. Biomolecules present in the corona can, per se, have targeting capabilities towards particular receptors [17][18][49][50][51][52]. For example, apolipoprotein B and immunoglobulin G in the corona

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• attracted to NPs composed of hydrophobic core materials [30][31] resulting in a prolonged circulation time in blood [18]. Moreover, covalent attachment of apolipoprotein A–I and apolipoprotein E to the NP surface enables drug transport across the blood–brain barrier [32]. Here, both proteins were identified

Optimized design of a nanostructured SPCE-based multipurpose biosensing platform formed by ferrocene-tethered electrochemically-deposited cauliflower-shaped gold nanoparticles

• Wicem Argoubi,
• Maroua Saadaoui,
• Sami Ben Aoun and
• Noureddine Raouafi

Beilstein J. Nanotechnol. 2015, 6, 1840–1852, doi:10.3762/bjnano.6.187

• fractal gold nanostructures for electrodes endowed with very large surface areas useful for the sensitive detection of apolipoprotein E, which is a protein biomarker for Alzheimer’s disease [18]. The preparation of the platforms was achieved in a straightforward manner in few steps. Firstly, home-prepared

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

• Pauline Maffre,
• Stefan Brandholt,
• Karin Nienhaus,
• Li Shang,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2036–2047, doi:10.3762/bjnano.5.212

• formed a monolayer around the NPs. The thickness of the monolayer, ΔRH ≈ 3 nm, was associated with HSA adsorbing in a specific orientation, namely with one of its large triangular faces. In other FCS studies of adsorption of a single type of serum protein onto NPs (apolipoprotein E4, apolipoprotein A1

In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics

• Wolfgang G. Kreyling,
• Stefanie Fertsch-Gapp,
• Martin Schäffler,
• Blair D. Johnston,
• Nadine Haberl,
• Christian Pfeiffer,
• Jörg Diendorf,
• Carsten Schleh,
• Stephanie Hirn,
• Manuela Semmler-Behnke,
• Matthias Epple and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1699–1711, doi:10.3762/bjnano.5.180

• agglomeration behavior [5]. The proteins chosen were albumin, transferrin and apolipoprotein A-1, which exist both in blood serum and in the lung epithelial lining fluid. Protein concentrations before and after NP incubation were determined by a depletion method using the Bio-Rad protein assay. In all cases, a

• protein in the circulation), serum albumin (most abundant blood multi-functional protein), fibrinogen beta (modulation of blood coagulation and opsonisation of foreign bodies [8]), and apolipoprotein E (ApoE) (mediating protein for transcytosis across biological membranes [9][10]). More detected proteins

• groups, but also with polyethylene glycol (PEG) or other polymers or polyelectrolytes and, finally, with tightly grafted plasma proteins (albumin or apolipoprotein E). All AuNP had been radioactively labeled with 198Au by neutron activation in a nuclear research reactor. Most of these studies were

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver

• Markus Heine,
• Alexander Bartelt,
• Oliver T. Bruns,
• Denise Bargheer,
• Artur Giemsa,
• Barbara Freund,
• Ludger Scheja,
• Christian Waurisch,
• Alexander Eychmüller,
• Rudolph Reimer,
• Horst Weller,
• Peter Nielsen and
• Joerg Heeren

Beilstein J. Nanotechnol. 2014, 5, 1432–1440, doi:10.3762/bjnano.5.155

• process that is dependent on the LDL receptor and apolipoprotein E, by hepatocytes. Gene expression analysis of pro-inflammatory markers such as tumor necrosis factor alpha (TNFα) or chemokine (C-X-C motif) ligand 10 (Cxcl10) indicated that 48 h after injection internalized nanocrystals did not provoke

• ]. During peripheral processing within adipose tissues, the remaining lipid micelles become enriched with apolipoprotein E within the vascular system. These particles are then taken up primarily by hepatocytes in a process that is dependent on hepatic lipoprotein receptors such as the LDL receptor and its

• ligand apolipoprotein E, indicating that the nanocrystals did not influence the specificity of the metabolic process [18]. Here we show that substantial amounts of injected QDs–lipid micelles were not only internalized by hepatocytes but also targeted to non-parenchymal hepatic cells, most likely Kupffer

Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy

• Pauline Maffre,
• Karin Nienhaus,
• Faheem Amin,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2011, 2, 374–383, doi:10.3762/bjnano.2.43

• , namely serum albumin, apolipoprotein A-I and apolipoprotein E4, onto polymer-coated, fluorescently labeled FePt nanoparticles (~12 nm diameter) carrying negatively charged carboxyl groups on their surface. For all three proteins, a step-wise increase in hydrodynamic radius with protein concentration was

• properties of the proteins. From structure-based calculations of the surface potentials, positively charged patches of different extents can be revealed, through which the proteins interact electrostatically with the negatively charged nanoparticle surfaces. Keywords: apolipoprotein; dual-focus fluorescence