Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• been applied to treat prostate cancer [56]. This nanoagent shows good drug-loading capacity and photosensitivity and can be applied in NIR photothermal conversion. After the autophagy inhibitor chloroquine (CQ) was loaded onto the nanocarrier, it was coated with prostate cancer cell membrane for tumor

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• antibody (clone 225) functionalization were designed. Their efficacy against human NSCLC cells was evaluated. Increased antitumor efficacy of C225-NPs by inducing apoptosis and autophagy, compared to C225 and the carrier, was reported. The authors mentioned the importance of the three-dimensional

• . Also, in contrast to C225-NPs, free C225 antibody did not induce autophagy in cells [75]. Maya et al. reported the design and evaluation of EGFR-targeted cetuximab–chitosan cross-linked γ-poly(glutamic acid) nanoparticles loaded with docetaxel. The NPs were prepared by cross-linking the NH2 groups of

A review on the biological effects of nanomaterials on silkworm (Bombyx mori)

• Sandra Senyo Fometu,
• Guohua Wu,
• Lin Ma and
• Joan Shine Davids

Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15

• -doped carbon dots (C-NCDs), and to 0.39 µg/µL of Si NPs in order to study the differences in the immune responses and programmed cell death induced in hemocytes [153]. It was shown that autophagy and apoptosis caused by Si NPs were reverted and experimental groups exposed to C-NCDs, CdTe QDs caused

• autophagy, apoptosis, and necrosis in the hemocytes. Xing et al. [154] studied the outcome of introducing Si NPs in the hemolymph of the silkworm. It was reported that 3.9 µg of Si NPs was toxic to the hemocytes when compared to the groups exposed to 0.39 and 0.039 µg of Si NPs. A high dose of Si NPs (3.9

• of nanomaterials, such as Ag NPs, CdTe QDs, and Si NPs have shown to induce an excessive production of ROS, which causes oxidative stress leading to cell apoptosis and autophagy. This review also discussed the effects of nanomaterials on the silk fibers. Reports indicate that the presence of these

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• and lysosomes in microglia [10]. None of the NPs investigated resulted in cytotoxicity, decreased cell viability, apoptosis, autophagy or inflammation. However, exposure to NPs led to oxidative stress via depletion of cellular glutathione and to a downregulation of neuronal differentiation markers in

Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles

• Olga Rotan,
• Katharina N. Severin,
• Simon Pöpsel,
• Alexander Peetsch,
• Melisa Merdanovic,
• Michael Ehrmann and
• Matthias Epple

Beilstein J. Nanotechnol. 2017, 8, 381–393, doi:10.3762/bjnano.8.40

• protein by HTRA2 induces autophagy, resulting in the clearance of damaged mitochondria. Similar as for HTRA1, the functional unit of HTRA2 is a trimer. Each protomer contains a trypsin-like protease domain and one C-terminal PDZ domain. The proteolytic activity can be modulated by binding of the PDZ

Unraveling the neurotoxicity of titanium dioxide nanoparticles: focusing on molecular mechanisms

• Bin Song,
• Yanli Zhang,
• Jia Liu,
• Xiaoli Feng,
• Ting Zhou and
• Longquan Shao

Beilstein J. Nanotechnol. 2016, 7, 645–654, doi:10.3762/bjnano.7.57

• signaling pathways, dysregulated neurotransmitters and synaptic plasticity have also been shown to contribute to neurotoxicity of TiO2 NPs. Recently, studies on autophagy and DNA methylation have shed some light on possible mechanisms of nanotoxicity. Therefore, we offer a new perspective that autophagy and

• investigated comprehensively through studying every possible molecular mechanism. Keywords: autophagy; brain; DNA methylation; neurotoxicity; titanium dioxide nanoparticles; Introduction Titanium dioxide nanoparticles, smaller than 1 μm in at least one dimension, possess specific physico-chemical

• distributions of trace elements, disrupted signaling pathways, dysregulated neurotransmitters and synaptic plasticity (Table 1 and Table 2). Recent studies have reported that autophagy [9] and DNA methylation [10][11] are also involved in nanotoxicity (Table 3). Therefore, we hypothesized that autophagy and DNA