Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene

• Aline Tavares da Silva Barreto,
• Francisco Alexandrino-Júnior,
• Bráulio Soares Arcanjo,
• Paulo Henrique de Souza Picciani and
• Kattya Gyselle de Holanda e Silva

Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139

• innovative strategies to ensure their compatibility and sustained activity. This study addresses this critical challenge through the rational design and fabrication of hybrid core–shell nanofibers manufactured via coaxial electrospinning. Poly(lactic acid) (PLA) was used as an outer shell providing

• -sectional imaging, and attenuated total reflectance with Fourier transform infrared (ATR-FTIR) spectroscopy provided compelling evidence for the successful formation of the intended core–shell structure. The resulting nanofibers exhibited surface hydrophobicity, suggesting potential for anti-adhesive

• properties of nanofibers and create advanced structures with enhanced functionality, coaxial electrospinning can be used to generate nanofibers allowing for the building of a core–shell structure with desirable properties, taking advantage of the positive characteristics of each component (core and shell

Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges

• Natalie Tarasenka

Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137

• experimental parameters: laser pulse duration in the range 4–5 ms was required. The authors also demonstrated the role of Cu comprising the target. Despite the absence in the formed ZnS nanowire structure, the ablation of a single-element Zn target produced only spherical ZnS@Zn core–shell nanostructures

PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation

• Peiyang Gao

Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133

• molar ratio of 50:10:38.5:1.5, SANS analysis revealed a core–shell architecture with an average particle diameter of approximately 75 nm and a LNP shell thickness of 5 to 7 nm. Quantitative modeling of shell composition further demonstrated that the DMPE-PEG2k lipid accounted for 3.0 ± 0.5% of the shell

Prospects of nanotechnology and natural products for cancer and immunotherapy

• Jan Filipe Andrade Santos,
• Marcela Bernardes Brasileiro,
• Pamela Danielle Cavalcante Barreto,
• Ligiane Aranha Rocha and
• José Adão Carvalho Nascimento Júnior

Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116

• ][130][131][132][133]. Polymeric nanoparticles Polymeric nanoparticles are solid colloidal systems of synthetic or natural polymers, which can be organized in hollow, occluded, multilobed, and core–shell structures, depending on their thermodynamic and kinetic characteristics [130]. Polymeric

Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications

• Akshana Parameswaran Sreekala,
• Pooja Raveendran Nair,
• Jithin Kundalam Kadavath,
• Bindu Krishnan,
• David Avellaneda Avellaneda,
• M. R. Anantharaman and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104

• fragmentation. Additionally, the synthesis of heterostructured NPs composed of Au and Co using femtosecond laser techniques demonstrates the creation of metastable structures that can evolve into stable core–shell configurations [38]. These findings emphasize the role of non-equilibrium processes, rapid

• colloidal solutions drop-cast onto Si wafers, indicating the optical quality and defect-related emission of the resulting films. ZnO NPs had irregular shapes in the 10–50 nm range. Also, ZnO and Au NPs with particle sizes of 31 and 20 nm, respectively, and Au:ZnO core–shell nanoparticles (CSNPs) with an

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• new ways in the treatment of incurable diseases by effective gene regulation strategies, such as a three-layer core–shell biomimetic nanostructure fabricated to overcome limitations in siRNA delivery to glioblastoma (Figure 13). The three-layer shell consisted of polyethyleneimine (PEI)-siRNA complex

Time-resolved probing of laser-induced nanostructuring processes in liquids

• Maximilian Spellauge,
• David Redka,
• Mianzhen Mo,
• Changyong Song,
• Heinz Paul Huber and
• Anton Plech

Beilstein J. Nanotechnol. 2025, 16, 968–1002, doi:10.3762/bjnano.16.74

• given by the dielectric functions of metal and medium and are described by Mie theory [113]. Mie theory allows one to derive absolute absorption and scattering cross sections of primarily spherical or core–shell objects, but also different shapes by extensions of the Mie–Gans [114] theory or numerical

Synthesis and magnetic transitions of rare-earth-free Fe–Mn–Ni–Si-based compositionally complex alloys at bulk and nanoscale

• Shabbir Tahir,
• Tatiana Smoliarova,
• Carlos Doñate-Buendía,
• Michael Farle,
• Natalia Shkodich and
• Bilal Gökce

Beilstein J. Nanotechnol. 2025, 16, 823–836, doi:10.3762/bjnano.16.62

• . However, unlike the Ge-based CCA NPs, no visible core–shell structure was detected around the Al-based NPs, and oxygen intensity was significantly lower in line scan analyses (Figure S4, Supporting Information File 1). This suggests that surface oxidation effects were less pronounced, potentially because

Morphology and properties of pyrite nanoparticles obtained by pulsed laser ablation in liquid and thin films for photodetection

• Akshana Parameswaran Sreekala,
• Bindu Krishnan,
• Rene Fabian Cienfuegos Pelaes,
• David Avellaneda Avellaneda,
• Josué Amílcar Aguilar-Martínez and
• Sadasivan Shaji

Beilstein J. Nanotechnol. 2025, 16, 785–805, doi:10.3762/bjnano.16.60

• arises when there is a difference in diffusion rates of the species in the core and shell, leading to the formation of voids within the particle. In our case, there is no presence of core–shell structure but the high viscosity of IPA likely plays a key role in the formation of these hollow structures

• ), and (2018) plane of FeS (d-spacing: 1.61 Å) are identified. For NPs in methanol, (125) plane at 0.97 Å and (211) at 2.2 Å are found. In addition to the planes identified from SAED, (200) plane of pyrite at 2.7 Å is also seen from HRTEM of NPs in acetone. Interestingly, while core–shell NPs with

Changes of structural, magnetic and spectroscopic properties of microencapsulated iron sucrose nanoparticles in saline

• Sabina Lewińska,
• Pavlo Aleshkevych,
• Roman Minikayev,
• Anna Bajorek,
• Mateusz Dulski,
• Krystian Prusik,
• Tomasz Wojciechowski and
• Anna Ślawska-Waniewska

Beilstein J. Nanotechnol. 2025, 16, 762–784, doi:10.3762/bjnano.16.59

• changes upon dissolution in saline were tested. For the undissolved sample, calcium alginate microcapsules with irregular shapes were registered via scanning electron microscopy, inside which core–shell nanoparticles were identified by transmission electron microscopy micrographs. Magnetic studies (DC and

• belong to the hematinic category, are a broad class of medical products in which varied iron agents are used, very often in the form of core–shell nanoparticles, where iron ions (in the structure of iron oxide mineral) are concentrated in the core, and the shell is generally composed of carbohydrates

• core–shell nanoparticle form, where the shell consists of sucrose, while the core is iron(III) oxide mineral. The average diameter of iron sucrose nanoparticles included in Venofer® was estimated as ≈7 nm, whose core diameter is 3 nm [2][7][8][13]. The elemental analysis for a single iron sucrose

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Size control of nanoparticles synthesized by pulsed laser ablation in liquids using donut-shaped beams

• Abdel Rahman Altakroury,
• Oleksandr Gatsa,
• Farbod Riahi,
• Zongwen Fu,
• Miroslava Flimelová,
• Andrei Samokhvalov,
• Stephan Barcikowski,
• Carlos Doñate-Buendía,
• Alexander V. Bulgakov and
• Bilal Gökce

Beilstein J. Nanotechnol. 2025, 16, 407–417, doi:10.3762/bjnano.16.31

• precise compositional control such as metastable binary core–shell NPs [16] and quinary Cantor high-entropy alloy NPs [17][18]. Such high-entropy nanomaterials are recently being discussed as game changers, providing disruptive design opportunities in multifunctional catalysts or magnetic materials [19

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• fabricate multicomponent fibers, where a single nozzle is partitioned into separate chambers, with the most popular technique being the coaxial electrospinning. Coaxial electrospinning involves the use of a compound coannular nozzle to fabricate core–shell fibers [90][91][92]. For a two-solution system, the

• solution with better electrospinning capability, will assist in the entrainment of the core fluid to form core–shell fiber jets. Three-material core–sheath fibers are reported to have been successfully electrospun using triaxial nozzles [94]. Other design variants include having multiple nozzles enclosed

• coaxial electrospinning in which spinneret is conceptualized as two half-cylindrical nozzles joined together. The fibers formed from the process are attached side-by-side instead of a core–shell structure. Figure 8 illustrates the different types of fibers formed using multichamber nozzles. Emulsion

Fabrication of hafnium-based nanoparticles and nanostructures using picosecond laser ablation

• Abhishek Das,
• Mangababu Akkanaboina,
• Jagannath Rathod,
• R. Sai Prasad Goud,
• Kanaka Ravi Kumar,
• Raghu C. Reddy,
• Ratheesh Ravendran,
• Katia Vutova,
• S. V. S. Nageswara Rao and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1639–1653, doi:10.3762/bjnano.15.129

• different liquid media, namely, deionised water (DW), toluene, and anisole, to fabricate HfO2 and HfC NPs along with Hf NSs. Spherical HfO2 NPs and nanofibres were formed when Hf was ablated in DW. Hf ablated in toluene and anisole demonstrated the formation of core–shell NPs of HfC with a graphitic shell

• and HfC in toluene and anisole can be attributed to chemical interactions between the ablated Hf atoms and the liquid medium. Careful observation of high-resolution TEM images revealed the formation of core–shell structures for the particles obtained in anisole and toluene (Figure 4b,c). In contrast

• [11][31] did not discuss the formation of graphite shells around HfC NPs. The formation of polycrystalline HfC core–shell NPs with graphite shells similar to [36] in toluene and anisole can be explained by the possible reaction of carbon from decomposed surrounding liquid with Hf4+ ions in the plasma

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• the nanocarrier and can reduce systemic toxicity [49]. Core–shell type hollow PLHNPs The core–shell type hollow PLHNPs comprise an inner hollow positively charged lipidic core, a polymeric layer in the middle, and an outer PEG lipoidal layer [50]. The inner hollow core of the system is filled with

• circulation and is rapidly eliminated from the body. Therefore, RVT exhibits a very short plasma half-life and very low oral bioavailability These factors significantly reduce its therapeutic efficacy [106][107]. In a study, Kumar et al. fabricated RVT-encapsulated core–shell-type PLHNPs (RVT-PLHNPs) for

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• . Lipid–polymer hybrid NPs are core–shell structures with a polymeric core and lipidic coat [122]. While drug loading and permeability are regulated by the lipidic coat, the polymeric core determines the release properties of the NPs [123]. Lecithin (lipid)–chitosan (polymer) NPs have been studied for N2B

• irradiation increased the mRNA expression in the cytoplasm [160]. In addition to polyplexes, lipoplexes, another widely used vector, have also been studied for siRNA delivery. For instance, Hu et al. described the encapsulation of siRNA (specifically of c-Myc-targeting siRNA) in a core–shell lipoplex for

• modification with PEG and RVG29 improved the intranasal delivery of the NPs [163]. Li et al. also worked on RVG29 and developed core–shell lesion-recognizing NPs consisting of RVG29 peptide-modified mesenchymal stem cell-derived exosomes as the shell and a reactive oxygen species-responsive polymer loaded with

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• ][156][157][158][159]; and Table 2 provides a quantitative assessment of tumor uptake for actively targeted usNPs compared to control groups, limited to studies including quantitative values of % ID/g. 5.1 Folic acid ligand/folate receptor Wu et al. developed core–shell silica NPs (Cornell dots, or C

Recent progress on field-effect transistor-based biosensors: device perspective

• Billel Smaani,
• Fares Nafa,
• Mohamed Salah Benlatrech,
• Ismahan Mahdi,
• Hamza Akroum,
• Mohamed walid Azizi,
• Khaled Harrar and
• Sayan Kanungo

Beilstein J. Nanotechnol. 2024, 15, 977–994, doi:10.3762/bjnano.15.80

• nanotube junctionless surrounding heterogate structure combined with junctionless concept, and tunnel mechanism of carrier transport [60] in comparison with other conventional metal gate TFET-biosensors, such as core–shell junctionless TFET (CS NT JL TFET)-based biosensors [62] and PKD TFET-based

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• ]. It has been found that PLGA may co-encapsulate a range of hydrophobic and hydrophilic compounds, which, because of the core–shell structures, boosts their therapeutic anti-tumor activity [1][2][3][11][26][27][28][29][30][31][32][33]. In this study, we would want to combine all of the advantages of

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• production. With a coaxial needle design, two different solutions can be electrospun simultaneously, and core–shell or hollow fibers can be formed [47]. The main parameters affecting fiber morphology are described in the following. Process parameters Flow rate, voltage, distance, collector type

• ][90]. In cases where the burst effect is not desired, hydrophobic polymer blends need to be used. Furthermore, either core–shell or laminated nanofibers can be produced [32][91]. The degradation of polymers, the diffusion of the active material, or both of them may affect the extended release phase

A review on the structural characterization of nanomaterials for nano-QSAR models

• Salvador Moncho,
• Eva Serrano-Candelas,
• Jesús Vicente de Julián-Ortiz and
• Rafael Gozalbes

Beilstein J. Nanotechnol. 2024, 15, 854–866, doi:10.3762/bjnano.15.71

• [41]. Similarly, categories for the ligands are used in a quasi-SMILES-related model for single core–shell quantum dots [55]. Alternatively, other authors combined all components in a single fingerprint without differentiating the composition of core and coating [32]. Size and nanoshape (c): The most

Synthesis of silver–palladium Janus nanoparticles using co-sputtering of independent sources: experimental and theorical study

• Maria J. Martínez-Carreón,
• Francisco Solís-Pomar,
• Abel Fundora,
• Claudio D. Gutiérrez-Lazos,
• Sergio Mejía-Rosales,
• Hector N. Fernández-Escamilla,
• Jonathan Guerrero-Sánchez,
• Manuel F. Meléndrez and
• Eduardo Pérez-Tijerina

Beilstein J. Nanotechnol. 2024, 15, 808–816, doi:10.3762/bjnano.15.67

• evaporated concurrently in the aggregation region, which results in the formation of nanoparticles with a variety of structural motifs, such as randomly alloyed, core–shell, and Janus nanoparticles [2]. The study of bimetallic nanoparticles (BNPs) is highly interesting for the scientific community because of

• promote twin proliferation, which favored the production of Pd−Au Janus icosahedra. In the same experimental setup, they also promoted twin elongation, which aided the production anisotropic Pd@Au core–shell starfish-like structures. As it is known, icosahedral nanoparticles are formed by 20 tetrahedral

Laser synthesis of nanoparticles in organic solvents – products, reactions, and perspectives

• Theo Fromme,
• Sven Reichenberger,
• Katharine M. Tibbetts and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2024, 15, 638–663, doi:10.3762/bjnano.15.54

• ][101][153][154], depending on the metal’s properties (i.e., carbon affinity). Zhang et al. researched the metal’s influence on the formed carbon species by ablation of 16 different transition metals in acetone and categorized the obtained core–shell structures into three classes depending on the

Aero-ZnS prepared by physical vapor transport on three-dimensional networks of sacrificial ZnO microtetrapods

• Veaceslav Ursaki,
• Tudor Braniste,
• Victor Zalamai,
• Emil Rusu,
• Vladimir Ciobanu,
• Vadim Morari,
• Daniel Podgornii,
• Pier Carlo Ricci,
• Rainer Adelung and
• Ion Tiginyanu

Beilstein J. Nanotechnol. 2024, 15, 490–499, doi:10.3762/bjnano.15.44

• aero-semiconductor materials [11][12][13][14][15][16][17][18], including aero-ZnS materials [16]. The HVPE installation consists of two chambers. In the first chamber, ZnS/ZnO core–shell structures are grown through transporting vapors from the CdS powder source to the ZnO substrate by a H2 flow. The

• final ZnS aero-semiconductor material is produced in the second chamber by heating the ZnS/ZnO core–shell structures in a H2 atmosphere. Thus, the sacrificial ZnO template is dissolved from the ZnS/ZnO core–shell structures. In contrast, in this paper, all technological procedures occur in a single

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• personalized and targeted treatments for sclerosis. Recently developed Fe3O4–CeO2 core–shell NPs have shown great potential as platforms for both the diagnosis and treatment of vascular disorders associated with ROS. This is attributed to their impressive magnetic resonance imaging (MRI) capabilities and