Inorganic Janus particles for biomedical applications

• Isabel Schick,
• Steffen Lorenz,
• Dominik Gehrig,
• Stefan Tenzer,
• Wiebke Storck,
• Karl Fischer,
• Dennis Strand,
• Frédéric Laquai and
• Wolfgang Tremel

Beilstein J. Nanotechnol. 2014, 5, 2346–2362, doi:10.3762/bjnano.5.244

• precursors were mixed simultaneously. Janus particles as multimodal contrast agents Recent developments in the field of nanoparticles for biomedical applications have increased the interest in multifunctional nanoparticles for theranostics, a combination of therapy and diagnostics, which was realized with

• resonance. Additionally, the gold nanoparticles exhibit a strong X-ray absorption, which can be used to increase the contrast in CT diagnostics [90], as shown by the combination of gold nanoparticles with iron oxide to create multifunctional hetero-nanoparticles for simultaneous MRI and CT imaging [66][91

Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells

• Heike Sinnecker,
• Katrin Ramaker and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2308–2315, doi:10.3762/bjnano.5.239

• Heike Sinnecker Katrin Ramaker Andreas Frey Division of Mucosal Immunology & Diagnostics, Priority Program Asthma & Allergy, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 22, 23845 Borstel, Germany, Member of the German Center for Lung Research 10.3762/bjnano

Nanoencapsulation of ultra-small superparamagnetic particles of iron oxide into human serum albumin nanoparticles

• Matthias G. Wacker,
• Mahmut Altinok,
• Stephan Urfels and
• Johann Bauer

Beilstein J. Nanotechnol. 2014, 5, 2259–2266, doi:10.3762/bjnano.5.235

• with the surface modification and nanoencapsulation of USPIO into an albumin matrix by using ethanolic desolvation. Particles of narrow size distribution and with a defined particle structure have been achieved. Keywords: diagnostics; HSA; nanoencapsulation; nanoparticles; USPIO; Introduction Over

The gut wall provides an effective barrier against nanoparticle uptake

• Heike Sinnecker,
• Thorsten Krause,
• Sabine Koelling,
• Ingmar Lautenschläger and
• Andreas Frey

Beilstein J. Nanotechnol. 2014, 5, 2092–2101, doi:10.3762/bjnano.5.218

• Heike Sinnecker Thorsten Krause Sabine Koelling Ingmar Lautenschlager Andreas Frey Division of Mucosal Immunology & Diagnostics, Priority Program Asthma & Allergy, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 22, Borstel, 23845, Germany, Airway Research Center

Influence of surface-modified maghemite nanoparticles on in vitro survival of human stem cells

• Michal Babič,
• Daniel Horák,
• Lyubov L. Lukash,
• Tetiana A. Ruban,
• Yurii N. Kolomiets,
• Svitlana P. Shpylova and
• Oksana A. Grypych

Beilstein J. Nanotechnol. 2014, 5, 1732–1737, doi:10.3762/bjnano.5.183

• labeling of cells in order to track them both in diagnostics and therapeutics [1][2]. For example, mesenchymal [3], neural [4], and bone marrow [5] stem cells, as well as other cells are widely labeled by surface-coated iron oxide nanoparticles. Other applications of nanoparticles involve the delivery of

• cells. Surface modifications are already well described as the particles are used in many applications, such as magnetic contrast agents, separations, diagnostics, drug delivery, and hyperthermia [13][14][15][16][17]. In terms of coating, many low- and high-molecular-weight compounds were proposed, e.g

Donor–acceptor graphene-based hybrid materials facilitating photo-induced electron-transfer reactions

• Anastasios Stergiou,
• Georgia Pagona and
• Nikos Tagmatarchis

Beilstein J. Nanotechnol. 2014, 5, 1580–1589, doi:10.3762/bjnano.5.170

• , although graphene-based biomaterials are out of the scope of this mini-review, GO has been covalently functionalized with peptides, antibodies and other biomolecules for applications in diagnostics, novel therapeutic approaches and near infrared (NIR) photo-thermal therapies [53]. A representative work

Protein-coated pH-responsive gold nanoparticles: Microwave-assisted synthesis and surface charge-dependent anticancer activity

• Dickson Joseph,
• Nisha Tyagi,
• Christian Geckeler and
• Kurt E.Geckeler

Beilstein J. Nanotechnol. 2014, 5, 1452–1462, doi:10.3762/bjnano.5.158

• cell viability for cancerous cells in comparison to fibroblasts. Hence, increasing evidence from these studies is pointing that by controlling the concentrations of the AuNPs, anticancer agents can be formulated. These synthesized AuNPs show promise for use in biomedical applications for diagnostics

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats

• Nadine Haberl,
• Stephanie Hirn,
• Alexander Wenk,
• Jörg Diendorf,
• Matthias Epple,
• Blair D. Johnston,
• Fritz Krombach,
• Wolfgang G. Kreyling and
• Carsten Schleh

Beilstein J. Nanotechnol. 2013, 4, 933–940, doi:10.3762/bjnano.4.105

• nm with the Cytotoxicity Detection KitPLUS (LDH; Roche Diagnostics, Mannheim, Germany). Both assays were performed according to the manufacturers’ instructions. Quantification of TNF-α and CINC-1 levels in BALF by ELISA TNF-α and cytokine-induced neutrophil chemoattractant-1 (CINC-1) were measured in

Porous polymer coatings as substrates for the formation of high-fidelity micropatterns by quill-like pens

• Michael Hirtz,
• Marcus Lyon,
• Wenqian Feng,
• Andrea E. Holmes,
• Harald Fuchs and
• Pavel A. Levkin

Beilstein J. Nanotechnol. 2013, 4, 377–384, doi:10.3762/bjnano.4.44

• cell analysis) and medical applications in diagnostics such as the detection of pathogens or antibodies. Nitrocellulose films and nylon membranes are widely used as carriers for microarrays, usually with spot sizes in the range of 100 to 500 µm, easily accessible for current inkjet and spotting

Effect of large mechanical stress on the magnetic properties of embedded Fe nanoparticles

• Srinivasa Saranu,
• Sören Selve,
• Ute Kaiser,
• Luyang Han,
• Ulf Wiedwald,
• Paul Ziemann and
• Ulrich Herr

Beilstein J. Nanotechnol. 2011, 2, 268–275, doi:10.3762/bjnano.2.31

• sensors. In this context, it should be noted that magnetic nanoparticles also have applications in other fields, such as medical treatment, diagnostics and imaging [9]. A precise control of the magnetic anisotropy energy is most important for the design of future magnetic data storage media. The total

Structural and magnetic properties of ternary Fe_1–xMn_xPt nanoalloys from first principles

• Markus E. Gruner and
• Peter Entel

Beilstein J. Nanotechnol. 2011, 2, 162–172, doi:10.3762/bjnano.2.20

• technological fields, such as biomedical diagnostics or therapy, catalysis or even mechanical actuation [1][2][3][4][5][6][7][8][9] and have become the focus of much research. Another application, widely discussed in recent years, is in the field of ultra-high density magnetic recording. Here, an exponential

Magnetic nanoparticles for biomedical NMR-based diagnostics

• Huilin Shao,
• Tae-Jong Yoon,
• Monty Liong,
• Ralph Weissleder and
• Hakho Lee

Beilstein J. Nanotechnol. 2010, 1, 142–154, doi:10.3762/bjnano.1.17

• enabled parallel and sensitive measurements to be made from small volume samples. Thus, the DMR technology is a highly attractive platform for portable, low-cost, and efficient biomolecular detection within a biomedical setting. Keywords: biosensor; diagnostics; magnetic nanoparticle; microfluidics

• removed excess unbound MNPs but also retained the BCG bacteria; thus was effective for both concentrating scant bacteria and removing background signal. In comparison to standard TB diagnostics, which involve time-consuming culture and acid-fast bacilli (AFB) smear microscopy, the DMR diagnostic

• ensure detection sensitivity of this assay mode. (Reproduced with permission from [13][14]. Copyright 2002, 2008 Nature Publishing Group.) Higher r2-relaxivity MNPs developed to improve detection sensitivity of in vitro diagnostics. (a) Transmission electron micrograph (TEM) images of manganese-doped

Preparation, properties and applications of magnetic nanoparticles

• Ulf Wiedwald and
• Paul Ziemann

Beilstein J. Nanotechnol. 2010, 1, 21–23, doi:10.3762/bjnano.1.4

• magnetic data storage, the use of such particles in the much broader field of sensor technology is described including especially medical diagnostics. We hope that the selection of review articles as well as full research papers we have chosen is found consistent and useful by the readers interested in