Beilstein J. Nanotechnol.2019,10, 2192–2206, doi:10.3762/bjnano.10.212
: atom transfer radical polymerization (ATRP); glycopolymer; lectin; poly(ethylene glycol); poly(ε-caprolactone); ring-opening polymerization (ROP); Introduction
Carbohydrate–protein interactions are involved in many biological processes, including cell recognition and cell–cell adhesion. These
] (Figure 6A). Glycopolymers were tested in the presence of Con A in HBS buffer at pH 7.4. A fixed mannose concentration 2.5 times higher than the Con A binding site concentration was used, and turbidity was measured using an UV–vis spectrometer (Figure 7). The kinetics of glycopolymer-induced clustering
. In the case of the divalent compound PEG8-PCL2-Man2, the absorbance quickly reached a plateau and then remained almost constant, although a stepwise variation of the OD indicated a partial precipitation of the aggregates, as shown in Figure 6B. The same happened for the octavalent glycopolymer A4
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Figure 1:
Synthetic approach (upper panel), final structure and nomenclature (lower panels) of the mannose-fu...