Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• BBB permeability, which restricts the treatment of brain-related diseases [49]. Aggressive metastases to brain tumors are common in various types of tumors, such as melanoma, lung cancer, and breast cancer [27]. These tumor cells are able to cross the BBB and adhere to brain tissue. This process is

• closely associated with membrane-associated components such as syndecan-1 [50], vascular cell adhesion molecule-1 (VCAM-1), and activated leukocyte cellular adhesion molecule (ALCAM) [51]. In a study on the ability of cancer cell membranes to penetrate the BBB, NPs coated with cell membranes from melanoma

• porphyrin-based nanozymes were designed and successfully delivered to the TME with encapsulation by the melanoma B16F10M cell membrane [82]. They can generate •OH by catalyzing excess H2O2 to exert a toxic effect on tumor cells [82]. This precise delivery of anticancer modalities shows great significance

Single-step extraction of small-diameter single-walled carbon nanotubes in the presence of riboflavin

• Polina M. Kalachikova,
• Anastasia E. Goldt,
• Eldar M. Khabushev,
• Timofei V. Eremin,
• Timofei S. Zatsepin,
• Elena D. Obraztsova,
• Konstantin V. Larionov,
• Liubov Yu. Antipina,
• Pavel B. Sorokin and
• Albert G. Nasibulin

Beilstein J. Nanotechnol. 2022, 13, 1564–1571, doi:10.3762/bjnano.13.130

• such as melanoma, luminal 45 A breast cancer, and squamous cell carcinoma. Riboflavin-covered SWCNTs have immense potential in detecting tumors since riboflavin is selectively attached to the riboflavin carrier protein in the tumor cells while the photoluminescence increased by SWCNTs allows for high

Frequency-dependent nanomechanical profiling for medical diagnosis

• Santiago D. Solares and
• Alexander X. Cartagena-Rivera

Beilstein J. Nanotechnol. 2022, 13, 1483–1489, doi:10.3762/bjnano.13.122

• than a single scalar quantity such as a modulus of elasticity, and from which traditional viscoelastic quantities can be obtained, such as the storage and loss modulus (which are also frequency dependent). Figure 3 provides an example of storage and loss modulus estimates for cancerous human melanoma

Photothermal ablation of murine melanomas by Fe₃O₄ nanoparticle clusters

• Xue Wang,
• Lili Xuan and
• Ying Pan

Beilstein J. Nanotechnol. 2022, 13, 255–264, doi:10.3762/bjnano.13.20

• Xue Wang Lili Xuan Ying Pan Department of Obstetrics & Gynecology, China–Japan Union Hospital of Jilin University, Changchun, People’s Republic of China 10.3762/bjnano.13.20 Abstract Melanoma is one of the deadliest forms of cancer, for which therapeutic regimens are usually limited by the

• development of resistance. Here, we fabricated Fe3O4 nanoparticle clusters (NPCs), which have drawn widespread attention, and investigated their role in the treatment of melanoma by photothermal therapy (PTT). Scanning electron microscopy imaging shows that our synthesized NPCs are spherical with an average

• ablated A375 melanoma cells by inducing overt apoptosis. Consistently, in vivo studies using BALB/c mice found that intratumoral administration of Fe3O4 NPCs and concomitant in situ exposure to near-infrared light significantly inhibited the growth of implanted tumor xenografts. Finally, we revealed, by

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• calculated by the formula given in Equation 4: Cell culture The cell lines human malignant melanoma (HT144, ATCC® HTB-63™) and human hepatocellular carcinoma (HepG2, ATCC®HB-8065™) were used in this study. The cells were grown in DMEM supplemented with 10% FCS and 1% GPPS in a humidified incubator (37 °C

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• melanoma cells, respectively) was observed when using doses up to 100 μM. In vivo (C57BL/6 mice) data showed that a topical application prevented regrowth and metastasis of excised tumors (melanoma), in contrast to a significant recurrence (70%) in untreated animals. Based on their data, the authors

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• [30]. Phytosomes have been used as drug delivery systems of several insoluble natural drugs in recent years. Sinigrin [31] and epigallocatechin-3-O-gallate [32] loaded in phytosomes showed stronger antiproliferative activity than free drugs against melanoma cells and breast cancer cells. In this work

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• nanoparticles (without Dox). We have chosen the HeLa immortal cell line derived from cervical cancer, human T-leukemia cells Jurkat, K562, HL-60/wt and its drug-resistant HL-60/vinc subline, the highly metastatic murine B16F10/wt melanoma cell line, and the human osteosarcoma MG63 cell line. As a model of human

• Mouse melanoma cells of B16F10/wt line, human T-leukemia cells of Jurkat, K562, HL-60 lines and its drug-resistant HL-60/vinc sub-line (overexpression of P-glycoprotein) were a kind gift of Prof. Walter Berger, Institute of Cancer Research, Vienna Medical University (Austria). Human mesenchymal stem

• fluorescence (617 nm) after excitation by green light (528 nm). All experiments were carried out in triplicate. Finally, DAPI staining was used for determination of chromatin hypercondensation in the B16 melanoma cells treated with the Dox and its complexes for 24 h. After the treatment with γ-Fe2O3@PHPMA

Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

• Liga Saulite,
• Karlis Pleiko,
• Ineta Popena,
• Dominyka Dapkute,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

• to U251 glioma cells and induce cancer cell apoptosis [9]. Moreover, MSCs carrying poly(lactic-co-glycolic acid) (PLGA) NPs linked with paclitaxel selectively accumulate in an orthotopic A549 lung tumour model [2]. It has been reported that IFN-beta secreting MSCs could integrate into A375SM melanoma

Nano-engineered skin mesenchymal stem cells: potential vehicles for tumour-targeted quantum-dot delivery

• Liga Saulite,
• Dominyka Dapkute,
• Karlis Pleiko,
• Ineta Popena,
• Simona Steponkiene,
• Ricardas Rotomskis and
• Una Riekstina

Beilstein J. Nanotechnol. 2017, 8, 1218–1230, doi:10.3762/bjnano.8.123

• ]. MSCs loaded with anti-cancer drugs can reduce melanoma tumour growth in vivo, suggesting that these molecules are suitable vectors for therapeutic applications [22]. The aim of the present study was to analyse the accumulation, release, toxicity and functional effects of carboxyl QD655 on skin-derived

• therapeutic nano-agents [24]. Studies on melanoma [25], prostate cancer [26], breast cancer [6] and lung cancer [27] have shown the ability of MSCs to home to cancer sites in vivo. In the tumour microenvironment, MSCs play a role in the formation of the tumour stroma and support cancer metastasis [28

• ]. Lourenco et al. showed that MSC migration towards cancer cells is induced by MIF–CXCR4 chemotaxis [29]. Moreover, in close proximity of the tumour, cancer-associated fibroblast formation is induced by the release of vesicles containing miRNA from cancer cells. This leads to melanoma growth and invasion [30

Influence of hydrothermal synthesis parameters on the properties of hydroxyapatite nanoparticles

• Sylwia Kuśnieruk,
• Jacek Wojnarowicz,
• Agnieszka Chodara,
• Tadeusz Chudoba,
• Stanislaw Gierlotka and
• Witold Lojkowski

Beilstein J. Nanotechnol. 2016, 7, 1586–1601, doi:10.3762/bjnano.7.153

• nanoparticles (nano-HAp) are better positioned to serve as an apatite substitute of bone in biomedical applications than micrometer-sized hydroxyapatite (micro-HAp) [8]. The impact of nano-HAp particles with different morphology on highly malignant melanoma cells was analyzed. The obtained results showed that

On the pathway of cellular uptake: new insight into the interaction between the cell membrane and very small nanoparticles

• Claudia Messerschmidt,
• Daniel Hofmann,
• Anja Kroeger,
• Katharina Landfester,
• Volker Mailänder and
• Ingo Lieberwirth

Beilstein J. Nanotechnol. 2016, 7, 1296–1311, doi:10.3762/bjnano.7.121

• ), human epithelial colorectal adenocarcinoma cells (Caco-2) and mouse melanoma (B16-F10) cells. Caco-2 cells are very often used as model of the human intestinal barrier. Furthermore we investigated HeLa and U2OS cells. These cell lines were not derived from directly relevant tissues but can serve as

Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells

• Syeda Arooj,
• Samina Nazir,
• Akhtar Nadhman,
• Nafees Ahmad,
• Bakhtiar Muhammad,
• Ishaq Ahmad,
• Kehkashan Mazhar and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2015, 6, 570–582, doi:10.3762/bjnano.6.59

• . The NPs were investigated with regard to their different photocatalytic cytotoxic effects in human malignant melanoma (HT144) and normal (HCEC) cells. The ZnO:Ag nanocomposites killed cancer cells more efficiently than normal cells under daylight exposure. Nanocomposites having higher Ag content (10

• of the particles but might also improve their anticancer effects. In this study, we investigated ZnO and different ZnO:Ag (1–30%) nanocomposites with regard to their cytotoxic effect in human malignant melanoma cells (HT144) and normal cells (HCEC). Combined with the MTT and sulforhodamine B (SRB

• , 10, 20, and 30% Ag). Silver resulted in a band structure in visible region in all the ZnO:Ag nanocomposites (Figure 3c). Screening of NPs for cytotoxicity The ZnO:Ag nanocomposites were screened for cytotoxicity against two cell lines, HT144 (human malignant melanoma) and HCEC (normal cell line). The

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

• Yasuhiko Onishi,
• Yuki Eshita,
• Rui-Cheng Ji,
• Masayasu Onishi,
• Takashi Kobayashi,
• Masaaki Mizuno,
• Jun Yoshida and
• Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

• complex is considered to be useful as a drug delivery system (DDS) for anticancer compounds since it formed a stable polymeric micelle in water. The resistance of B16F10 melanoma cells to PTX was shown clearly through a maximum survival curve. Conversely, the DDMC/PTX complex showed a superior anticancer

• -resistant melanoma cell line, even at low concentrations [24]. It is thought that the supramolecular DDMC/PTX complex produced conformational flexibility on its structure, which did not generate MDR, but promoted allosteric modulation. The supramolecular DDMC/PTX complex also demonstrated substrate

• high ζ-potential of the particles, it seems that the DDMC/PTX complex may have a stable hole (cave) of a hydrophobic pocket, which is required for the clathration of a substrate. Anticancer activity Anticancer activity of the DDMC/PTX complex on melanoma B16F10 cells in vitro In 1920, the German

Magnetic-Fe/Fe₃O₄-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages

• Hongwang Wang,
• Tej B. Shrestha,
• Matthew T. Basel,
• Raj K. Dani,
• Gwi-Moon Seo,
• Sivasai Balivada,
• Marla M. Pyle,
• Heidy Prock,
• Olga B. Koper,
• Prem S. Thapa,
• David Moore,
• Ping Li,
• Viktor Chikan,
• Deryl L. Troyer and
• Stefan H. Bossmann

Beilstein J. Nanotechnol. 2012, 3, 444–455, doi:10.3762/bjnano.3.51

• reported. Recently, we described a self-contained enzyme-activating prodrug cytotherapy for preclinical melanoma [27]. CPT-11 was loaded into double-stable RAW264.7 monocyte/macrophage-like cells (Mo/Ma) containing a Tet-On Advanced system for intracellular carboxylesterase (InCE) expression. The double

• -stable Mo/Ma homed to the lung melanoma within one day and successfully delivered the prodrug-activating enzyme/prodrug package to the tumors. Significantly reduced tumor weights and numbers were observed after activation of InCE. We also showed that these cells can carry the SN38–dextran irinotecan-like