Beilstein J. Nanotechnol.2012,3, 556–563, doi:10.3762/bjnano.3.64
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Keywords: DNA repair; heavy ions; microdosimetry; Monte Carlo simulations; nanolesions; radiation-induced nanostructures; Introduction
In a low-dose field of γ-rays, such as that normally experienced on Earth due to background radiation, each human cell is traversed by very few electrons, which hence
less compact state (high GC content) could be a more favorable environment for γH2AX spreading than highly compact heterochromatin [14].
MCHIT simulations of microdosimetry distributions
The Monte Carlo method is a convenient technique to account for the interactions of beam nuclei and all secondary
. The energy ε delivered to the small sensitive volume in a single event fluctuates due to the stochastic nature of particle propagation in media. Microdosimetry measurements provide the probability distributions for lineal energy defined as y = ε/, where is the mean chord length of the sensitive
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Figure 1:
Bending of linear ion-induced γH2AX streaks indicates chromatin density-dependent damage relocation...