Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• exhibited excellent performance in repairing bone defects [3][26], healing diabetic foot ulcers [27], promoting hemostasis [28], acting as anti-leishmanial drugs [29], and inhibiting microbial agents [27][30]. Zhou et al. [31] developed hybrids of nanofibers and microparticles for dual-step controlled

• release of BBR, combining a fast-release step of BBR from hydrophilic polypyrrolidone nanofibers (47.9 wt % in the first hour) and a sustained-release step of BBR from the insoluble cellulose acetate microparticles (98.6 wt % for 60 h). In comparison with the aforementioned hybrid nanofibers, the release

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• promising biological properties, particularly antioxidant activity. However, its medical applications are limited due to its low water solubility, bioavailability, and pH-instability. CUR-loaded albumin microparticles (CUR-HSA-MPs) of submicron size in the range of 800 to 900 nm and a zeta potential of −15

• recently developed method of encapsulation to produce high-quality submicron albumin particles loaded with riboflavin [28] or doxorubicin [29]. In this work, our aim was to determine the ability of albumin microparticles to load CUR by adsorption and to investigate binding with and release from the

• microparticles. The incorporation of CUR within the versatile biomolecular platform MnCO3-HSA-MPs has not been previously reported. The obtained albumin microparticles are expected to enhance the water solubility of CUR, provide controlled release, and improve its biological activity. These peanut-shaped

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• in the uptake of HbMPs. Further research on this topic will be conducted in the future. To be considered as well is a possible mechanism leading to particle uptake by phagocytes based on the particle size. Our own results regarding PMMA-FluoroGreen-COOH particles (microparticles GmbH, Berlin, Germany

Polymer nanoparticles from low-energy nanoemulsions for biomedical applications

• Santiago Grijalvo and
• Carlos Rodriguez-Abreu

Beilstein J. Nanotechnol. 2023, 14, 339–350, doi:10.3762/bjnano.14.29

• . Conventional emulsification methods generally yield nanoparticles with sizes larger than those described above. For example, emulsions prepared with poly(vinylalcohol) (PVA) as stabilizer produce PLGA polymer microparticles with a size of several tens of micrometers after extraction or evaporation of the

A novel approach to pulsed laser deposition of platinum catalyst on carbon particles for use in polymer electrolyte membrane fuel cells

• Bogusław Budner,
• Wojciech Tokarz,
• Sławomir Dyjak,
• Andrzej Czerwiński,
• Bartosz Bartosewicz and
• Bartłomiej Jankiewicz

Beilstein J. Nanotechnol. 2023, 14, 190–204, doi:10.3762/bjnano.14.19

• supports in the form of nano- and microparticles. Herein, we report on the deposition of platinum on carbon particles using PLD to fabricate cost-efficient catalysts for PEMFCs with good performance. The research aimed to develop an effective physical method of PtNP deposition on carbon supports directly

Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• introduced into systems whose purpose is to provide the expected concentration in the treated tissue for the desired time period. The most frequently studied and described are liposomes [60][61], micelles [60][62], microparticles [63][64][65], nanoparticles [66][67], micro- [68][69], and nanoemulsions [70

• ], calcium sulfate and gelatin [135], gelatin and hydroxyapatite [136], and PLGA microparticles combined with PLA [137] are available in the scientific literature. Taking into consideration the shape and geometry of microneedles, they can be categorized as pyramids, cones, arrowheads, cylinders, bullets

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• compounds with diameters from 1 to 1000 μm prepared by physicochemical methods [20]. A microsphere-based controlled release strategy is extensively used in scaffold fabrication because of the remarkable ability of microparticles to serve as carriers for delivery of drugs, bioactive molecules, and growth

Systematic studies into uniform synthetic protein nanoparticles

• Nahal Habibi,
• Ava Mauser,
• Jeffery E. Raymond and
• Joerg Lahann

Beilstein J. Nanotechnol. 2022, 13, 274–283, doi:10.3762/bjnano.13.22

• ]. Electrohydrodynamic (EHD) co-jetting is a versatile technology that has been utilized to fabricate compartmentalized microparticles and nanoparticles [20][21][22]. Key properties of these drug delivery carriers include tunable payload delivery kinetics, the presence of multiple drug-loaded compartments, and

Bacterial safety study of the production process of hemoglobin-based oxygen carriers

• Axel Steffen,
• Yu Xiong,
• Radostina Georgieva,
• Ulrich Kalus and
• Hans Bäumler

Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8

• /bjnano.13.8 Abstract Hemoglobin microparticles (HbMP) produced with a three-step procedure, including coprecipitation of hemoglobin with manganese carbonate, protein cross-linking, and dissolution of the carbonate template were shown to be suitable for application as artificial oxygen carriers. First

• final particle suspensions. Therefore, we conclude that the HbMP fabrication procedure is safe in respect of bacterial contamination. Keywords: bacterial safety; EDTA; glutaraldehyde; hemoglobin; microparticles; Introduction Artificial oxygen carriers used as red blood cell (RBC) substitutes have

• chemically modified, cross-linked, polymerized, or encapsulated by various methods [1][2][3]. We produce biopolymer microparticles as HBOC with the simple coprecipitation–cross-linking–dissolution (CCD) technique while utilizing hemoglobin. Depending on the biopolymer used, there are also various other

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

Recent progress in magnetic applications for micro- and nanorobots

• Ke Xu,
• Shuang Xu and
• Fanan Wei

Beilstein J. Nanotechnol. 2021, 12, 744–755, doi:10.3762/bjnano.12.58

• microparticles to more complex structures, deeper exploration and research on MNRs are gradually realized. In 2012, Falcaro et al. [54] proposed the use of external magnetic fields to locate single metal-organic framework nanoparticles, leading to the potential application of magnetic nanoparticles as active

Stability and activity of platinum nanoparticles in the oxygen electroreduction reaction: is size or uniformity of primary importance?

• Kirill O. Paperzh,
• Anastasia A. Alekseenko,
• Vadim A. Volochaev,
• Ilya V. Pankov,
• Olga A. Safronenko and
• Vladimir E. Guterman

Beilstein J. Nanotechnol. 2021, 12, 593–606, doi:10.3762/bjnano.12.49

• hydrogen oxidation or an organic reducing agent oxidation (e.g. methanol) occur [4][5]. The need to carry out high-rate electrode reactions requires electrocatalysts (i.e., platinum nanoparticles – NPs – or its alloys), deposited mainly onto nano/microparticles of carbon supports, which are currently the

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

• developed E-selectin-targeted porous silicon particles with capabilities for selective uptake to the BM [35]. The authors formulated a multistage carrier composed of porous silica microparticles that encapsulate nanoscale paclitaxel-loaded liposomes. The porous silica particles were decorated with E

Thermophoretic tweezers for single nanoparticle manipulation

• Jošt Stergar and
• Natan Osterman

Beilstein J. Nanotechnol. 2020, 11, 1126–1133, doi:10.3762/bjnano.11.97

• tweezers can be used to individually trap nano- and microparticles or molecules in a liquid environment as long as their thermodiffusion coefficient is non-zero and their spatial position can be detected. The stiffness of the trap depends on the Soret coefficient of the trapped particle, thermal gradient

Integrated photonics multi-waveguide devices for optical trapping and Raman spectroscopy: design, fabrication and performance demonstration

• Gyllion B. Loozen,
• Arnica Karuna,
• Mohammad M. R. Fanood,
• Erik Schreuder and
• Jacob Caro

Beilstein J. Nanotechnol. 2020, 11, 829–842, doi:10.3762/bjnano.11.68

• trapping of biological microparticles. The experimental values of the normalized stiffness of the 16-waveguide trap are clearly higher than for the 2-waveguide trap. Raman spectra of the trapped beads, induced by the multiple beams also used for trapping, show clear Raman peaks of polystyrene in spite of a

• background results from the interplay of the particle size and the degree of confocal filtering. The successful optical trapping of polystyrene microparticles and the Raman spectra are promising results, opening up possibilities for on-chip trapping and Raman spectroscopy of biological particles such as

A novel dry-blending method to reduce the coefficient of thermal expansion of polymer templates for OTFT electrodes

• Xiangdong Ye,
• Bo Tian,
• Yuxuan Guo,
• Fan Fan and
• Anjiang Cai

Beilstein J. Nanotechnol. 2020, 11, 671–677, doi:10.3762/bjnano.11.53

• template, Kalsoom et al. [15] treated non-porous HPHT microdiamond powder with a size of 2–4 μm with sodium hydroxide and nitric acid followed by intensive washing with deionised water to reduce the tendency to agglomerate. Then, 30 wt % of the synthetic microparticles was added to the acrylate polymer to

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• microparticles (10–200 µm) fabricated via stop flow lithography have emerged as useful templates to form custom-shaped and flexible microcapsules of poly-ʟ-lysine (PLL) [36]. The shell was formed by diffusion of PLL into an oppositely charged hydrogel matrix, enabling an easy surface modification that can be

Nonclassical dynamic modeling of nano/microparticles during nanomanipulation processes

• Moharam Habibnejad Korayem,
• Ali Asghar Farid and
• Rouzbeh Nouhi Hefzabad

Beilstein J. Nanotechnol. 2020, 11, 147–166, doi:10.3762/bjnano.11.13

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• permeability of the PBMEC monolayer [19][20]. Liu et al. showed a size-dependent effect of SiO2 particles on the expression of occludin and ZO-1 and BBB permeability with particles in the nanometer range causing a decrease in TJ protein expression and an increase in permeability, whereas microparticles did not

Enhancement in thermoelectric properties due to Ag nanoparticles incorporated in Bi₂Te₃ matrix

• Srashti Gupta,
• Dinesh Chandra Agarwal,
• Bathula Sivaiah,
• Sankarakumar Amrithpandian,
• Kandasami Asokan,
• Ajay Dhar,
• Binaya Kumar Panigrahi,
• Devesh Kumar Avasthi and
• Vinay Gupta

Beilstein J. Nanotechnol. 2019, 10, 634–643, doi:10.3762/bjnano.10.63

• how different annealing temperatures lead to the different sizes and shapes of nanoparticles with different influence on thermoelectric properties. We have used different amounts of Ag microparticles (0, 2. 5, 10, 15 and 20 wt %) uniformly mixed with commercially purchased Bi2Te3, which was annealed

Study of silica-based intrinsically emitting nanoparticles produced by an excimer laser

• Imène Reghioua,
• Mattia Fanetti,
• Sylvain Girard,
• Diego Di Francesca,
• Simonpietro Agnello,
• Layla Martin-Samos,
• Marco Cannas,
• Matjaz Valant,
• Melanie Raine,
• Marc Gaillardin,
• Nicolas Richard,
• Philippe Paillet,
• Aziz Boukenter,
• Youcef Ouerdane and
• Antonino Alessi

Beilstein J. Nanotechnol. 2019, 10, 211–221, doi:10.3762/bjnano.10.19

• different sizes, from several tens up to hundreds of nanometers. Furthermore, some microparticles are also present. Similar results were obtained when surveying other parts of the same sample. In panel b a small group of nanoparticles of a few tens of nanometers is shown, which is a feature frequently

• be mainly located inside the nanoparticles rather than on their surface. Some microparticles were also detected in sample B. Similarly, although in the SEM and TEM images, the spherical particles appear more frequent than in sample A, irregular particles of different sizes were detected, too. The

• microparticles can be justified by the fact that in some cases, the sample featured some explosion. Regardless, the comparison between the pure and the Ge-doped samples highlight the advantage of having Ge atoms in the material thanks to their ability in forming oxygen-deficient centers such as the GLPCs [19][32

Colloidal chemistry with patchy silica nanoparticles

• Pierre-Etienne Rouet,
• Cyril Chomette,
• Laurent Adumeau,
• Etienne Duguet and
• Serge Ravaine

Beilstein J. Nanotechnol. 2018, 9, 2989–2998, doi:10.3762/bjnano.9.278

• chloride) [15]. Another way to get valence-endowed particles relies on shape recognition. Shape can indeed direct colloidal assembly as it was shown that linear supracolloidal polymers are obtained by self-assembly of cone-shaped particles in the presence of a depletant [16]. Similarly, microparticles with

The role of adatoms in chloride-activated colloidal silver nanoparticles for surface-enhanced Raman scattering enhancement

• Nicolae Leopold,
• Andrei Stefancu,
• Krisztian Herman,
• István Sz. Tódor,
• Stefania D. Iancu,
• Vlad Moisoiu and
• Loredana F. Leopold

Beilstein J. Nanotechnol. 2018, 9, 2236–2247, doi:10.3762/bjnano.9.208

• understanding some fundamental principles behind SERS. In this study, we describe a fast (<10 min) and simple protocol for obtaining highly SERS-active colloidal silver nanoparticles (AgNPs) with a mean diameter of 36 nm by photoconversion from AgCl precursor microparticles in the absence of any organic

• microparticles to AgNPs in the first 10 min of light exposure. Mixing the silver nitrate and sodium chloride in the reacting solution resulted in the generation of a flocculent precipitate of AgCl. The presence of AgCl particles in the solution was evidenced in the UV–vis spectra as an intense absorption band at

• exposure is shown in Figure S2B (using crystal violet as an analyte). The formation of AgNPs from AgCl precursor microparticles can be also followed in the scanning electron microscopy (SEM) micrographs depicted in Figure 3. Figure 3a shows 1–2 μm AgCl particles formed after mixing silver nitrate and

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98