Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy

• Shanka Walia and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2015, 6, 546–558, doi:10.3762/bjnano.6.57

• applications for diagnosis and therapy of disease sites. Through smart and careful chemical modifications of the nanoparticle surface, these can be converted to multifunctional tiny objects which in turn can be used as vehicle for delivering multimodal imaging agents and therapeutic material to specific target

• will cover a full description of MRI-active and fluorescent multifunctional silica micro/nanospheres including the design of the probe, different characterization methods and their application in imaging and treatment in cancer. Keywords: bimodal imaging; fluorescence imaging; magnetic nanoparticles

• (negative contrast, modified T2). Similarly the fluorescent CAs includes different lanthanide complexes, rare earth oxides, organic dyes, QDs, and ruthenium complexes. In this review article, we summarize recent literature reports on multifunctional nanocomposites for MRI and fluorescence imaging that are

Hollow plasmonic antennas for broadband SERS spectroscopy

• Gabriele C. Messina,
• Mario Malerba,
• Pierfrancesco Zilio,
• Ermanno Miele,
• Michele Dipalo,
• Lorenzo Ferrara and
• Francesco De Angelis

Beilstein J. Nanotechnol. 2015, 6, 492–498, doi:10.3762/bjnano.6.50

• large enhancement of the vibrational features both in the case of resonant excitation and out-of-resonance excitation. Such characteristics indicate that these structures are potential candidates for plasmonic enhancers in multifunctional opto-electronic biosensors. Keywords: biosensing; multiband

• further integration of the nanocylinders in devices requiring multifunctional plasmonic properties over a broad wavelength range for the deep investigation of the complete cell environment. (a) Illustrative scheme representing the structure of a single antenna and (b) SEM images at different

Biological responses to nanoscale particles

• Reinhard Zellner

Beilstein J. Nanotechnol. 2015, 6, 380–382, doi:10.3762/bjnano.6.37

• subcellular levels (as well as their consequences for cell integrity and function) constituted the priorities for this research. In addition to “simple” nanoparticles, some groups in the SPP1313 have also focused on the synthesis of multifunctional particles, in which parameters such as fluorescence, surface

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

Mechanical properties of MDCK II cells exposed to gold nanorods

• Anna Pietuch,
• Bastian Rouven Brückner,
• David Schneider,
• Marco Tarantola,
• Christina Rosman,
• Carsten Sönnichsen and
• Andreas Janshoff

Beilstein J. Nanotechnol. 2015, 6, 223–231, doi:10.3762/bjnano.6.21

• membrane rendering them prime candidates for multifunctional carriers [6][7][8]. Potential applications encompass selective drug delivery, photothermal therapy, reporters for biosensors and the use as contrast agents [5][9]. Targets can be addressed specifically by functionalization of the particle surface

Multifunctional layered magnetic composites

• Maria Siglreitmeier,
• Baohu Wu,
• Tina Kollmann,
• Martin Neubauer,
• Gergely Nagy,
• Dietmar Schwahn,
• Vitaliy Pipich,
• Damien Faivre,
• Dirk Zahn,
• Andreas Fery and
• Helmut Cölfen

Beilstein J. Nanotechnol. 2015, 6, 134–148, doi:10.3762/bjnano.6.13

• Potsdam, Germany 10.3762/bjnano.6.13 Abstract A fabrication method of a multifunctional hybrid material is achieved by using the insoluble organic nacre matrix of the Haliotis laevigata shell infiltrated with gelatin as a confined reaction environment. Inside this organic scaffold magnetite nanoparticles

• properties of two biominerals in one and the same material and, thus, to create a multifunctional hybrid material. We claim that this bioinspired material could find potential application in various fields. In general, it could be very interesting for the field of abrasive and fracture resistant materials

• Discussion Synthetic concept It is the aim to synthesize a material of larger dimensions by developing a multifunctional biomimetic composite structure, which combines properties of two biominerals in one and the same material, namely nacre and chiton teeth. To reach this goal we follow the key synthesis

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• multifunctional, BNNT-based nanocarrier was synthesized using an Fe catalyst to render them magnetic and coated with PEI whereby QDs were attached to the PEI-coated BNNTs [83]. The cellular uptake of the BNNTs was tracked by QDs which revealed that the cellular uptake of the BNNTs depends upon the distance from

Inorganic Janus particles for biomedical applications

• Isabel Schick,
• Steffen Lorenz,
• Dominik Gehrig,
• Stefan Tenzer,
• Wiebke Storck,
• Karl Fischer,
• Dennis Strand,
• Frédéric Laquai and
• Wolfgang Tremel

Beilstein J. Nanotechnol. 2014, 5, 2346–2362, doi:10.3762/bjnano.5.244

• , synthesis, and properties of multifunctional nanoparticles owing to their special structure–property relationship [1]. Due to their distinct surface properties, these nanomaterials can be modified by various ligands to introduce the desired surface characteristics ranging from solubility in selected

• complexity through asymmetry is a major challenge in synthetic nanochemistry (Figure 1). Hetero-nanoparticles facilitate an even more advanced approach toward the design of today’s highly desired multifunctional nanoparticles used in research at the interface between materials science, biotechnology, and

• precursors were mixed simultaneously. Janus particles as multimodal contrast agents Recent developments in the field of nanoparticles for biomedical applications have increased the interest in multifunctional nanoparticles for theranostics, a combination of therapy and diagnostics, which was realized with

Hybrid spin-crossover nanostructures

• Carlos M. Quintero,
• Gautier Félix,
• Iurii Suleimanov,
• José Sánchez Costa,
• Gábor Molnár,
• Lionel Salmon,
• William Nicolazzi and
• Azzedine Bousseksou

Beilstein J. Nanotechnol. 2014, 5, 2230–2239, doi:10.3762/bjnano.5.232

• to access the multifunctional potential of novel nanomaterials was the development of nanohybrid or nanocomposite structures that are able to combine different materials with different properties. Typically, in this approach, at least one of the components is organic while the other is inorganic in

• different shell materials. Although they observed a very interesting effect of the shell thickness on the SCO properties, their study did not aim for development of multifunctional materials. Titos-Padilla et al. [21] reported a core–shell nanocomposite with a SCO core synthetized from the coordination

• single layer NPs seem to behave differently from the double layer nanostructures. Namely, the single layer NPs exhibit a paramagnetic behavior while the double layer NPs exhibit ferromagnetism. Therefore, these new hybrid materials may be considered as multifunctional. The third type of core–shell or

Electrostatic interplay: The interaction triangle of polyamines, silicic acid, and phosphate studied through turbidity measurements, silicomolybdic acid test, and ²⁹Si NMR spectroscopy

• Anne Jantschke,
• Katrin Spinde and
• Eike Brunner

Beilstein J. Nanotechnol. 2014, 5, 2026–2035, doi:10.3762/bjnano.5.211

• Forschungsgemeinschaft (grants no. Br 1278/24-1 within the Research Unit FOR 2038 “Nanopatterned Organic Matrices in Biological Silica Mineralization” and Br 1278/ 25-2 within the SPP 1562 “Generation of Multifunctional Inorganic Materials by Molecular Bionics”).

Patterning a hydrogen-bonded molecular monolayer with a hand-controlled scanning probe microscope

• Matthew F. B. Green,
• Taner Esat,
• Christian Wagner,
• Philipp Leinen,
• Alexander Grötsch,
• F. Stefan Tautz and
• Ruslan Temirov

Beilstein J. Nanotechnol. 2014, 5, 1926–1932, doi:10.3762/bjnano.5.203

• atoms or small molecules adsorbed on surfaces with a highly symmetric structure, their success can be explained to a large extent by the fact that the high symmetry of the surface considerably simplifies the potential of the junction in multifunctional state space [5][8]. At the same time it is clear

Microstructural and plasmonic modifications in Ag–TiO₂ and Au–TiO₂ nanocomposites through ion beam irradiation

• Venkata Sai Kiran Chakravadhanula,
• Yogendra Kumar Mishra,
• Venkata Girish Kotnur,
• Devesh Kumar Avasthi,
• Thomas Strunskus,
• Vladimir Zaporotchenko,
• Dietmar Fink,
• Lorenz Kienle and
• Franz Faupel

Beilstein J. Nanotechnol. 2014, 5, 1419–1431, doi:10.3762/bjnano.5.154

• significant research interest due their multifunctional properties appropriate for various applications ranging from solar cells to targeted drug delivery [1][2][3][4]. The plasmonic properties of the nanocomposite films mainly depend upon the type of nanoparticles (Au or Ag), their morphology and the

• utilized to fabricate different multifunctional nanocomposites for different applications [7][8][9]. Generally, the main motivation behind the use of an insulating matrix is to maintain the necessary separation between metal nanoparticles (resulting from differences in surface energy of the individual

PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

• Paula M. Castillo,
• Mario de la Mata,
• Maria F. Casula,
• José A. Sánchez-Alcázar and
• Ana P. Zaderenko

Beilstein J. Nanotechnol. 2014, 5, 1312–1319, doi:10.3762/bjnano.5.144

• to be extended to other active molecules extracted from natural products. In addition, these materials offer the potential of being further implemented for combined imaging and therapeutics, as magnetic nanoparticles are known to be multifunctional tools for biomedicine. Keywords: camptothecin

Nanoporous composites prepared by a combination of SBA-15 with Mg–Al mixed oxides. Water vapor sorption properties

• Amaury Pérez-Verdejo,
• Alvaro Sampieri,
• Heriberto Pfeiffer,
• Mayra Ruiz-Reyes,
• Juana-Deisy Santamaría and
• Geolar Fetter

Beilstein J. Nanotechnol. 2014, 5, 1226–1234, doi:10.3762/bjnano.5.136

• might be utilized as as acid-base catalysts, adsorbents, sensors or storage nanomaterials. Keywords: calcined Mg–Al hydrotalcite; nanoporous composites; SBA-15; vapor sorption; Introduction Multifunctional nanomaterials are designed to satisfy specific ranged sets of performance requirements. The

• hydrophobic–hydrophilic character, among other physicochemical properties. The most studied multifunctional materials are the hybrids, which are good candidates for biomedical applications, e.g., biosensors, artificial bonds and bioadsorbents [4][5]. Instead, a few works report the design of purely inorganic

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• work, we developed a novel ND meditated drug delivery system to increase specificity of DOX by utilizing DGEA to target the α2β1 integrins overexpressed in metastatic prostate cancers. ND-DGEA conjugates and the ND-DGEA+DOX system were synthesized and evaluated for multifunctional applications (i.e

Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone

• Xiaohong Wang,
• Heinz C. Schröder and
• Werner E. G. Müller

Beilstein J. Nanotechnol. 2014, 5, 610–621, doi:10.3762/bjnano.5.72

Encapsulation of nanoparticles into single-crystal ZnO nanorods and microrods

• Jinzhang Liu,
• Marco Notarianni,
• Llew Rintoul and
• Nunzio Motta

Beilstein J. Nanotechnol. 2014, 5, 485–493, doi:10.3762/bjnano.5.56

• synthesis methods and applications. ZnO is a multifunctional material with semiconducting, photonic, and piezoelectric properties. Potential applications of ZnO 1D nanostructures include gas sensor [1], transistor [2], light-emitting device [3], optical waveguide [4], nanolaser [5], and piezoelectric power

Plasma-assisted synthesis and high-resolution characterization of anisotropic elemental and bimetallic core–shell magnetic nanoparticles

• M. Hennes,
• A. Lotnyk and
• S. G. Mayr

Beilstein J. Nanotechnol. 2014, 5, 466–475, doi:10.3762/bjnano.5.54

• any sputterable material, thus paving the way for synthesis of novel multifunctional NPs. Schematic drawing of the home-built UHV setup used in the present study. CM: capacitance manometers, CC: cold cathode, TMP: turbo molecular pump, CW: cooling water, v: valve, pv: gate valve, SG: sputter gun, n

Near-infrared dye loaded polymeric nanoparticles for cancer imaging and therapy and cellular response after laser-induced heating

• Tingjun Lei,
• Alicia Fernandez-Fernandez,
• Romila Manchanda,
• Yen-Chih Huang and
• Anthony J. McGoron

Beilstein J. Nanotechnol. 2014, 5, 313–322, doi:10.3762/bjnano.5.35

• developed IR820-PGMD NPs, which are promising as theranostic agents with multifunctional imaging and HT capabilities. These NPs, when tested in vitro and in vivo, are able to yield higher fluorescence intensity than free IR820 24 h after incubation or 24 h after i.v. injection of equivalent dye

Macromolecular shape and interactions in layer-by-layer assemblies within cylindrical nanopores

• Thomas D. Lazzara,
• K. H. Aaron Lau,
• Wolfgang Knoll,
• Andreas Janshoff and
• Claudia Steinem

Beilstein J. Nanotechnol. 2012, 3, 475–484, doi:10.3762/bjnano.3.54

• -assemblies can be similarly understood. Our results and experimental approach provide insight into tailoring the internal structure of multilayer LbL assemblies in nanopores towards generating multifunctional LbL films within nanoporous materials. Experimental Materials Lyophilized avidin was purchased from

Surface functionalization of aluminosilicate nanotubes with organic molecules

• Wei Ma,
• Weng On Yah,
• Hideyuki Otsuka and
• Atsushi Takahara

Beilstein J. Nanotechnol. 2012, 3, 82–100, doi:10.3762/bjnano.3.10

• water content increases and there is a risk of formation of multilayers due to the uncontrolled polymerization of the multifunctional organosilanes [17][18]. Phosphorus derivatives are much less sensitive to nucleophilic substitution than silicon derivatives are, because phosphorus has a higher