Microneedle-based ocular drug delivery systems – recent advances and challenges

• Piotr Gadziński,
• Anna Froelich,
• Monika Wojtyłko,
• Antoni Białek,
• Julia Krysztofiak and
• Tomasz Osmałek

Beilstein J. Nanotechnol. 2022, 13, 1167–1184, doi:10.3762/bjnano.13.98

• numerous inflammatory conditions to the posterior segment of the eye. A microneedle scleral patch (MSP) and a microneedle corneal patch (MCP) were obtained by micromolding with the use of PVP. The ex vivo experiments performed on porcine eye globe showed that, in comparison to MCP and TA nanosuspension

Antibacterial activity of a berberine nanoformulation

• Hue Thi Nguyen,
• Tuyet Nhung Pham,
• Anh-Tuan Le,
• Nguyen Thanh Thuy,
• Tran Quang Huy and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2022, 13, 641–652, doi:10.3762/bjnano.13.56

• ], particle size reduction [25], and encapsulation in nanoscale delivery systems [11]. Nanoscale BBR crystals can be formed using top-down technologies (ball mills, high-pressure homogenizers, microfluidic technology, and spray drying) or bottom-up technologies (evaporative precipitation of nanosuspension

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

• Sadaf Mushtaq,
• Khuram Shahzad,
• Tariq Saeed,
• Anwar Ul-Hamid,
• Bilal Haider Abbasi,
• Nafees Ahmad,
• Waqas Khalid,
• Muhammad Atif,
• Zulqurnain Ali and
• Rashda Abbasi

Beilstein J. Nanotechnol. 2021, 12, 1339–1364, doi:10.3762/bjnano.12.99

• hydrophilic groups. The hydrophobic side chains interact with the hydrophobic surfactant (oleic acid) present on the surface of NPs, thereby exposing the hydrophilic end to interact with the aqueous environment and contributing towards a colloidal nanosuspension [23]. The surfaces of the NPs were further

Use of nanosystems to improve the anticancer effects of curcumin

• Andrea M. Araya-Sibaja,
• Norma J. Salazar-López,
• Krissia Wilhelm Romero,
• José R. Vega-Baudrit,
• J. Abraham Domínguez-Avila,
• Carlos A. Velázquez Contreras,
• Ramón E. Robles-Zepeda,
• Mirtha Navarro-Hoyos and
• Gustavo A. González-Aguilar

Beilstein J. Nanotechnol. 2021, 12, 1047–1062, doi:10.3762/bjnano.12.78

• , cell, or organelle, improving solubility, dissolution rate, and pharmacokinetics [5]. In the case of CUR, the nanosystem size directly influences its biodistribution as demonstrated by Bi et al. [41], who reported differences in the pharmacokinetic profiles when they administered CUR nanosuspension of

• produced as a powder or as an aqueous suspension containing only the drug [46]. Some authors refer to nanocrystals as indistinguishable from nanosuspensions [47], which may be due to subtle differences between them (Figure 2). Strictly speaking, a nanosuspension is a colloidal dispersion of pure particles

• of a drug which is stabilized by the use of surfactants [48]. Therefore, a nanosuspension can be prepared by dispersing a nanocrystal or any other powdered material in an outer liquid medium using a stabilizing agent [45]. Furthermore, these nanosystems have shown increased adhesion to surfaces. The

Preservation of rutin nanosuspensions without the use of preservatives

• Pascal L. Stahr and
• Cornelia M. Keck

Beilstein J. Nanotechnol. 2019, 10, 1902–1913, doi:10.3762/bjnano.10.185

• -term stability. The freeze–thaw process for nanosuspensions is a simple concept and is suggested as alternative, when preserved nanosuspensions cannot be used. Keywords: nanocrystals; nanosuspension; no preservative; rutin; stability; Introduction Nanocrystals for pharmaceutical use were invented in

• need to be stored, which certainly requires a sufficient stability of the nanosuspension. For this, besides chemical and physical stability, also the microbial stability needs to be considered. One method to avoid microbial contamination of aqueous formulations during storage is the use of

• of all aliquots during storage. The data are in good agreement with a recent study by Müller et al. in which the authors could prove chemical stability of a rutin nanosuspension for more than nine years [25]. Microbial quality The growth of bacteria and fungi was determined for all formulations after

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

• Maria J. Ramalho,
• Joana A. Loureiro,
• Bárbara Gomes,
• Manuela F. Frasco,
• Manuel A. N. Coelho and
• M. Carmo Pereira

Beilstein J. Nanotechnol. 2015, 6, 1306–1318, doi:10.3762/bjnano.6.135

• electrostatic forces due to the PLGA carboxylate groups at the NP surface, and the surfactant behavior that also plays a crucial role in maintaining nanosuspension stabilization. During particle formation, the Pluronic®F127 is adsorbed onto the NP surface, providing steric and thermodynamic stabilization

Near-field effects and energy transfer in hybrid metal-oxide nanostructures

• Ulrich Herr,
• Balati Kuerbanjiang,
• Cahit Benel,
• Giorgos Papageorgiou,
• Manuel Goncalves,
• Johannes Boneberg,
• Paul Leiderer,
• Paul Ziemann,
• Peter Marek and
• Horst Hahn

Beilstein J. Nanotechnol. 2013, 4, 306–317, doi:10.3762/bjnano.4.34

• with surfactants. In this part of the study, we used a nanosuspension based on a commercial fluorescent organic pigment (VTLUNP by LuminoChem), which exhibits excitation and emission spectra very similar to the ones of the TiO2:Eu. The luminescent center in this pigment is Eu. The emission spectrum for

• nanosuspension exhibits a narrow particle size distribution centered around 23 nm, as confirmed by dynamic-light-scattering measurements. The nanosuspensions were spin coated at 2000 rpm for 10 s onto Ag nanoantennas. AFM scans of the coated samples show smooth surfaces with roughness values of a few nanometers

• fluorescent nanosuspension with narrow size distribution and similar optical properties. Quenching of the Eu fluorescence at the Ag nanoantennas has been observed by confocal microscopy of the fluorescent emission. The quenching can be reduced by deposition of a 10 nm thick SiOx spacer layer. In the systems