Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• and thus the enhanced toxicity in the tumour cells. The sustained release of 5-FU from the CaP@5-FU NPs, as described in the pH-triggered release study, was found to correlate with the findings of the MTT assay. The HCT-15 cell lines showed a saturation limit of the free drug after 10 µg/mL, whereas

pH-Triggered release from surface-modified poly(lactic-co-glycolic acid) nanoparticles

• Manuel Häuser,
• Klaus Langer and
• Monika Schönhoff

Beilstein J. Nanotechnol. 2015, 6, 2504–2512, doi:10.3762/bjnano.6.260

• the nanoparticles with high concentrations of sodium chloride shows no further release and thus demonstrates the pH-driven release to be quantitative. Keywords: layer-by-layer self-assembly; pH-triggered release; PLGA nanoparticles; polyelectrolyte multilayers; weak polyelectrolyte; Introduction The

• modified by successive adsorption of four polyelectrolyte layers in total, containing in particular the weak polyanion PAA. We demonstrate that an appropriate pH stimulus induces a controlled release of the polycationic species poly(diallyldimethylammonium chloride) (PDADMAC). The successful pH-triggered

• release of PDADMAC is concluded from 1H NMR spectroscopy. Although 1H NMR spectroscopy lacks sensitivity, it has significant advantages with respect to selectivity and robustness compared to current state of the art analytical methods, such as chromatography and titration strategies [28], which are