Fabrication of metal complex phthalocyanine and porphyrin nanoparticle aqueous colloids by pulsed laser fragmentation in liquid and their potential application to a photosensitizer for photodynamic therapy

• Taisei Himeda,
• Risako Kunitomi,
• Ryosuke Nabeya,
• Tamotsu Zako and
• Tsuyoshi Asahi

Beilstein J. Nanotechnol. 2025, 16, 1088–1096, doi:10.3762/bjnano.16.80

• the activity of the target substance in general. An alternative and promising method for dispersing hydrophobic organic compounds as colloids is pulsed laser fragmentation in liquids (PLFL) [9][10]. This relatively new fabrication method has advantages because a microcrystalline sample powder

• fragmentation in liquids; reactive oxygen species generation; Introduction Porphyrins and phthalocyanines (Pcs), exhibiting intense absorption in the visible to near-infrared (NIR) regions, are well studied as photosensitizers in photodynamic therapy (PDT) [1]. Especially, Pcs absorb strongly light in the

• generation of reactive oxygen species by AlClPc, ZnPc, and PtOEP nanoparticles and the photocytotoxicity for PC12 and HeLa cells, and demonstrated that the nanoparticles can be used as photosensitizers for photodynamic therapy. Keywords: aqueous colloid; photosensitizer; phthalocyanine; pulsed laser

Efficiency of single-pulse laser fragmentation of organic nutraceutical dispersions in a circular jet flow-through reactor

• Tina Friedenauer,
• Maximilian Spellauge,
• Alexander Sommereyns,
• Verena Labenski,
• Tuba Esatbeyoglu,
• Christoph Rehbock,
• Heinz P. Huber and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 711–727, doi:10.3762/bjnano.16.55

• and dispersed three times for 5 s with an ultrasonic sonotrode (Hielscher Ultrasonics GmbH). Pulsed laser fragmentation in liquids For MP-LFL, an Edgewave PX400-3-GH laser (EdgeWave GmbH) with a wavelength of 532 nm, a pulse duration of 10 ps, and an average power of 10 W was used. In the established

Current state of laser synthesis of metal and alloy nanoparticles as ligand-free reference materials for nano-toxicological assays

• Christoph Rehbock,
• Jurij Jakobi,
• Lisa Gamrad,
• Selina van der Meer,
• Daniela Tiedemann,
• Ulrike Taylor,
• Wilfried Kues,
• Detlef Rath and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2014, 5, 1523–1541, doi:10.3762/bjnano.5.165

• pulsed laser fragmentation in liquids (PLFL), in situ size quenching by electrolytes, delayed conjugation in liquid flow and pulsed laser melting in liquids (PLML). For gold as an exemplary inert noble metal, these methods allow for the tuning of the particle diameters in the range 4–400 nm. However